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Melanotan-1

Melanotan-1 Structure
CAS No.
75921-69-6
Chemical Name:
Melanotan-1
Synonyms
NDP-MSH;CUV1647);Melanotan Ⅰ;MELANOTAN I;Melanotan-1;Melanotropin;Afamelanotide;[Nle4,D-Phe7]α-MSH;MT-I (Melanotan I);(Nle4,D-Phe7)-a-MSH
CBNumber:
CB4252333
Molecular Formula:
C78H111N21O19
Molecular Weight:
1646.85
MOL File:
75921-69-6.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:08
Request For Quotation

Melanotan-1 Properties

Density 1.46±0.1 g/cm3(Predicted)
RTECS OS1830200
storage temp. −20°C
form Solid
pka 4.43±0.10(Predicted)
color White to off-white
Water Solubility Soluble to 0.60 mg/ml in sterile water
Sequence Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
InChIKey UAHFGYDRQSXQEB-LEBBXHLNSA-N
CAS DataBase Reference 75921-69-6(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

WGK Germany  3

Melanotan-1 price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) M8764 [Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt ≥95% (HPLC) 75921-69-6 1MG ₹23035.6 2022-06-14 Buy
Product number Packaging Price Buy
M8764 1MG ₹23035.6 Buy

Melanotan-1 Chemical Properties,Uses,Production

Uses

Melanotan 1 is a highly potent melanotropin with extended biological activity and resistance to enzymatic degredation by serum enzymes. [Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt has been used to detect its effect on O2 consumption and CO2 production in C57BL/6 mice. It is also used to determine its effect on leptin secretion in the primary cultures of differentiated adipocytes.

Origin

Melanotan 1, an alpha MSH analog (Nle4DPhe7-Melanocyte-Stimulating Hormone), is a potent melanocortin developed in the 1980s. Melanotan 2 is a shorter cyclic variant of Melanotan 1 produced in the 1990s. Melanotan 2 was found to increase skin pigmentation at lower cumulative doses than Melanotan 1. However, in clinical trials it was found to have more side effects including nausea somnolence and penile erections[1].

References

[1] Robert T Dorr. “Effects of a superpotent melanotropic peptide in combination with solar UV radiation on tanning of the skin in human volunteers.” Archives of dermatology 140 7 (2004): 827–35.

General Description

[Nle4, D-Phe7]-α-melanocyte stimulating hormone is a potent analogue of α;-melanocyte-stimulating hormone (α -MSH). αMSH is a tridecapeptide, mostly produced by the cells in the brain, pituitary and in circulation.

Biochem/physiol Actions

[Nle4, D-Phe7]-α-melanocyte stimulating hormone is 100 times more potent than α-MSH in stimulating melanoma tyrosinase, which is a rate limiting enzyme in melanin biosynthesis and is 26 times as potent as α-MSH in S91adenylate cyclase assay. α –MSH has an essential role to play in melanin production in animals. It also regulates development of several skin diseases, including cutaneous inflammation and hyper-proliferative skin diseases.

Side effects

The TGA has previously warned consumers against the use of Melanotan-I and Melanotan-II for tanning and weight loss. Side-effects include darkened skin, increased moles and freckles, nausea, vomiting, loss of appetite, flushing of the face, involuntary stretching and yawning, and spontaneous erections.

Melanotan-1 Preparation Products And Raw materials

Raw materials

Preparation Products

Melanotan-1 Suppliers

Global( 247)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
ZHEJIANG JIUZHOU CHEM CO., LTD +86-0576225566889 +86-13454675544 China 19947 58 Inquiry
Hebei Xinsheng New Material Technology Co., LTD. +86-16632316109 China 1092 58 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
zhuzhou dingcheng meihei comestic co.,ltd +8618873369619 China 260 58 Inquiry
Hebei Xunou new energy Technology Co., LTD +undefined17531957005 China 36 58 Inquiry
Strong peptide cross-border e-commerce Co. LTD +undefined13930052870 China 84 58 Inquiry
Shanghai Affida new material science and technology center +undefined15081010295 China 114 58 Inquiry
Dorne Chemical Technology co. LTD +86-86-13583358881 +8618560316533 China 3148 58 Inquiry
Shanghai Yunao International Trade Co., Ltd +8617621705551 China 265 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
ZHEJIANG JIUZHOU CHEM CO., LTD 58
Hebei Xinsheng New Material Technology Co., LTD. 58
BOC Sciences 58
zhuzhou dingcheng meihei comestic co.,ltd 58
Hebei Xunou new energy Technology Co., LTD 58
Strong peptide cross-border e-commerce Co. LTD 58
Shanghai Affida new material science and technology center 58
Dorne Chemical Technology co. LTD 58
Shanghai Yunao International Trade Co., Ltd 58

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75921-69-6(Melanotan-1 )Related Search:

