ChemicalBook > Product Catalog >Biochemical Engineering >Protein Research >Protease inhibitors >TLCK
TLCK
- CAS No.
- 4272-74-6
- Chemical Name:
- TLCK
- Synonyms
- TLCK;TLCK HCL;(s)-lorid;TOS-LYS-CMK;TOSYL-LYS-CMK;TLCK USP/EP/BP;TOS-LYS-CMK HCL;Tos-L-Lys-CMK·HCl;TLCK HYDROCHLORIDE;Tos-Lys-chloromethylketone
- CBNumber:
- CB1197729
- Molecular Formula:
- C14H22Cl2N2O3S
- Molecular Weight:
- 369.31
- MOL File:
- 4272-74-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/8 9:02:10
| Melting point | ~165 °C (dec.) |
|---|---|
| storage temp. | -20°C |
| solubility | H2O: 50 mg/mL |
| form | powder |
| color | white to pink |
| optical activity | [α]20/D 7.8±0.5°, c = 2% in H2O |
| BRN | 7106867 |
| CAS DataBase Reference | 4272-74-6 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P302+P352-P304+P340-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | UN 3335 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | XT5160000 | |||||||||
| F | 10-21 | |||||||||
| HS Code | 29350090 | |||||||||
| NFPA 704 |
|
TLCK price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | T7254 | Nα-Tosyl-L-lysine chloromethyl ketone hydrochloride ≥96% (TLC), powder | 4272-74-6 | 100MG | ₹12156.48 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T7254 | Nα-Tosyl-L-lysine chloromethyl ketone hydrochloride ≥96% (TLC), powder | 4272-74-6 | 500MG | ₹42715.45 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T7254 | Nα-Tosyl-L-lysine chloromethyl ketone hydrochloride ≥96% (TLC), powder | 4272-74-6 | 1G | ₹86069.58 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 90182 | Nα-Tosyl-L-lysine chloromethyl ketone hydrochloride ≥99.0% (AT) | 4272-74-6 | 100MG | ₹12870.93 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 90182 | Nα-Tosyl-L-lysine chloromethyl ketone hydrochloride ≥99.0% (AT) | 4272-74-6 | 500MG | ₹50693.48 | 2022-06-14 | Buy |
TLCK Chemical Properties,Uses,Production
Chemical Properties
white to light beige powder
Uses
Tosyllysine chloromethylketone (TLCK) is an active site-directed agent that inhibits serine proteinases with trypsin-like activity. TLCK may also act non-selectively with thiol groups and thereby inhibit cysteine proteinases and other enzymes. To prevent proteolytic degradation, TLCK may be used in protein purification protocols. TLCK selectively inactiviates clostripain obtained from C. histolyticum.
Purification Methods
The hydrochloride slowly crystallises from a concentrated solution in absolute EtOH, thinned with EtOH/Et2O for collection and dried in vacuo. It is a suicide enzyme inhibitor of serine proteases, e.g. trypsin and clostripain. [Matsuda et al. Chem Pharm Bull Jpn 30 2512 1982, Shaw et al. Biochemistry 4 2219 1965].
