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ChemicalBook > Product Catalog >Pharmaceutical intermediates >(R)-1-BOC-3-(Hydroxymethyl)piperazine

(R)-1-BOC-3-(Hydroxymethyl)piperazine

(R)-1-BOC-3-(Hydroxymethyl)piperazine Structure
CAS No.
278788-66-2
Chemical Name:
(R)-1-BOC-3-(Hydroxymethyl)piperazine
Synonyms
tert-butyl (R)-3-(hydroxymethyl)piperazine-1-carboxylate;(R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate;tert-butyl (3R)-3-(hydroxymethyl)piperazine-1-carboxylate;tert-Butyl (3R)-3-(hydroxymethyl)-1-piperazinecarboxylate;H57159;(3R)-3-(hydroxymethyL;PIPERAZINE-1-CARBOXYLIC;(R)-4-N-Boc-2-hydroxyMeth...;(3R)-3-(Hydroxymethyl)piperazine;(R)-1-Boc-3-(hyroxyMethyl)piperazine
CBNumber:
CB9715509
Molecular Formula:
C10H20N2O3
Molecular Weight:
216.28
MOL File:
278788-66-2.mol
MSDS File:
SDS
Modify Date:
2024/7/12 15:32:57
Request For Quotation

(R)-1-BOC-3-(Hydroxymethyl)piperazine Properties

Melting point 68-70°C
Boiling point 322.9±22.0 °C(Predicted)
Density 1.085±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pka 14.97±0.10(Predicted)
color White to Off-White
InChI InChI=1S/C10H20N2O3/c1-10(2,3)15-9(14)12-5-4-11-8(6-12)7-13/h8,11,13H,4-7H2,1-3H3/t8-/m1/s1
InChIKey NSILYQWHARROMG-MRVPVSSYSA-N
SMILES N1(C(OC(C)(C)C)=O)CCN[C@@H](CO)C1
CAS DataBase Reference 278788-66-2(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301+H311+H331-H315-H319
Precautionary statements  P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P361+P364-P332+P313-P301+P310+P330-P302+P352+P312-P304+P340+P311-P403+P233-P405
Hazard Codes  Xi
Risk Statements  41-52
Safety Statements  26-39
HS Code  2933599590

(R)-1-BOC-3-(Hydroxymethyl)piperazine price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SYX00408 (R)-1-BOC-3-(Hydroxymethyl)piperazine 278788-66-2 1G ₹39998.38 2022-06-14 Buy
Product number Packaging Price Buy
SYX00408 1G ₹39998.38 Buy

(R)-1-BOC-3-(Hydroxymethyl)piperazine Chemical Properties,Uses,Production

Synthesis

1,4-bis-Boc-2-hydroxymethylpiperazine (13.9 kg) and 95% ethanol (30 kg) were added to the reactor, followed by the addition of an aqueous solution (water 21 kg) of configured sodium hydroxide (3.5 kg). The reaction mixture was then heated to reflux. Once the reaction was completed, ethanol was concentrated under reduced pressure. Subsequently, 30 kg of dichloromethane was added and the mixture was separated into liquid and aqueous phases. The aqueous phase was extracted three times with 3 × 20 kg of dichloromethane, and the organic phases were combined. The resulting solution was washed once with 40 kg of a 15% aqueous sodium chloride solution and dried with anhydrous sodium sulfate. Further purification was carried out to obtain (R)-1-BOC-3-(Hydroxymethyl)piperazine.
(R)-1-BOC-3-(Hydroxymethyl)piperazine

(R)-1-BOC-3-(Hydroxymethyl)piperazine Preparation Products And Raw materials

Raw materials

3H-Oxazolo[3,4-a]pyrazine-7(1H)-carboxylic acid, tetrahydro-1,3-dioxo-, 1,1-dimethylethyl ester, (8aR)- (R)-1,4-(DI-BOC)-2-(HYDROXYMETHYL)PIPERAZINE

