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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Apoptosis >PERK activator >SALUBRINAL

SALUBRINAL

SALUBRINAL Structure
CAS No.
405060-95-9
Chemical Name:
SALUBRINAL
Synonyms
SAL;CS-1008;ubrinaL;SALUBRINAL;EIF-2Α INHIBITOR;SALUBRINAL USP/EP/BP;N-(2,2,2-Trichloro-1-(3-(quinolin-8-yl)thioureido)ethyl)cinnAmamide;(E)-1-(quinolin-8-yl)-3-(2,2,2-trichloro-1-cinnamamidoethyl)thiourea;(E)-N-(2,2,2-Trichloro-1-(3-(quinolin-8-yl)thioureido)ethyl)cinnamamide;(E)-3-phenyl-N-[2,2,2-trichloro-1-(quinolin-8-ylcarbamothioylamino)ethyl]prop-2-enamide
CBNumber:
CB3322523
Molecular Formula:
C21H17Cl3N4OS
Molecular Weight:
479.81
MOL File:
405060-95-9.mol
MSDS File:
SDS
Modify Date:
2023/6/30 15:45:59
Request For Quotation

SALUBRINAL Properties

Melting point >160°C (dec.)
Density 1.474±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO: soluble20mg/mL, clear
form powder
pka 10.70±0.70(Predicted)
color white to light yellow to light gray
Water Solubility Insoluble in water.
Sensitive Light Sensitive
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26
WGK Germany  3
NFPA 704
0
2 0

SALUBRINAL price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML0951 Salubrinal ≥98% (HPLC) 405060-95-9 5MG ₹11420.38 2022-06-14 Buy
Sigma-Aldrich(India) SML0951 Salubrinal ≥98% (HPLC) 405060-95-9 25MG ₹46515.03 2022-06-14 Buy
Product number Packaging Price Buy
SML0951 5MG ₹11420.38 Buy
SML0951 25MG ₹46515.03 Buy

SALUBRINAL Chemical Properties,Uses,Production

Description

Salubrinal is a selective phosphatase inhibitor that prevents dephosphorylation of eukaryotic translation initiation factor 2 subunit α (eIF2α), protecting PC12 cells from endoplasmic reticulum stress-mediated apoptosis (EC50 = 15 μM). It appears to block the action of protein phosphatase 1 (PP1) on eIF2α although it does not mimic calyculin A, another PP1-selective inhibitor, in toxicity or phosphorylation pattern. Salubrinal also prevents replication of herpes virus (IC50 = 3 μM), by inhibiting dephosphorylation of eIF2α. As eIF2α has a role in bone formation, salubrinal is being studied for its effects in osteoporosis.

Uses

Salubrinal is an endoplasmic reticulum stress blocker that modulates sleep homeostasis and activation of sleep- and wake-regulatory neurons

Definition

ChEBI: A member of the class of quinolines that is a mixed aminal resulting from the formal condensation oftrichloroacetaldehyde with the amide nitrogen of trans-cinnamamide and the primary amino group of 1-quinolin-8-ylthiourea. It is a selective in ibitor of cellular complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha).

Biological Activity

Cell-permeable, selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2 α ). Protects cells from endoplasmic reticulum stress-induced apoptosis (EC 50 ~ 15 μ M).

SALUBRINAL Preparation Products And Raw materials

Raw materials

Preparation Products

SALUBRINAL Suppliers

Global( 118)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
SHANGHAI T&W PHARMACEUTICAL CO., LTD. +86-021-61551413 +8618813727289 China 5738 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 26216 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
LEAP CHEM CO., LTD. +86-852-30606658 China 24738 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
Zibo Hangyu Biotechnology Development Co., Ltd +86-0533-2185556 +8617865335152 China 11027 58 Inquiry
Supplier Advantage
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 58
Dideu Industries Group Limited 58
InvivoChem 58
LEAP CHEM CO., LTD. 58
TargetMol Chemicals Inc. 58
Zibo Hangyu Biotechnology Development Co., Ltd 58

SALUBRINAL Spectrum

SALUBRINAL(405060-95-9)1HNMR

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(2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide 2-Propenamide, 3-phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-, (2E)- (2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide Salubrinal Salubrinal (2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide (E)-3-phenyl-N-[2,2,2-trichloro-1-(quinolin-8-ylcarbamothioylamino)ethyl]prop-2-enamide N-(2,2,2-Trichloro-1-(3-(quinolin-8-yl)thioureido)ethyl)cinnAmamide SALUBRINAL SAL 3-PHENYL-N-[2,2,2-TRICHLORO-1-[[(8-QUINOLINYLAMINO)THIOXOMETHYL]AMINO]ETHYL]-2-PROPENAMIDE (E)-1-(quinolin-8-yl)-3-(2,2,2-trichloro-1-cinnamamidoethyl)thiourea EIF-2Α INHIBITOR CS-1008 ubrinaL SALUBRINAL USP/EP/BP (E)-N-(2,2,2-Trichloro-1-(3-(quinolin-8-yl)thioureido)ethyl)cinnamamide 405060-95-9 C21H17Cl3N4OS C21H17N4OSCl3 Inhibitors Apoptosis Inhibitors