ALPHA-MSH | 581-05-5

ALPHA-MSH Properties

Density	1.48±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	insoluble in EtOH; ≥10.44 mg/mL in H2O with ultrasonic; ≥166.5 mg/mL in DMSO with gentle warming
pka	4.43±0.10(Predicted)
form	Lyophilized
color	White to off-white
Water Solubility	Soluble in water (~1 mg/ml).
BRN	741840

SAFETY

Risk and Safety Statements

Safety Statements	22-24/25
WGK Germany	3

ALPHA-MSH price More Price(3)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	M4135	α-Melanocyte stimulating hormone ≥97% (HPLC)	581-05-5	1MG	₹12351.33	2022-06-14	Buy
Sigma-Aldrich(India)	M4135	α-Melanocyte stimulating hormone ≥97% (HPLC)	581-05-5	5MG	₹38905.05	2022-06-14	Buy
Sigma-Aldrich(India)	05-23-0751	α-Melanocyte-Stimulating Hormone Synthetic α-melanocyte-stimulating hormone.	581-05-5	1MG	₹8270	2022-06-14	Buy

Product number	Packaging	Price	Buy
M4135	1MG	₹12351.33	Buy
M4135	5MG	₹38905.05	Buy
05-23-0751	1MG	₹8270	Buy

ALPHA-MSH Chemical Properties,Uses,Production

Uses

alpha-Melanocyte Stimulating Hormone amide is an endogenous melanocortin receptor agonist (Ki values are 0.12, 31, 660 and 5700 nM for MC1, MC3, MC4 and MC5 receptors respectively). Anti-inflammatory peptide; antagonizes proinflammatory mediators, including TNF-α, IL-6 and NO and induces anti-inflammatory cytokine IL-10. Inhibits food intake and induces penile erections following i.c.v. administration.

General Description

α-Melanocyte-stimulating hormone (α-MSH) is a tridecapeptide, mostly produced by the cells in the brain, pituitary and circulation. Pro-inflammatory cytokines or UV light induced epidermal cells such as keratinocytes and melanocytes synthesize and discharge α–MSH. Poopiomelanocortin (POMC) acts as a precursor for α-Melanocyte-stimulating hormone (α-MSH) production.

Purification Methods

Its solubility in H2O is 1mg/mL. It is separated from the extract by ion-exchange on carboxymethyl cellulose, desalted, evaporated and lyophilised, then chromatographed on Sephadex G-25. [Lande et al. Biochemical Preparations 13 45 1971.]

Structure and conformation

Three types of MSH molecules, with different amino acid sequences, are contained in the common precursor POMC in mammals. α-Melanocyte-stimulating hormone (α-MSH) is composed of 13 aa residues. This peptide is generated from the N-terminal region of the adrenocorticotropic hormone (ACTH), and corresponds to acetylACTH(1–13)-amide. In MSH, the N-terminal Ser residue is free, monoacetylated at the N position, or diacetylated at the N and O positions, whereas the carboxyl terminal is consistently in the amide form. These variations of MSH are called desacetyl-α-MSH, α-MSH, and diacetyl-α-MSH, respectively. Of these peptides, α-MSH is a classical α-MSH. β-MSH, which is generated from POMC via β-lipotropin (β-LPH), is composed of 18 aa residues. Unlike α-MSH, in β-MSH both termini are free. γ-MSH is produced from POMC via pro-γ-MSH or N-POMC, which consists of γ-MSH together with a joining peptide. γ-MSH (also known as γ1-MSH) is composed of 12 aa residues in which the N-terminus and the C-terminus are free and amide, respectively. γ3-MSH is composed of 25 aa residues in which the N-terminal region corresponds to γ1-MSH. Each MSH segment is flanked by basic amino acid residues. Cartilaginous fish such as sharks, rays, and ratfish possess δ-MSH in addition to the three other MSH peptides. Comparison with the amino acid sequence and topology of POMC suggests that δ-MSH might have evolved from β-MSH. Accordingly, α-MSH and γ-MSH are suggested to share an antecedent. Teleost POMC lacks γ-MSH.
ALPHA-MSH

ALPHA-MSH Preparation Products And Raw materials

Raw materials

Preparation Products

ALPHA-MSH Suppliers

Global( 184)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Hangzhou ICH Biofarm Co., Ltd	+86-0571-28186870; +undefined8613073685410	China	1015	58	Inquiry
Wuhan Haorong Biotechnology Co.,ltd	+86-18565342920; +8618565342920	China	307	58	Inquiry
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-+86-371-66670886	China	19805	58	Inquiry
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	China	10406	58	Inquiry
BOC Sciences	+1-631-485-4226	United States	19552	58	Inquiry
Shanghai Longyu Biotechnology Co., Ltd.	+8619521488211	China	2555	58	Inquiry
Cellmano Biotech Limited	0551-65326643 18156095617	China	995	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29808	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	32159	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	22854	58	Inquiry

Supplier	Advantage
Hangzhou ICH Biofarm Co., Ltd	58
Wuhan Haorong Biotechnology Co.,ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Shenzhen Nexconn Pharmatechs Ltd	58
BOC Sciences	58
Shanghai Longyu Biotechnology Co., Ltd.	58
Cellmano Biotech Limited	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58

ALPHA-MSH Spectrum

ALPHA-MSH(581-05-5)MS

581-05-5(ALPHA-MSH)Related Search:

