Homatropine Hydrobromide
- CAS No.
- 51-56-9
- Chemical Name:
- Homatropine Hydrobromide
- Synonyms
- DL-Hydrobromide;r,hbr,endo-(+-);Homatropine HBr;HoMatropineHBrUSP;Isopto Homatropine;Homatropinhydrobromid;endo-(+/-)-hydrobromid;(+-)-homatropinebromide;HOMATROPINE HYDROBROMIDE;HomatropineHydrobromideGr
- CBNumber:
- CB1185212
- Molecular Formula:
- C16H22BrNO3
- Molecular Weight:
- 356.25
- MOL File:
- 51-56-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:00
| Melting point | 214-217 °C |
|---|---|
| storage temp. | 2-8°C |
| solubility | Freely soluble in water, sparingly soluble in alcohol. |
| form | Solid |
| color | White to Off-White |
| Water Solubility | soluble |
| Merck | 14,4730 |
| CAS DataBase Reference | 51-56-9(CAS DataBase Reference) |
| EPA Substance Registry System | Homatropine hydrobromide (51-56-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H332-H312 | |||||||||
| Precautionary statements | P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 23/24/25 | |||||||||
| Safety Statements | 45-24/25-22 | |||||||||
| RIDADR | 1544 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | YM5602000 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29399900 | |||||||||
| NFPA 704 |
|
Homatropine Hydrobromide price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR3182 | Homatropine Hydrobromide pharmaceutical secondary standard, certified reference material | 51-56-9 | 500MG | ₹18380.85 | 2022-06-14 | Buy |
| ottokemi | H 1426 | Homatropine hydrobromide, GR 99% 99% | 51-56-9 | 1gm | ₹3591 | 2022-05-26 | Buy |
| ottokemi | H 1426 | Homatropine hydrobromide, GR 99% 99% | 51-56-9 | 25gm | ₹27099 | 2022-05-26 | Buy |
Homatropine Hydrobromide Chemical Properties,Uses,Production
Description
Homatropine is an anticholinergic agent. It reduces acetylcholine-induced contractions of isolated goat detrusor muscle strips when used at a concentration of 5 μM. Homatropine (1 μM) inhibits acetylcholine- or methacholine-induced contraction of isolated rat anococcygeus muscle. It inhibits serotonin- or thrombin-induced platelet aggregation in isolated sheep platelet-rich plasma (IC50s = 4.3 and 100 μM, respectively). Topical ophthalmic administration of homatropine induces partial mydriasis in Angora goats.
Chemical Properties
white crystals or crystalline powder
Uses
Homatropine is an anticholinergic agent. Homatropine acts as an inhibitor of the muscarinic acetylcholine receptors. Homatropine is used in eye drops as a cycloplegic and as a mydriatic, to dilate the pupil.
General Description
Homatropine hydrobromide,1 H,5 H-tropan-3 -ol mandelate (ester) hydrobromide(Homatrocel), occurs as white crystals or as awhite, crystalline powder that is affected by light. It is solublein water (1:6) and alcohol (1:40), less soluble in chloroform(1:420), and insoluble in ether.
Solutions are incompatible with alkaline substances,which precipitate the free base, and with the commonreagents that precipitate alkaloids. As with atropine, solutionsare sterilized best by filtration through a bacteriologicalfilter.
Clinical Use
Homatropine hydrobromide is used topically to paralyzethe ciliary structure of the eye (cycloplegia) and to effectmydriasis. It behaves very much like atropine but is weakerand less toxic. In the eye, it acts more rapidly but less persistentlythan atropine. Dilation of the pupil takes place inabout 15 to 20 minutes, and the action subsides in about24 hours. By using a miotic, such as physostigmine, it ispossible to restore the pupil to normality in a few hours.
Homatropine Hydrobromide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| RESONANCE LABS | +91-8027630180 +91-8027630180 | Karnataka, India | 32 | 58 | Inquiry |
| Otto Chemie Pvt Ltd | +91-2222070099 +91-2266382599 | Maharashtra, India | 429 | 58 | Inquiry |
| R L Fine Chem Pvt. Ltd | +91-8042488999 +91-8042488999 | Karnataka, India | 74 | 58 | Inquiry |
| Flowchem Pharma Pvt Ltd | +91-9606036218 +91-9845055636 | Karnataka, India | 33 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Sanvin Group of Companies (Pioneer Agro Industries) | +91-2261066638 +91-2261066600 | Maharashtra, India | 27 | 58 | Inquiry |
| Saurav Chemicals Ltd | +91-1725054817 +91-1725054817 | Haryana, India | 20 | 58 | Inquiry |
| Bhavna Laboratories Pvt. Ltd. | 08048361296Ext 328 | Mumbai, India | 10 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Oxford laboratories | +91 250 239 0032 | Maharashtra, India | 652 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| RESONANCE LABS | 58 |
| Otto Chemie Pvt Ltd | 58 |
| R L Fine Chem Pvt. Ltd | 58 |
| Flowchem Pharma Pvt Ltd | 58 |
| Ralington Pharma | 58 |
| Sanvin Group of Companies (Pioneer Agro Industries) | 58 |
| Saurav Chemicals Ltd | 58 |
| Bhavna Laboratories Pvt. Ltd. | 58 |
| Pharma Affiliates | 58 |
| Oxford laboratories | 58 |
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