ALPHA-MSH
- CAS No.
- 581-05-5
- Chemical Name:
- ALPHA-MSH
- Synonyms
- a-MSH;C02758;ALFA-MSH;ALPHA-MSH;-MSH;α-MSH, amide;α-Melanotropin;alpha-Intermedin;ALPHA-MSH, AMIDE;ALPHA-MSN, HUMAN
- CBNumber:
- CB1440232
- Molecular Formula:
- C77H109N21O19S
- Molecular Weight:
- 1664.88
- MOL File:
- 581-05-5.mol
- Modify Date:
- 2024/7/3 13:03:20
| Density | 1.48±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | 2-8°C |
| solubility | insoluble in EtOH; ≥10.44 mg/mL in H2O with ultrasonic; ≥166.5 mg/mL in DMSO with gentle warming |
| pka | 4.43±0.10(Predicted) |
| form | Lyophilized |
| color | White to off-white |
| Water Solubility | Soluble in water (~1 mg/ml). |
| BRN | 741840 |
ALPHA-MSH price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | M4135 | α-Melanocyte stimulating hormone ≥97% (HPLC) | 581-05-5 | 1MG | ₹12351.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M4135 | α-Melanocyte stimulating hormone ≥97% (HPLC) | 581-05-5 | 5MG | ₹38905.05 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 05-23-0751 | α-Melanocyte-Stimulating Hormone Synthetic α-melanocyte-stimulating hormone. | 581-05-5 | 1MG | ₹8270 | 2022-06-14 | Buy |
ALPHA-MSH Chemical Properties,Uses,Production
Uses
alpha-Melanocyte Stimulating Hormone amide is an endogenous melanocortin receptor agonist (Ki values are 0.12, 31, 660 and 5700 nM for MC1, MC3, MC4 and MC5 receptors respectively). Anti-inflammatory peptide; antagonizes proinflammatory mediators, including TNF-α, IL-6 and NO and induces anti-inflammatory cytokine IL-10. Inhibits food intake and induces penile erections following i.c.v. administration.
General Description
α-Melanocyte-stimulating hormone (α-MSH) is a tridecapeptide, mostly produced by the cells in the brain, pituitary and circulation. Pro-inflammatory cytokines or UV light induced epidermal cells such as keratinocytes and melanocytes synthesize and discharge α–MSH. Poopiomelanocortin (POMC) acts as a precursor for α-Melanocyte-stimulating hormone (α-MSH) production.
Purification Methods
Its solubility in H2O is 1mg/mL. It is separated from the extract by ion-exchange on carboxymethyl cellulose, desalted, evaporated and lyophilised, then chromatographed on Sephadex G-25. [Lande et al. Biochemical Preparations 13 45 1971.]
Structure and conformation
Three types of MSH molecules, with different amino
acid sequences, are contained in the common precursor
POMC in mammals. α-Melanocyte-stimulating hormone
(α-MSH) is composed of 13 aa residues. This peptide is generated from the N-terminal region of the adrenocorticotropic hormone (ACTH), and corresponds to acetylACTH(1–13)-amide. In MSH, the N-terminal Ser residue
is free, monoacetylated at the N position, or diacetylated
at the N and O positions, whereas the carboxyl terminal
is consistently in the amide form. These variations of
MSH are called desacetyl-α-MSH, α-MSH, and diacetyl-α-MSH, respectively. Of these peptides, α-MSH is a classical
α-MSH. β-MSH, which is generated from POMC via
β-lipotropin (β-LPH), is composed of 18 aa residues. Unlike
α-MSH, in β-MSH both termini are free. γ-MSH is produced
from POMC via pro-γ-MSH or N-POMC, which consists of
γ-MSH together with a joining peptide. γ-MSH (also known
as γ1-MSH) is composed of 12 aa residues in which the
N-terminus and the C-terminus are free and amide, respectively. γ3-MSH is composed of 25 aa residues in which the
N-terminal region corresponds to γ1-MSH. Each MSH segment is flanked by basic amino acid residues. Cartilaginous
fish such as sharks, rays, and ratfish possess δ-MSH in addition to the three other MSH peptides. Comparison with the
amino acid sequence and topology of POMC suggests that
δ-MSH might have evolved from β-MSH. Accordingly,
α-MSH and γ-MSH are suggested to share an antecedent.
Teleost POMC lacks γ-MSH.
ALPHA-MSH Preparation Products And Raw materials
Raw materials
Preparation Products
ALPHA-MSH Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | China | 985 | 58 | Inquiry |
| Wuhan Haorong Biotechnology Co.,ltd | +86-18565342920; +8618565342920 | China | 289 | 58 | Inquiry |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | China | 16858 | 58 | Inquiry |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | China | 10312 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| Shanghai Longyu Biotechnology Co., Ltd. | +8613917842738 | China | 2534 | 58 | Inquiry |
| Cellmano Biotech Limited | 0551-65326643 18156095617 | China | 999 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24639 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
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