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Copper tripeptide

CAS No.: 89030-95-5

Chemical Name:: Copper tripeptide

Synonyms: Copper tripeptide;GHK Copper;DEXM74;Ghk-Cu;DEX M 74;DEX M-74;DEX-M-74;GHK.CU.HAC;GHK-Cu (1:1);Ghk-Cu/AHK-CU

CBNumber:: CB52651405

Molecular Formula:: C14H21CuN6O4

Molecular Weight:: 400.91

MOL File:: 89030-95-5.mol

Modify Date:: 2024/7/25 20:04:51

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Copper tripeptide Properties

storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	Soluble in DMSO
form	Solid
color	Light blue to blue
Sequence	(Cu2+ )H-Glu-His-Lys-OH
InChIKey	DDNUEECOCUBKBT-MIIMWFGWNA-L
SMILES	C([C@@H]1CC2=CNC=N2[Cu+2]2NCC(=O)[N-]12)(=O)N[C@H](C(=O)[O-])CCCCN \|&1:1,16,r\|

Copper tripeptide Chemical Properties,Uses,Production

Description

Copper tripeptide, also known as [N2-(N-Glycyl-L-histidyl)-L-lysinato(2-)]copper or GHK-Cu, is a naturally occurring tripeptide. It was first isolated from human plasma but can be found in saliva and urine. During wound healing, it may be freed from existing extracellular proteins via proteolysis. Studies have shown that GHK-Cu has a maximal biological effect at 10^-9 mol/L and Its concentration in the body decreases with age[1].

Uses

Copper tripeptide (GHK-Cu) can be used as a skin antiaging agent. It could lead to the extracellular matrix accumulation increases in the rat wound model. Copper Peptide preparations were able to promote wound healing rates in diabetic ulcers and patients undergoing Mohs surgery. It could induce angiogenesis in rabbit models at 10?12 mol/L by acting as a chemoattractant for capillary cells. It may also improve the autocrine growth factor milieu in keloid fibroblasts[1-2]. It can also be doped into It can also be doped into binary binary PBDB-T: ITIC to tune the crystallinity and phase separation of the active layer, improving the performance of polymer solar cells[3].

Mechanism of action

At this concentration (10^-⁹ mol/L), GHK-Cu has been shown to increase messenger RNA production for collagen, elastin, proteoglycans, and glycosaminoglycans in fibroblasts. It has been demonstrated that GHK-Cu stimulates cultured normal fibroblasts to synthesize collagen and induces a dose-dependent increase in the synthesis of glycosaminoglycans. It could stimulate the regeneration of skin, nervous tissue, bones, lungs, and liver, protect the liver from oxidative damage, restore the activity of irradiated fibroblasts, reduce inflammation, and increase levels of antioxidant enzymes[1].

Side effects

Copper tripeptide (GHK-Cu) is considered to be very safe but there are always a few side effects related to any substance that is taken for health. When using creams, you might have mild skin irritation if you are one of the very few people with sensitivity. When the substance has been injected, people have reported that they experience cramping and burning at the injection site.
Other reported side effects are: Headache; Dizziness; Fatigue; Nausea; Elevated blood pressure; Lowered blood pressure; Increase in appetite; Redness and pain at the injection site; Cramping at the injection site.

References

[1] Jeffrey D, et al. Effects of Copper Tripeptide on the Growth and Expression of Growth Factors by Normal and Irradiated Fibroblasts. Archives of Facial Plastic Surgery, 2005; 7.
[2] Huang J, et al. Efficient Ternary Polymer Solar Cells with Tunable Crystallinity and Phase Separation of Active Layers via Incorporating GHK-Cu. ACS Applied Materials Interfaces, 2021; 13: 46927–46937.
[3] Pickart L, et al.Modulation of Gene Expression in Human Breast Cancer MCF7 and Prostate Cancer PC3 Cells by the Human Copper-Binding Peptide GHK-Cu, 2021; 5.

Copper tripeptide Preparation Products And Raw materials

Raw materials

Preparation Products

Copper tripeptide Suppliers

Global( 186)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
CONTIDE BIOTECH CO.,LTD	+852-53358525	China	568	58	Inquiry
Hebei Xunou new energy Technology Co., LTD	+undefined17531957005	China	36	58	Inquiry
BOC Sciences	16314854226; +16314854226	United States	19743	58	Inquiry
zhuzhou dingcheng meihei comestic co.,ltd	+8618873369619	China	260	58	Inquiry
Hubei Yuanao Technology CO Ltd	+86-15377628618 +86-15377628618	China	6	58	Inquiry
Sichuan HongRi Pharma-Tech Co.,Ltd	+86-028-64841719 +8617390183901	China	1106	58	Inquiry
hebei hongtan Biotechnology Co., Ltd	+86-86-1913198-3935 +8617331935328	China	973	58	Inquiry
Strong peptide cross-border e-commerce Co. LTD	+undefined13930052870	China	84	58	Inquiry
Dorne Chemical Technology co. LTD	+86-86-13583358881 +8618560316533	China	3146	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
CONTIDE BIOTECH CO.,LTD	58
Hebei Xunou new energy Technology Co., LTD	58
BOC Sciences	58
zhuzhou dingcheng meihei comestic co.,ltd	58
Hubei Yuanao Technology CO Ltd	58
Sichuan HongRi Pharma-Tech Co.,Ltd	58
hebei hongtan Biotechnology Co., Ltd	58
Strong peptide cross-border e-commerce Co. LTD	58
Dorne Chemical Technology co. LTD	58

The benefits of Copper tripeptide
The human copper-binding peptide GHK-Cu (glycyl-l-histidyl-l-lysine; Copper tripeptide) is a small, naturally occurring tri-pe....
Apr 22，2024

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