D-Phenylalanine Diethylstilbestrol Melanotan Ⅱ Actate,MelanotanⅡAcetate,Melanotan-II(MT-II),Melanotan II acetate salt,Mt-Ii(Melanotan),Melanotan 2,Melanotan Ц,MELANOTAN II ALPHA-MSH Melanotan II）,MT-I (a MSH)
ALPHA-MSH Melanotan,alpha-MSH Melanotan II acetate AC-LYS-PRO-VAL-NH2 MELANOTAN II, MT-Ⅱ
Melanotan 1 [Nle4, D-Phe7]alfa-MSH, Melanotan I MELANOTAN II TRIFLUOROACETATE SALT Melanotan Ⅱ MelanotanⅠ(α-MSH)
Melanotan I acetate AC-SYS(NLE)EH(D-PHE)RWGKPVK(BIOTIN)-AMIDE
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[NLE4,D-PHE]ALPHA-MELANOCYTE STIMULATING HORMONE (NLE4,D-PHE7)-ALPHA-MSH [Nle4,D-Phe7]α-MSH Ac-L-Ser-L-Tyr-L-Ser-L-Nle-L-Glu-L-His-D-Phe-L-Arg-L-Trp-Gly-L-Lys-L-Pro-L-Val-NH2 N-Ac-L-Ser-L-Tyr-L-Ser-L-Nle-L-Glu-L-His-D-Phe-L-Arg-L-Trp-Gly-L-Lys-L-Pro-L-Val-NH2 [Nle4,DPhe7] a-MSH, amide [Nle4,DPhe7] a-MSH, amide:Melanotan Ⅰ [Nle4, D-Phe7]-α-MSH, amide [Nle4]-α-MSH, amide (Nle4,D-Phe7)-α-MSH AfaMelanotide, NDP-MSH, Melanotan 1, CUV1647 (Nle4,D-Phe7)-a-MSH AfaMelanotide, NDP-MSH, Melanotan 1, CUV1647 NLE4, D-PHE7 .ALPHA.-MSH, NDP-MSH, MELANOTAN I Melanotan Ⅰ Acetate [Nle4, D-Phe7] α-MSH NDP-MSH Melanotan Ⅰ [Nle4,D-Phe7] α -MSH NDP-MSH Melanotan I alpha-melanotropin, [Nle3,D-Phe7], trifluoroacetate Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 acetate salt a-Melanotropin (swine),4-L-norleucine-7-D-phenylalanine- Afamelanotide acetate [NLE4, D-PHE7]-ALPHA-MSH, AMIDE [NLE4,D-PHE7]-ALPHA-MELANOCYTE-STIMULATING HORMONE [NLE4,DPHE7] ALPHA-MELANOCYTE STIMULATING HORMONE, AMIDE NDP-MSHAC-SER-TYR-SER-NLE-GLU-HIS-D-PHE-ARG-TRP-GLY-LYS-PRO-VAL-NH2 NDP-MSH Melanotan ① Acetate [NLE4, DPHE7] A-MSH, AMIDE; MELANOTAN Ⅰ Melanotan Ⅰ MELANOTAN I AC-SYS-NLE-EHFRWGKPV-NH2 AC-SER-TYR-SER-NLE-GLU-HIS-D-PHE-ARG-TRP-GLY-LYS-PRO-VAL-NH2 NLE-4-D-PHE-7-A-MELANOCYTE*STIMULATING H ORMONE [Nle4,D-Phe7]-MSHNDP-MSH [Nle4,D-Phe7] a-Melanocyte stimulating hormone,amide [nle4, d-phe7]-α-melanocyte stimulating hormone trifluoroacetate salt MSH, 4-Nle-7-Phe-alpha- Melanotan I Acetate MelanotanⅠ(α-MSH) 4-Nle-7-phe-alpha-msh 4-Norleucyl-7-phenylalanine-alpha-msh Melanotan-1 Melanotropin Melanotan II(10mg) /Mt-2 for Tanning Melanotan 2 CAS NO.75921-69-6 CAS NO.75921-69-6 Afamelanotide [Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone (MSH), amide [Nle4, D-Phe7]-α-Melanocyte stimulating hormone trifluoroacetate salt, ≥95% (HPLC) N-Acetyl-L-seryl-L-tyrosyl-L-seryl-L-norleucyl-L-a-glutamyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valinamide α-Melanotropin (swine), 4-L-norleucine-7-D-phenylalanine- Melanotan-1 USP/EP/BP 4-L-norleucine-7-D-phenylalanine-α-Melanotropin (Nle4,D-Phe7)-α-MSH Melanotan 1 (MT1) acetate MT I （Melanotan-1） MT-I (Melanotan I) Melanotan I (MT1) acetate [Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt Melanotan I (Afamelanotide CUV1647) α-Melanotropin (swine), 4-L-norleucine-7-D-phenylalanine-