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ChemicalBook > Product Catalog >Chemical Reagents >Organic reagents >Silane >1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE

1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE

1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE Structure
CAS No.
69304-37-6
Chemical Name:
1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE
Synonyms
TIPSCL;1,1,3,3-TETRAISOPROPYL-1,3-DICHLORODISILOXANE;TIPDSICL2;1,3-DICHLOROTETRAISOPROPYLDISILOXANE;DK365;DK870;JACS-69304-37-6;2,6-DiMethyl-3,5-dichloro;1,1,3,3-TETRAISOPROPYL-1,3-DICH;Bis(chlorodiisopropylsilyl) ether
CBNumber:
CB1100268
Molecular Formula:
C12H28Cl2OSi2
Molecular Weight:
315.43
MOL File:
69304-37-6.mol
MSDS File:
SDS
Modify Date:
2024/3/25 11:48:53
Request For Quotation

1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE Properties

Boiling point 70 °C0.5 mm Hg(lit.)
Density 0.986 g/mL at 25 °C(lit.)
refractive index n20/D 1.454(lit.)
Flash point >230 °F
storage temp. Inert atmosphere,2-8°C
solubility Miscible with dimethylformamide, hexane, ethyl acetate, chloroform and dichloromethane.
form Oil
color Colourless
Specific Gravity 0.986
Hydrolytic Sensitivity 8: reacts rapidly with moisture, water, protic solvents
Sensitive Moisture Sensitive
BRN 1934216
InChI InChI=1S/C12H28Cl2OSi2/c1-9(2)16(13,10(3)4)15-17(14,11(5)6)12(7)8/h9-12H,1-8H3
InChIKey DDYAZDRFUVZBMM-UHFFFAOYSA-N
SMILES [Si](Cl)(C(C)C)(C(C)C)O[Si](Cl)(C(C)C)C(C)C
CAS DataBase Reference 69304-37-6(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS05
Signal word  Danger
Hazard statements  H290-H314
Precautionary statements  P280-P303+P361+P353-P305+P351+P338+P310
Hazard Codes  C
Risk Statements  34
Safety Statements  26-27-28-36/37/39-45
RIDADR  UN 3265 8/PG 2
WGK Germany  3
F  10-21
Hazard Note  Corrosive
TSCA  No
HazardClass  8
PackingGroup  II
HS Code  29319090
NFPA 704
1
3 0

1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 337005 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane 97% 69304-37-6 1G ₹2987.7 2022-06-14 Buy
Sigma-Aldrich(India) 337005 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane 97% 69304-37-6 5G ₹10835.83 2022-06-14 Buy
TCI Chemicals (India) D1608 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane [Hydroxyl Protecting Agent] min. 97.0 % 69304-37-6 5G ₹8700 2022-05-26 Buy
TCI Chemicals (India) D1608 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane [Hydroxyl Protecting Agent] min. 97.0 % 69304-37-6 25G ₹15000 2022-05-26 Buy
Product number Packaging Price Buy
337005 1G ₹2987.7 Buy
337005 5G ₹10835.83 Buy
D1608 5G ₹8700 Buy
D1608 25G ₹15000 Buy

1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE Chemical Properties,Uses,Production

Chemical Properties

Colorless liquid

Physical properties

bp 70°C/0.5 mmHg; d 0.986 g cm?3.

Uses

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane can be used as simultaneous protection of the 3'- and 5'-hydroxyl functions of furanose nucleosides;protecting group for carbohydrates;3,4 protecting group reagent for open-chain polyhydroxy compounds; preparation of cyclic bridged peptides.
The reagent design was based upon the fact that triisopropylsilyl chloride reacts 1000 times faster with primary alcohols than secondary alcohols. Thus in the case of 3',5'-dihydroxy nucleosides the reagent initially silylates at the 5'-position. This is then followed by intramolecular reaction with the secondary alcohol at the 3'-position to give the doubly protected derivative (eq 1).intramolecular reaction

Uses

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane is used in the analysis of Watson-Crick and Hoogstein base pairing in nucleotides. Also used in the formation of ribavirin chemical delivery systems.

Preparation

can be prepared starting from trichlorosilane by treatment with i-PrMgCl, H2O, and acetyl chloride. Alternatively, it can be prepared by the reaction of 1,1,3,3- tetraisopropyldisiloxane with CCl4 in the presence of catalytic PdCl2.This method is also suitable for its in situ preparation.

1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE Preparation Products And Raw materials

Raw materials

Silanol, 1,1-bis(1-methylethyl)- 1,1,3,3-TETRAISOPROPYLDISILOXANE

Preparation Products

3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)uridine (+)-3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)cytidine 3',5'-TIPS-5-Me-Uridine Adenosine, N-[bis(4-methoxyphenyl)phenylmethyl]-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]- 1-[3,5-O-[1,1,3,3-Tetrakis(1-Methylethyl)-1,3-disiloxanediyl]-β-D-ribofuranosyl]-1H-1,2,4-triazole-3-carboxaMide