Preparation Products

(R)-1-BOC-3-(Hydroxymethyl)piperazine Suppliers

Global( 243)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Ina pharmaceuticals Pvt Ltd +91 9515053169 Hyderabad, India 19 58 Inquiry
JIVICHEM SYNTHESIS PVT LTD +91-7028392790 +91-7028392790 Maharashtra, India 337 58 Inquiry
VGS SYNTHESIS PRIVATE LIMITED +91-9866975588 +91-9866975588 Hyderabad, India 1818 58 Inquiry
Stereokem Pvt Ltd +91-4029706929 +91-9394224843 Telangana, India 350 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Stereokem, Inc. 500039 New Delhi, India 293 58 Inquiry
Shanghai Boc Chemical Co., Ltd. 021-34975602; +8618721111801 China 138 58 Inquiry
Zibo Hangyu Biotechnology Development Co., Ltd +86-0533-2185556 +8617865335152 China 10991 58 Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
Hangzhou FandaChem Co.,Ltd. 008657128800458; +8615858145714 China 9240 55 Inquiry
Supplier Advantage
Ina pharmaceuticals Pvt Ltd 58
JIVICHEM SYNTHESIS PVT LTD 58
VGS SYNTHESIS PRIVATE LIMITED 58
Stereokem Pvt Ltd 58
A.J Chemicals 58
Stereokem, Inc. 58
Shanghai Boc Chemical Co., Ltd. 58
Zibo Hangyu Biotechnology Development Co., Ltd 58
Capot Chemical Co.,Ltd. 60
Hangzhou FandaChem Co.,Ltd. 55

(R)-1-BOC-3-(Hydroxymethyl)piperazine Spectrum

(R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(278788-66-2)1HNMR(R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(278788-66-2)FT-IR

278788-66-2((R)-1-BOC-3-(Hydroxymethyl)piperazine)Related Search:

N-BOC-(3S,4S)-3,4-PYRROLIDINEDIOL (S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester (R)-N-Boc-piperazine-2-carboxylic acid methyl ester (S)-1-Boc-3-hydroxymethyl-piperazine exo-3-Boc-3-azabicyclo[3.1.0]hexane-6-methanol
3-N-Boc-Cis-Tetrahydrofuran-3,4-Diamine tert-butyl (3S)-3-(hydroxymethyl)-2-azabicyclo[3.1.0]hexane-2-carboxylate (6R,7S)-2-BOC-2-AZA-BICYCLO[2.2.1]HEPT-5-EN-3-ONE (2S,4R)-4-hydroxy-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester rel-(3r,4r)-3-(boc-amino)-5-fluoropiperidine
tert-butyl ((3R,4R)-4-hydroxytetrahydro-2H-pyran-3-yl)carbamate tert-butyl (3R,4S)-3-amino-4-methylpyrrolidine-1-carboxylate tert-butyl (3R)-3-aMino-4-(hydroxyMethyl)pyrrolidine-1-carboxyla (R)-tert-butyl 4-(1-aminoethyl)piperidine-1-carboxylate 1-Pyrrolidinecarboxylicacid,3-(methylamino)-,1,1-dimethylethylester,(R)-(9CI)
(R)-N-Boc-3-(aminomethyl)pyrrolidine (R)-1-Boc-3-(Cyanomethyl)Piperidine tert-butyl (2R,3S)-2-(3-aminopropyl)-3-((tert-butyldimethylsilyl)oxy)piperidine-1-carboxylate
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(R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (R)-4-N-BOC-2-HYDROXYMETHYL-PIPERAZINE (R)-1-Boc-3-hydroxymethyl-piperazine H57159 (R)-4-Boc-2-hydroxymethyl-piperazine 1-Piperazinecarboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester, (3R)- (R)-1-Boc-3-(Hydroxymethyl)piperazine ,98% (R)-4-N-Boc-2-hydroxyMeth... (R)-1-Boc-3-(hyroxyMethyl)piperazine (3R)-3-(Hydroxymethyl)piperazine, N1-BOC protected tert-Butyl (3R)-3-(hydroxymethyl)piperazine-1-carboxylate, (3R)-1-(tert-Butoxycarbonyl)-3-(hydroxymethyl)piperazine (3R)-1-Boc-3-(hydroxyMethyl)-piperazine (3R)-3-(Hydroxymethyl)piperazine, N1-BOC protected 98% (3R)-3-(hydroxymethyL (3R)-3-(Hydroxymethyl)piperazine ert-butyl(3R)-3-(hydroxymethyl)piperazine-1-carboxylate (R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate tert-butyl (3R)-3-(hydroxymethyl)piperazine-1-carboxylate tert-butyl (R)-3-(hydroxymethyl)piperazine-1-carboxylate tert-Butyl (3R)-3-(hydroxymethyl)-1-piperazinecarboxylate PIPERAZINE-1-CARBOXYLIC (3R)-3-(hydroxymethyl)-1-Piperazinecarboxylic acid tert-butyl ester 278788-66-2 pharmacetical Piperaizine 1