TLCK Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 75)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29896 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24407 | 58 | Inquiry |
| BOC Sciences | 16314854226; +16314854226 | United States | 19743 | 58 | Inquiry |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | China | 52861 | 58 | Inquiry |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | China | 19915 | 58 | Inquiry |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | China | 49999 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| A.J Chemicals | 58 |
| Alfa Aesar | 58 |
| career henan chemical co | 58 |
| Chongqing Chemdad Co., Ltd | 58 |
| TargetMol Chemicals Inc. | 58 |
| Dideu Industries Group Limited | 58 |
| BOC Sciences | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 58 |
| Nextpeptide Inc | 58 |
| GIHI CHEMICALS CO.,LIMITED | 58 |
4272-74-6(TLCK)Related Search:
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N-TOSYL-LYS-CHLOROMETHYLKETONE
TOS-LYS-CHLOROMETHYLKETONE HCL
TOS-LYS-CMK
TOS-LYS-CMK HCL
TOSYL-L-LYSINE CHLOROMETHYLKETONE HCL
TOSYL-LYS-CMK
TOSYL-L-LYSYL-CHLOROMETHANE HCL
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Benzenesulfonamide,N-[(1S)-5-amino-1-(2-chloroacetyl)pentyl]-4-methyl-, hydrochloride (1:1)
Tosyl-L-lysyl-chloromethane hydrochloride
Nα-Tosyl-L-lysine chloromethylketone hydrochloride≥ 98% (HPLC)
Tos-L-Lys-CMK·HCl
L-1-CHLORO-3-TOSYLAMIDO-7-AMINO-2-HEPTANONE HCL
L-1-CHLORO-3-(4-TOSYLAMIDO)-7-AMINO-2-HEPTANONE HYDROCHLORIDE
(3S)-7-AMINO-1-CHLORO-3-TOSYLAMINO-2-HEPTANONE HYDROCHLORIDE
(3S)-1-CHLORO-3-TOSYLAMIDO-7-AMINO-2-HEPTANONE HYDROCHLORIDE
1-CHLORO-3-TOSYLAMIDO-7-AMINO-2-HEPTANONE HYDROCHLORIDE
1-CHLORO-3-TOSYLAMIDO-7-AMINO-L-2-HEPTANONE
1-CHLORO-3-TOSYLAMIDO-7-AMINO-L-2-HEPTANONE HYDROCHLORIDE
Chloro-3-tosylaMido-7-aMino-2-heptanone-HCl research grade
n-(5-amino-1-(chloroacetyl)pentyl)-4-methyl-benzenesulfonamidmonohydroch
(S)-N-[5-amino-1-(chloroacetyl)pentyl]-p-toluenesulphonamide monohydrochloride
Benzenesulfonamide, N-(1S)-5-amino-1-(chloroacetyl)pentyl-4-methyl-, monohydrochloride
NALPHA-TOSYL-L-LYSINE CHLOROMETHYL KETONE HYDROCHLORIDE (TLCK)
(3S)-1-Chloro-3-tosylamido-7-amino-2-heptanone hydrochloride,98%
Tos-Lys-chloromethylketone
(3S)-1-Chloro-3-tosylaMido-7-aMino-2-heptanone hydrochloride, 98% 50MG
Nα-Tosyl-L-lysine chloroMethyl ketone HCl
(s)-lorid
l-n-(5-amino-1-(chloroacetyl)pentyl)-p-toluenesulfonamidehydrochloride
n-(5-amino-1-(chloroacetyl)pentyl)-,hydrochloride,l-p-toluenesulfonamid
TLCK
TLCK HCL
TLCK HYDROCHLORIDE
N-ALPHA-TOSYL-L-LYS CHLOROMETHYLKETONE
N-ALPHA-TOSYL-L-LYSINE CHLOROMETHYL KETONE HYDROCHLORIDE
N-ALPHA-TOSYL-LYS-CHLOROMETHYLKETONE HCL
Nα-Tosyl-L-lysine chloromethyl ketone hydrochloride
N-alpha-Tosyl-L-lysine chloromethyl ketone HCl
TLCK USP/EP/BP
(3S)-1-Chloro-3-tosylamido-7-amino-2-heptanone HCl
Nα-Tosyl-L-lysine chloromethyl ketone
N-ALPHA-TOSYL-L-LYSINE CHLOROMETHYL KETONE
N-ALPHA-TOSYL-L-LYSINE CHLOROMETHYL KETONE (TLCK)
Inhibitor,inhibit,N alpha Tosyl L lysine chloromethyl ketone hydrochloride,NalphaTosylLlysine chloromethyl ketone hydrochloride
4272-74-6
C14H21ClN2O3SHCl
C14H21ClN2O3S
C14H22N2O3Scl
Organic Covalent Modifiers
BioChemical
Biochemicals and Reagents