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(3β,24S)-Cholest-5-ene-3,24-diol

(3β,24S)-Cholest-5-ene-3,24-diol Structure
CAS No.
474-73-7
Chemical Name:
(3β,24S)-Cholest-5-ene-3,24-diol
Synonyms
24-hydroxycholesterol;24(S)-HYDROXYCHOLESTEROL;5-CHOLESTEN-3β, 24(S)-DIOL;cholest-5-ene-3β,24(S)-diol;(24S)-24-hydroxycholesterol;cholest-5-ene-3-beta,24-diol;(3β,24S)-Cholest-5-ene-3,24-diol;(3β,24S)-Cholest-5-ene-3,24-diol;Cholest-5-ene-3,24-diol, (3β,24S)-;24(S)-hydroxycholesterol (24(S)-HC)
CBNumber:
CB6498177
Molecular Formula:
C27H46O2
Molecular Weight:
402.65
MOL File:
474-73-7.mol
MSDS File:
SDS
Modify Date:
2024/8/2 18:12:07
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(3β,24S)-Cholest-5-ene-3,24-diol Properties

Melting point 174-176 °C
Boiling point 513.1±23.0 °C(Predicted)
Density 1.03±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 10 mg/ml).
form powder
pka 15.03±0.70(Predicted)
color white to beige
optical activity [α]/D -45 to -52°, c = 1 in chloroform-d
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.

(3β,24S)-Cholest-5-ene-3,24-diol price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML1648 24(S)-Hydroxycholesterol ≥98% (HPLC) 474-73-7 1MG ₹13628.68 2022-06-14 Buy
Sigma-Aldrich(India) SML1648 24(S)-Hydroxycholesterol ≥98% (HPLC) 474-73-7 5MG ₹55077.6 2022-06-14 Buy
Product number Packaging Price Buy
SML1648 1MG ₹13628.68 Buy
SML1648 5MG ₹55077.6 Buy

(3β,24S)-Cholest-5-ene-3,24-diol Chemical Properties,Uses,Production

Description

24(S)-hydroxy Cholesterol is a side-chain substituted oxysterol that has important roles in cholesterol homeostasis. It is generated by the action of CYP46 on cholesterol in the brain and diffuses across the blood-brain barrier to the systemic circulation where it can modulate cell signaling, be used for further sterol biosynthesis, or be metabolized in the liver. 24(S)-hydroxy cholesterol potently activates LXRα and LXRβ nuclear receptors (EC50 = 4 and 3 μM, respectively), causing upregulation of cholesterol-lowering genes. In the brain, this oxysterol controls cholesterol processing to facilitate neurological repair during Alzheimer’s disease and other neuropathological conditions.

Uses

(3β,24S)-Cholest-5-ene-3,24-diol is used as a biomarker in the analysis of disease.

General Description

24(S)-hydroxycholesterol (24HC) is synthesized from cholesterol in brain dendrites by the action of enzyme cholesterol 24-hydroxylase (CYP46A1). It is catabolized to bile acids in the liver.

(3β,24S)-Cholest-5-ene-3,24-diol Preparation Products And Raw materials

Raw materials

Preparation Products

(3β,24S)-Cholest-5-ene-3,24-diol Suppliers

Global( 53)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Shaanxi Dideu Medichem Co. Ltd 18192627656 China 2303 58 Inquiry
Labnetwork lnc. +86-27-50766799 +8618062016861 China 19994 58 Inquiry
LEAPCHEM CO., LTD. +86-852-30606658 China 43348 58 Inquiry
Shanghai Acmec Biochemical Technology Co., Ltd. +undefined18621343501 China 33350 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 52927 58 Inquiry
RD International Technology Co., Limited 18024082417 China 9282 58 Inquiry
SHANGHAI ZZBIO CO., LTD. 18019219489 19921389125 China 12064 58 Inquiry
Guangzhou Younan Technology Co., Ltd 020-020-82000279 18988968278 China 4325 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Shaanxi Dideu Medichem Co. Ltd 58
Labnetwork lnc. 58
LEAPCHEM CO., LTD. 58
Shanghai Acmec Biochemical Technology Co., Ltd. 58
Aladdin Scientific 58
RD International Technology Co., Limited 58
SHANGHAI ZZBIO CO., LTD. 58
Guangzhou Younan Technology Co., Ltd 58

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(3S,8S,9S,10R,13R,14S,17R)-17-[(1R,4S)-4-hydroxy-1,5-dimethyl-hexyl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol 24-hydroxycholesterol cholest-5-ene-3-beta,24-diol (3S,8S,9S,10R,13R,14S,17R)-17-[(2R,5S)-5-hydroxy-6-methyl-heptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol cholest-5-ene-3β,24(S)-diol CHOLEST-5-ENE-3Β,24(S)-DIOL;24(S)-HYDROXYCHOLESTEROL (24S)-24-hydroxycholesterol 24(S)-HYDROXYCHOLESTEROL (3β,24S)-Cholest-5-ene-3,24-diol 24(S)-hydroxycholesterol (24(S)-HC) (8S,9S,10R,13R,14S,17R)-17-[(2R,5S)-5-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol Cholest-5-ene-3,24-diol, (3β,24S)- (3β,24S)-Cholest-5-ene-3,24-diol 5-CHOLESTEN-3β, 24(S)-DIOL 474-73-7 Pharmaceutical Raw Materials Diagnostic