α-MSH (11-13) (free acid) α-MSH (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt) alpha-MSH (1-13), Val(13)-,[VAL-OH13]-ALPHA-MSH,val(13)-alpha-msh(1-1 ALPHA-MSH (11-13) . 2 HCL [N-ACETYL-NLE4,ASP5,D-PHE7,LYS10]-ALPHA-MSH (4-10) AMIDE ASP5-LYS10, CYCLIC LACTAM

ALPHA-MSH Melanotan 1 (D-TRP7,ALA8,D-PHE10)-ALPHA-MSH (6-11) AMIDE (DES-ALA8,D-ALA6,D-2-NAL7,D-PHE10)-ALPHA-MSH (6-11) AMIDE [DI-AC]-ALPHA-MSH,(DIACETYL)-ALPHA-MSH,N,O-diacetyl-Ser(1)-alpha-MSH

AC-SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-OH BIOTINYL-ACTH (1-13) AMIDE alpha-MSH(4-11)NH2, Ac-Nl4(4)-Orn(5)-Phe(7)-Glu(8)- (D-TRP7,D-LYS8,D-PHE10)-ALPHA-MSH (6-11) AMIDE (NLE4)-ALPHA-MSH,[NLE4]-ALPHA-MSH, AMIDE

AC-SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG-OH Melanotan,alpha-MSH (D-PRO12)-ALPHA-MSH (11-13)

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N-Ac-L-Ser-L-Tyr-L-Ser-L-Met-L-Glu-L-His-L-Phe-L-Arg-L-Trp-Gly-L-Lys-L-Pro-L-Val-NH2 α-Melanotropin【pig】 -Melanocyte-stimulating hormone -Melanotropin, &alpha -MSH α-MSH Acetyl-ACTH (1-13) aMide, α-Melanotropin (huMan) Acetyl-ACTH (1-13) aMide, a-Melanotropin (huMan) Α-MELANOCYTE STIMULATING HORMONE ≥97% Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 acetate salt alpha-Melanotropin (human) Acetate ALFA-MSH alpha-Intermedin C02758 Α-MELANOCYTE STIMULATING HORMONE N-ACETYL-SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-NH2 MELANOCYTE STIMULATING HORMONE MELANOCYTE STIMULATING HORMONE, ALPHA-HUMAN ALPHA-MELANOTROPIN ALPHA-MELANOCYTE STIMULATING HORMONE ALPHA-MELANOCYTE STIMULATING HORMONE, AMIDE ALPHA-MELANOCYTE STIMULATING HORMONE (HUMAN, PORCINE, BOVINE, RAT, MOUSE) ALPHA-MSH ALPHA-MSH, AMIDE ALPHA-MSH (HUMAN, PORCINE, BOVINE, RAT, MOUSE) ALPHA-MSH STIM HORMONE ALPHA-MSN, HUMAN AC-SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-NH2 AC-SYSMEHFRWGKPV-NH2 ACETYL ADRENOCORTICOTROPIC HORMONE (1-13) AMIDE ACETYL-ACTH (1-13) AMIDE ACETYL-SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL NH2 ALPHA-MELANOCYTEN-STIMULIERENDES HORMON* a-MSH AC-SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-NH α-Melanotropin, α-MSH alpha-Melanocyte Stimulating Hormone (human) Ac-L-Ser-L-Tyr-L-Ser-L-Met-L-Glu-L-His-L-Phe-L-Arg-L-Trp-Gly-L-Lys-L-Pro-L-Val-NH2 α-Melanotropin (human) Acetate, α-MSH α-Melanocyte stimulating hormone, ≥97% (HPLC) α-Melanotropin (swine) α-MSH, amide ALPHA-MSH USP/EP/BP α-Melanotropin (human) α-MSH trifluoroacetate salt α-Melanotropin(swine) α-Melanotropin (human) Acetate amide Acetate(581-05-5 free base) a-MSH, amide Acetate(581-05-5 free base) Melanocortin Receptor,hormone,αMSH,inhibit,Inhibitor,α MSH,neuroimmunomodulatory,inflammation,endogenous,MC Receptor,peptide,anti-inflammatory,α-MSH a MSH, amide Acetate(581 05 5 free base),aMSH, amide Acetate(581055 free base) α-Melanotropin Ac-ACTH (1-13) amide alpha-MSH, amide|alpha-Melanocyte Stimulating Hormone α-MSH (CZEN-002) MSH, amide|||CZEN-002|||α-Melanocyte-Stimulating Hormone (MSH), amide (4S,7S,10S,13S,16S,22S)-7-((1H-Imidazol-4-yl)methyl)-16-((1H-indol-3-yl)methyl)-26-amino-22-((S)-2-(((S)-1-amino-3-methyl-1-oxobutan-2-yl)carbamoyl)pyrrolidine-1-carbonyl)-10-benzyl-13-(3-guanidinopropyl)-4-((2S,5S,8S,11S)-8-(4-hydroxybenzyl)-5,11-bis(hydroxymethyl)-2-(2-(methylthio)ethyl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazatetradecanamido)-5,8,11,14,17,20-hexaoxo-6,9,12,15,18,21-hexaazahexacosanoic acid alpha-MSH (alpha-Melanocyte-stimulating hormone), Endogenous melanocortin receptor agonist Mouse melanocyte stimulating hormone elisa kit