1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE Suppliers

Global( 340)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
SURVIVAL TECHNOLOGIES LIMITED +91 8108285261 Gujarat, India 294 58 Inquiry
Lanya Chem Industries Pvt Ltd +91-7290016802 +91-9996207397 Haryana, India 34 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
Alfa Aesar 1 800 209 7001 Maharashtra, India 6913 58 Inquiry
Bhuvar Technologies 09849396291 Mallapur, India 47 58 Inquiry
Triveni chemicals 08048762458 New Delhi, India 6093 58 Inquiry
Chaturya Biotech (Tanuj Life Sciences) 91-7702707258 Hyderabad, India 399 58 Inquiry
Reax Chemicals 08048372701Ext 416 Hyderabad, India 4223 58 Inquiry
Supplier Advantage
SURVIVAL TECHNOLOGIES LIMITED 58
Lanya Chem Industries Pvt Ltd 58
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
TCI Chemicals (India) Pvt. Ltd. 58
Alfa Aesar 58
Bhuvar Technologies 58
Triveni chemicals 58
Chaturya Biotech (Tanuj Life Sciences) 58
Reax Chemicals 58

1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE Spectrum

1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE(69304-37-6)1HNMR1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE(69304-37-6)IR1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE(69304-37-6)Raman1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE(69304-37-6)FT-IR

69304-37-6(1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE)Related Search:

1,1,1,3,3,5,5-HEPTAMETHYLTRISILOXANE 1,3-DIMETHYL-1,1,3,3-TETRAPHENYLDISILAZANE 1,1,3,3-TETRAMETHYL-1,3-DIETHOXYDISILOXANE 1,1,1-triethyl-3,3,3-trimethyldisiloxane 1,1,3,3,5,5-HEXAMETHYLTRISILOXANE
1,1,3,3-TETRAVINYLDIMETHYLDISILOXANE 1,1,3,3-TETRAISOPROPYLDISILOXANE 1,1,3,3-TETRAMETHYLDISILOXANE DIISOPROPYLCHLOROSILANE 1,3-DICHLOROTETRAMETHYLDISILOXANE
1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE Chlorodimethylsilane DIETHYLSILANE 1,1,3,3-TETRACYCLOPENTYLDICHLORODISILOXANE 1,3-dimethyldisiloxane
DIISOPROPYLSILANE METHYLETHYLCHLOROSILANE DIETHYLCHLOROSILANE
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1,3-DICHLORO-1,1,3,3-TETRAISOPROPYL-1,3-DISILOXANE 1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE 1,3-DICHLOROTETRAISOPROPYLSILOXANE 1,1,3,3-Tetraisopropyl-1,3-dichloropropanedisiloxane 1,3-Dichloro-1,1,3,3-tetraisopropylpropanedisiloxane 2,6-Dimethyl-3,5-dichloro-3,5-diisopropyl-4-oxa-3,5-disilaheptane Bis(chlorodiisopropylsilyl) ether 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane,96% 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane ,97% chloro-(chloro-dipropan-2-yl-silyl)oxy-dipropan-2-yl-silane 1,3-DICHLORO-1,1,3,3-TETRAISOPROPYL- 1,3-Dichloro-1,1,3,3-tetraisopropoxydisiloxane 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane [Hydroxyl Protecting Agent] Disiloxane, 1,3-dichloro-1,1,3,3-tetrakis(1-methylethyl)- chloro({[chlorobis(propan-2-yl)silyl]oxy})bis(propan-2-yl)silane 1,3-Dichloro-1,1,3,3-tetrakis(isopropyl)disiloxane 1,3-Dichloro-1,1,3,3-tetrakis(prop-2-yl)disiloxane 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxae 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane, 96% 5ML 1,1,3,3-Tetraisopropyl-1,3-dichlorosiloxane 2,6-DiMethyl-3,5-dichloro 1,1,3,3-tetraisopropyldisiloxanylidene-dichloride 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxan 1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISIL 1,1,3,3-Tetraisopropyl-1,3-dichlorodisiloxane 〔1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane〕 1,1,3,3-TETRAISOPROPYL-1,3-DICH JACS-69304-37-6 1,3-Dichloro-1,1,3,3-tetrakis(isopropyl)disiloxane 97% 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane[HydroxylProtectingAgent]> 1,3-DICHLOROTETRAISOPROPYLDISILOXANE 1,1,3,3-TETRAISOPROPYL-1,3-DICHLORODISILOXANE TIPSCL TIPDSICL2 chloro-[chloro(diisopropyl)silyl]oxy-diisopropyl-silane 1,3-Dichloro-1,1,3,3-tetrakis(1-methylethyl)disiloxane DK365 DK870 1,3-DICHLORO-1,1,3,3- TETRAISOPROPYLDISILOXANE TIPDSiCl2 1,3-dichloro-1,1,3,3-tetraisopropyldimethylsiloxane 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane（TIPSCI） 69304-37-6 C12H28Si2Cl2O CH32CH2SiClOSiClCHCH322 C12H28Cl2OSi2 CH32CH2SiClOClSiCHCH322 Protecting and Derivatizing Reagents Protection and Derivatization Synthetic Reagents Silicon-Based Protection & Derivatization Reagents (for Synthesis) Siloxanes Si-O Compounds Si (Classes of Silicon Compounds) Silicon Compounds (for Synthesis) Si-Cl Compounds Monochlorosilanes DNA / RNA Synthesis Protecting Agents for Hydroxyl Group (DNA/RNA Synthesis)