T0901317

CAS No.: 293754-55-9

Chemical Name:: T0901317

Synonyms: CS-721;T 1317;T0901317;TO091317;TO-91317;TO-901317;TO 091317;TO-091317;T0901317 (T-1317);T0901317 293754-55-9

CBNumber:: CB0368768

Molecular Formula:: C17H12F9NO3S

Molecular Weight:: 481.33

MOL File:: 293754-55-9.mol

MSDS File:: SDS

Modify Date:: 2025/1/27 9:38:02

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T0901317 Properties

Melting point	116-118°C
Boiling point	470.5±55.0 °C(Predicted)
Density	1.550±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO (Slightly), Methanol (Slightly)
pka	9.00±0.15(Predicted)
form	Light beige solid
color	Off-White
InChIKey	SGIWFELWJPNFDH-UHFFFAOYSA-N

SAFETY

Risk and Safety Statements

WGK Germany	3

T0901317 price More Price(3)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	T2320	T0901317 ≥98%	293754-55-9	5MG	₹6917.18	2022-06-14	Buy
Sigma-Aldrich(India)	T2320	T0901317 ≥98%	293754-55-9	10MG	₹11063.15	2022-06-14	Buy
Sigma-Aldrich(India)	575310	T0901317 - CAS 293754-55-9 - Calbiochem A cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC?? of 20 nM for LXRα).	293754-55-9	10MG	₹18990	2022-06-14	Buy

Product number	Packaging	Price	Buy
T2320	5MG	₹6917.18	Buy
T2320	10MG	₹11063.15	Buy
575310	10MG	₹18990	Buy

T0901317 Chemical Properties,Uses,Production

Uses

The Liver X Receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands are oxysterols, such as 22(R)-hydroxycholesterol. The LXRs regulate the oxysterol-induced expression of cholesterol 7α-hydroxylase, the rate limiting enzyme of classic bile acid synthesis. T0901317 is a potent and selective agonist for both LXRα and LXRβ, with an EC50 of about 50 nM. T0901317 acting through LXR and in concert with its RXR heterodimerization partner induces the expression of the ABCA1 reverse cholesterol transporter. This acts to increase the efflux of cholesterol from enterocytes and thus inhibit the overall absorption of cholesterol.

General Description

A cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC₅₀ = 20 nM for LXRα). Reported to induce the expression of genes associated with fatty acid biosynthesis. Raises the levels of serum HDL cholesterol and triglycerides in mice and inhibits the development of atherosclerosis in LDL receptor-deficient mice. Also shown to lower plasma glucose levels in diabetic rodents.

Biological Activity

Potent, high affinity liver X receptor (LXR) agonist (EC 50 ~ 50 nM, Kd values are 7 and 22 nM for LXR- α and LRXR- β respectively). Upregulates expression of the ABCA1 gene associated with cholesterol efflux regulation and HDL metabolism. Decreases amyloid- β production in primary neurons in vitro . Displays an EC 50 of ~ 5 μ M for activation of bile acid farnesoid X receptors (FXRs); 10-fold more potent than natural FXR ligand chenodeoxycholic acid.

T0901317 Preparation Products And Raw materials

Raw materials

Preparation Products

T0901317 Suppliers

Global( 145)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6100	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6257	58	Inquiry
Hebei Mujin Biotechnology Co.,Ltd	+86 13288715578 +8613288715578	China	12809	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	33024	60	Inquiry
BOC Sciences	+1-631-485-4226	United States	19552	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	32159	58	Inquiry
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	China	30231	58	Inquiry
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	China	10473	58	Inquiry
CR Corporation Limited	+8613062833949	China	8647	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6391	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
Hebei Mujin Biotechnology Co.,Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
BOC Sciences	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Zhejiang J&C Biological Technology Co.,Limited	58
CR Corporation Limited	58
InvivoChem	58

T0901317 Spectrum

T0901317(293754-55-9)¹HNMR

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N-(2,2,2-TRIFLUOROETHYL)-N-[4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL]BENZENESULFONAMIDE T0901317 TO-901317 BenzenesulfonaMide, N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoroMethyl)ethyl]phenyl]- T 1317 T0901317;T 0901317; T-0901317 N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl] T0901317 - CAS 293754-55-9 - Calbiochem CS-721 T0901317 (T-1317) N-(2,2,2-trifluoroethyl) N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-(2,2,2-trifluoroethyl)benzenesulfonamide T0901317 293754-55-9 N-(2,2,2-Trifluoroethyl)-N-4-2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethylphenylbenzenesulfonamide TO 091317 TO091317 TO-091317 TO-91317 T0901317, LXR agonist T0901317, 10 mM in DMSO 293754-55-9 C17H12NSO3F9 C17H12F9NO3S Cell Signaling and Neuroscience Cell Biology BioChemical PPAR and RXR Regulators Gene Regulation and Expression PPAR and RXR Regulators Cell Signaling and Neuroscience Gene Regulation and Expression Inhibitors