(S)-1-Boc-3-hydroxymethyl-piperazine
- CAS No.
- 314741-40-7
- Chemical Name:
- (S)-1-Boc-3-hydroxymethyl-piperazine
- Synonyms
- tert-butyl (S)-3-(hydroxymethyl)piperazine-1-carboxylate;H57160;TL8002412;NSILYQWHARROMG-QMMMGPOBSA-N;(S)-4-N-Boc-2-hydroxyMeth...;(3S)-3-(Hydroxymethyl)piperazine;(S)-1-Boc-3-(hyroxyMethyl)piperazine;(S)-1-Boc-3-hydroxymethyl-piperazine;(S)-4-Boc-2-(Hydroxymethyl)piperazine;(3S)-1-Boc-3-(hydroxyMethyl)-piperazine
- CBNumber:
- CB0947688
- Molecular Formula:
- C10H20N2O3
- Molecular Weight:
- 216.28
- MOL File:
- 314741-40-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/10/16 10:47:52
| Boiling point | 322.9±22.0 °C(Predicted) |
|---|---|
| Density | 1.085±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| pka | 14.97±0.10(Predicted) |
| CAS DataBase Reference | 314741-40-7 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS02 |
|---|---|
| Signal word | Danger |
| Hazard statements | H320-H225 |
| Precautionary statements | P501-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P337+P313-P305+P351+P338-P303+P361+P353-P403+P235 |
| HS Code | 2933599590 |
(S)-1-Boc-3-hydroxymethyl-piperazine Chemical Properties,Uses,Production
Definition
(S)-1-Boc-3-hydroxymethyl-piperazine is also known as (S)-4-N-Boc-2-(hydroxymethyl)piperazine or (S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate.
Uses
(S)-4-N-Boc-2-(hydroxymethyl)piperazine is a useful research chemical.
Synthesis
To synthesize (S)-1-Boc-3-hydroxymethyl-piperazine, a stirred suspension of (S)-piperazine-l,3-dicarboxylic acid l-tert-buty ester (5.00 g, 21.7 mmol) in THF (40 mL) was prepared. Slowly, 1.0 M borane-THF complex solution (32.6 mL, 32.6 mmol) was added to the suspension. The reaction mixture was heated to 90 ℃ and stirred under reflux for 2 h. Before further proceeding, the mixture was removed from heat and an additional 1.5 equivalents of 1.0 M borane-THF complex solution (32.6 mL, 32.6 mmol) was added. The reaction was then reheated and stirred under reflux for 2 h. Subsequently, the reaction mixture was cooled to 0 ℃ and quenched by slowly adding methanol. The resulting mixture was concentrated under reduced pressure, yielding a white solid. This solid was dissolved in THF (30 mL) and cooled to 0 ℃. Slowly, a 2.0 M solution of lithium aluminum hydride (LiAlH4) in THF (27 mL, 54.0 mmol) was added. The reaction was heated to 90 ℃ and stirred under reflux for 2 h. Another portion of 2.0 M LiAlH4 was added, and the reaction mixture was stirred under reflux for 4 hours, followed by overnight stirring at RT. The reaction mixture was then cooled to 0 ℃ and quenched by slowly adding 1.0 M aqueous sodium hydroxide (NaOH) solution until the exothermic reaction subsided. The product (S)-1-Boc-3-hydroxymethyl-piperazine was obtained after purification.
(S)-1-Boc-3-hydroxymethyl-piperazine Preparation Products And Raw materials
Raw materials
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| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Shanghai Boc Chemical Co., Ltd. | 021-34975602; +8618721111801 | China | 138 | 58 | Inquiry |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; +8619817745290 | China | 5660 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29898 | 58 | Inquiry |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | China | 7513 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | CHINA | 21149 | 58 | Inquiry |
| Masteam Bio-tech Co., Ltd. | +86-15200345168 +86-15200345168 | CHINA | 153 | 58 | Inquiry |
| SIMAGCHEM CORP | +86-13806087780 | China | 17367 | 58 | Inquiry |
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