α-MSH (11-13) (free acid)
- CAS No.
- 67727-97-3
- Chemical Name:
- α-MSH (11-13) (free acid)
- Synonyms
- KPV;msh(11-13;Lys-pro-val;ACTH-(11-13);H-Lys-Pro-Val-OH;ALPHA-MSH (11-13);α-MSH(11-13)[pig];α-MSH(11-13)[human];H-LYS-PRO-VAL-OH ACOH;α-Melanotropin(11-13)
- CBNumber:
- CB1241534
- Molecular Formula:
- C16H30N4O4
- Molecular Weight:
- 342.43
- MOL File:
- 67727-97-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/4/17 18:22:24
| storage temp. | -15°C |
|---|---|
| InChI | InChI=1S/C16H30N4O4/c1-10(2)13(16(23)24)19-14(21)12-7-5-9-20(12)15(22)11(18)6-3-4-8-17/h10-13H,3-9,17-18H2,1-2H3,(H,19,21)(H,23,24)/t11-,12-,13-/m0/s1 |
| InChIKey | YSPZCHGIWAQVKQ-AVGNSLFASA-N |
| SMILES | C(O)(=O)[C@H](C(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)N |
α-MSH (11-13) (free acid) Chemical Properties,Uses,Production
Description
α-MSH (11-13) (free acid) is a synthetic, nonsteroidal compound that binds to and activates α-melanocyte-stimulating hormone receptors. It has been used as an antiinflammatory agent in the treatment of inflammatory bowel disease and bowel disease. It is also being studied as a contraceptive and an elastase inhibitor. This drug has shown some promise in the treatment of autoimmune diseases, such as rheumatoid arthritis, Crohn's disease, ulcerative colitis, multiple sclerosis, and type 1 diabetes mellitus. It is thought that α-MSH (11-13) (free acid) acetate salt may inhibit the production of inflammatory cells by inhibiting leukocyte elastase activity.
Biological Activity
The C-terminal tripeptide α-MSH(11–13), also known as KPV (L-Lys-L-Pro-L-Val), exhibited anti-inflammation without induction of cutaneous pigmentation in a frog skin bioassay. The underlying molecular mechanisms of the α-MSH(11–13) anti-inflammatory properties have not been determined in detail. However, they are related to an inhibition of TNF-α, IL-6, and nitric oxide production in a model of LPS-stimulated murine microglial cell culture[1]. Furthermore, it has been recently shown that α-MSH(11–13) reduces activation of NF-κB and decreases its translocation into the nucleus by interaction with importin family proteins.
References
[1] Eva-Verena Schaible. “Single administration of tripeptide α-MSH(11-13) attenuates brain damage by reduced inflammation and apoptosis after experimental traumatic brain injury in mice.” PLoS ONE (2013): e71056.
α-MSH (11-13) (free acid) Preparation Products And Raw materials
Raw materials
Preparation Products
α-MSH (11-13) (free acid) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Hebei Weimiao Import and Export Trade Co., Ltd. | +86-19948166995 +86-19948166995 | China | 76 | 58 | Inquiry |
| Hebei Xunou new energy Technology Co., LTD | +86-17531957005; +undefined17531957005 | China | 36 | 58 | Inquiry |
| Sea Biological Co.,LTD | +86-13865152372 +86-13865152372 | China | 71 | 58 | Inquiry |
| Shanghai Affida new material science and technology center | +undefined15081010295 | China | 114 | 58 | Inquiry |
| Shenzhen Aoxi Technology Co., Ltd. | +852-46424790 +852-46424790 | China | 135 | 58 | Inquiry |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | China | 10983 | 58 | Inquiry |
| Hebei Xinsheng New Material Technology Co., LTD. | +86-16632316109 | China | 1085 | 58 | Inquiry |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | China | 615 | 58 | Inquiry |
| Hangzhou Hyper Chemicals Limited | +86-0086-57187702781 +8613675893055 | China | 295 | 58 | Inquiry |
| Shanghai Getian Industrial Co., LTD | +86-15373193816 +86-15373193816 | China | 269 | 58 | Inquiry |
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