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ChemicalBook > Product Catalog >Biochemical Engineering >Amino Acids and Derivatives >Nonapeptide-1

Nonapeptide-1

Nonapeptide-1 Structure
CAS No.
158563-45-2
Chemical Name:
Nonapeptide-1
Synonyms
melanostatine;Melanostatine-5;Melitan;Neptide-1;ArkTide N91;Jiupeptide-1;NONAPEPTIDE-1;Metanostatine-5;Melitane / Nonapeptide-1;hexapeptide-2/Dermostatyl
CBNumber:
CB13052001
Molecular Formula:
C61H87N15O9S
Molecular Weight:
1206.5
MOL File:
158563-45-2.mol
Modify Date:
2024/9/2 8:45:58
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Nonapeptide-1 Properties

Density 1.38±0.1 g/cm3(Predicted)
solubility soluble in water(≥0.1g/ml)
form Solid
pka 13.32±0.46(Predicted)
color white or off-white powder
InChIKey KNFLNGRLKALWRF-LDXSYGEZSA-N

Nonapeptide-1 Chemical Properties,Uses,Production

Description

Nonapeptide-1 is a skin lightening peptide, derived from the melanocyte stimulating hormone (MSH). It prevents the activity of tyrosine in the melanocytes, melanin synthesis inhibition and helps to even out your skin tone by lessening hyper-pigmentation. This process reduces the formation of unwanted pigmentation, allowing for the control over skin tone and brown spots.

Uses

A skin whitening nonapeptide. It can be applied to various kinds of whitening or spot corrective products.

Definition

Nonapeptide-1 is one skin whitening nonapeptide. It can be applied to various kinds of whitening or spot corrective products.

Application

skin radiance, skin Lightening-whitening, anti-dark spot

Biological Functions

1. Inhibit melanin synthesis by interfering with the action of tyrosinase in melanocytes. Reduce hyperpigmentation and lighten darker areas that have been damaged by the sun and certain diseases.2. Interfer with melanocyte stimulating hormone (MSH). MSH increases during pregnancy, as a result of certain medical conditions (e.g. diabetes, Addison’s disease), and as a result of excessive sun exposure.3. Nonapeptide-1, at a concentration of 200 ug/mL, is capable of fully inhibiting the synthesis of melanin in fungi.4. At 100 micromolar concentration, nonapeptide-1 can inhibit 25-35% of tyrosinase activity in animal models and can reduce the melanin content of melanocytes by 27-43%

Biotechnological Applications

Nonapeptide-1 acetate salt, a peptide hormone, is a potent α-Melanocyte-stimulating hormone (α-MSH) antagonist, with an IC50 of 11 nM. Reduces synthesis of melanin and helps decrease skin pigmentation to a substantial degree[1].

Side effects

May cause drowsiness, dizziness, hypotension, or a headache as side-effects when using Nonapeptide-1 Topical medicine. Patients not drink alcohol with medicines as alcohol intensifies drowsiness side-effects.

storage

Common storage 2-8℃, long time storage -20℃.

Nonapeptide-1 Preparation Products And Raw materials

Raw materials

Preparation Products

Nonapeptide-1 Suppliers

Global( 275)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Shanghai Getian Industrial Co., LTD +86-15373193816 +86-15373193816 China 269 58 Inquiry
Cellmano Biotech Limited 0551-65326643 18156095617 China 999 58 Inquiry
Xinxiang Hongqi District Houyuan Trading Co.,Ltd +86-0373-3695376 +86-13937349994 China 300 58 Inquiry
Hantai Biomedical Group Co. LTD +8618819265912 China 37 58 Inquiry
GIHI CHEMICALS CO.,LIMITED +8618058761490 China 50000 58 Inquiry
Hebei Mojin Biotechnology Co., Ltd +86 13288715578 +8613288715578 China 12447 58 Inquiry
Shanghai UCHEM Inc. +862156762820 +86-13564624040 China 7121 58 Inquiry
Shanghai Yunao International Trade Co., Ltd +8617621705551 China 265 58 Inquiry
Hebei Fengjia New Material Co., Ltd +86-0311-87836622 +86-17333973358 China 8057 58 Inquiry
Supplier Advantage
A.J Chemicals 58
Shanghai Getian Industrial Co., LTD 58
Cellmano Biotech Limited 58
Xinxiang Hongqi District Houyuan Trading Co.,Ltd 58
Hantai Biomedical Group Co. LTD 58
GIHI CHEMICALS CO.,LIMITED 58
Hebei Mojin Biotechnology Co., Ltd 58
Shanghai UCHEM Inc. 58
Shanghai Yunao International Trade Co., Ltd 58
Hebei Fengjia New Material Co., Ltd 58

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L-Methionyl-L-prolyl-D-phenylalanyl-L-arginyl-D-tryptophyl-L-phenylalanyl-L-lysyl-L-prolyl-L-valinamide Melanostatine-5(nonpeptide-1) Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2 Melitane / Nonapeptide-1 Melanostatine-5, Nonapeptide-1 NONAPEPTIDE-1 Nonapeptide-1, Melanostatine-5, Melanostatine Melitan Nonapeptide-1/Melitane/Melanostatine Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val- L-Valinamide, L-methionyl-L-prolyl-D-phenylalanyl-L-arginyl-D-tryptophyl-L-phenylalanyl-L-lysyl-L-prolyl- Cosmetics peptide Nonapeptide-1 powder Nonapeptide-1(Melanostatine-5) Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2 USP/EP/BP hexapeptide-2/Dermostatyl superior quality Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2 CAS 158563-45-2 CAS 158563-45-2 Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2 Melanostatine-5 melanostatine Metanostatine-5 4-Hydroxypyridine 626-64-2 (Met?,Pro?,D-Phe?,D-Trp?,Phe1?)-α-MSH (5-13) (Met?,Pro?,D-Phe?,D-Trp?,Phe??)-α-MSH (5-13) Jiupeptide-1 Neptide-1 ArkTide N91 158563-45-2 951-78-9 C61H87N15O9S 158563-45-2