T0901317
T0901317
- CAS:
- 293754-55-9
- MF:
- C17H12F9NO3S
- MW:
- 481.33
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Properties
- Melting point:
- 116-118°C
- Boiling point:
- 470.5±55.0 °C(Predicted)
- Density
- 1.550±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 9.00±0.15(Predicted)
- form
- Light beige solid
- color
- Off-White
- InChIKey
- SGIWFELWJPNFDH-UHFFFAOYSA-N
Safety Information
- WGK Germany
- 3
Use
The Liver X Receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands are oxysterols, such as 22(R)-hydroxycholesterol. The LXRs regulate the oxysterol-induced expression of cholesterol 7α-hydroxylase, the rate limiting enzyme of classic bile acid synthesis. T0901317 is a potent and selective agonist for both LXRα and LXRβ, with an EC50 of about 50 nM. T0901317 acting through LXR and in concert with its RXR heterodimerization partner induces the expression of the ABCA1 reverse cholesterol transporter. This acts to increase the efflux of cholesterol from enterocytes and thus inhibit the overall absorption of cholesterol.
0 India supplier list of "T0901317"
- Product Name:T0901317-CAS293754-55-9-Calbiochem
- Products Intro:Brand:sigma aldrich | Product Number:575310 | Purity:Acell-permeable,nonsterol,benzenesulfonamidecompoundthatactsasahighlyselectivean
- Company Type: Trader
- Country/Region: INDIA
- Product Name:T0901317
- Products Intro:Brand:ajchemicals | Product Number:JDH-36701 | Purity:95+%
- Company Type: Trader
- Country/Region: INDIA
- Product Name:T0901317
- Products Intro:Brand:clearsynth | Product Number:CS-T-43059
- Company Type: Trader
- Country/Region: INDIA
- Product Name:T0901317
- Products Intro:Purity: 98% | Package: 10MG;50MG;100MG,1G,5G,10G.100G
- Company Type: Reagent
- Country/Region: CHINA
- Product Name:T0901317
- Products Intro:Purity: >98% | Package: 300mg | CustNote: BOC Sciences also provides custom synthesis services for T0901317.
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:T0901317
- Products Intro:Purity: 95.0% windy 23
- Company Type: Trader
- Country/Region: CHINA
- Product Name:T0901317
- Products Intro:Purity: 99% | Package: 5KG;1KG | CustNote: T0901317
- Company Type: Trader
- Country/Region: CHINA
- Product Name:T0901317
- Company Type: Trader
- Country/Region: CHINA
- Product Name:T0901317
- Products Intro:Package: 1 mL * 10mM (in DMSO)；10 mg；100 mg；200 mg；25 mg；50 mg | CustNote: REAGENT;FOR LABORATORY USE ONLY
- Company Type: Reagent
- Country/Region: UNITED STATES