24(S),25-Epoxycholesterol (not deuterated)
- CAS No.
- 77058-74-3
- Chemical Name:
- 24(S),25-Epoxycholesterol (not deuterated)
- Synonyms
- 24(S);24S,25-EpoxyC;25-epoxycholesterol;(24S)-24,25-Epoxycholestero;(24S)-24,25-Epoxycholesterol;5-CHOLESTEN-24(S), 25-EPOXY-3β-OL;(24S)-24,25-Epoxycholest-5-en-3β-ol;Cholest-5-en-3-ol, 24,25-epoxy-, (3β,24S)-;Cholest-5-en-3-ol, 24,25-epoxy-, (3β,24S)-;24(S),25-Epoxycholesterol (not deuterated)
- CBNumber:
- CB11121024
- Molecular Formula:
- C27H44O2
- Molecular Weight:
- 400.64
- MOL File:
- 77058-74-3.mol
- Modify Date:
- 2024/4/9 20:43:49
| Melting point | 156-157 °C |
|---|---|
| Boiling point | 496.4±18.0 °C(predicted) |
| Density | 1.05 |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 30 mg/ml). |
| form | White solid. |
| pka | 15.03±0.70(predicted) |
| color | White |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months. |
24(S),25-Epoxycholesterol (not deuterated) Chemical Properties,Uses,Production
Description
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain. It activates liver X receptors (LXRs) in the developing ventral midbrain to induce stem cell differentiation into dopaminergic neurons. 24(S),25-epoxy Cholesterol inhibits IL-6 production and degranulation of bone marrow-derived murine mast cells that express LXRβ. It inhibits the conversion of desmosterol to cholesterol by 3β-hydroxysterol Δ24-reductase (DHCR24/Seladin-1) in CHO-7 and SRD-1 cells when used at a concentration of 2.5 μM.
Uses
(24S)-24,25-Epoxycholesterol is a derivative of 4β-Hydroxy Cholesterol (H917980), a metabolite of Cholesterol. It is formed from Cholesterol by the drug-metabolizing enzyme cytochrome P 450 3A4. A potential ligand for the nuclear receptor LXR and also a new endogenous CYP3A marker.
Definition
ChEBI: A 3beta-hydroxy steroid that is desmosterol in which the double bond at position 24-25 has been oxidised to the corresponding epoxide (the 24S diastereoisomer). It is an oxysterol agonist of the liver X receptor.
24(S),25-Epoxycholesterol (not deuterated) Preparation Products And Raw materials
Raw materials
Preparation Products
24(S),25-Epoxycholesterol (not deuterated) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Hu Bei Jiutian Bio-medical Technology CO.,Ltd | 027-88013699 17354350817 | China | 7431 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-400-6206333 18521732826 | China | 25013 | 65 | Inquiry |
| Nantong Hanfang Biotechnology Co. , Ltd. | 18616537568 | China | 30968 | 58 | Inquiry |
| TargetMol Chemicals Inc. | 15002134094 | China | 28118 | 58 | Inquiry |
| SHANGHAI ZZBIO CO., LTD. | 18019219489 19921389125 | China | 12064 | 58 | Inquiry |
| Cayman Chemical Company | (800) 364-9897 | United States | 6618 | 81 | Inquiry |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | China | 9707 | 58 | Inquiry |
| Shenzhen Regent Biochemical Technology Co., Ltd. | 0755-0755-85201366 18938635012 | China | 9305 | 58 | Inquiry |
| Chengdu Push Bio-Technology Co., Ltd. | 18080489829 | China | 9209 | 58 | Inquiry |
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