Melanotan II

Melanotan II Properties

Density	1.43
RTECS	OL4225000
storage temp.	Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility	H₂O: 5 mg/mL, soluble
form	solid
pka	13.00±0.70(Predicted)
color	white
Water Solubility	Soluble to 0.70 mg/ml in water
InChIKey	JDKLPDJLXHXHNV-MFVUMRCOSA-N
CAS DataBase Reference	121062-08-6(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P280-P302+P352-P362+P364
Hazard Codes	Xn
Risk Statements	22
WGK Germany	3
HS Code	3504009000

Melanotan II price More Price(1)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	M8693	Melanotan II acetate salt ≥95% (HPLC)	121062-08-6	1MG	₹20708.23	2022-06-14	Buy

Product number	Packaging	Price	Buy
M8693	1MG	₹20708.23	Buy

Melanotan II Chemical Properties,Uses,Production

Uses

Melanotan II acetate salt has been used to study its inhibitory effects on feeding and energy expenditure in rats. It is a lab-made chemical that is similar to a hormone found in people. Melanotan II has been shown to have melanogenesis (tanning) and aphrodisiac effects on humans.

Biochem/physiol Actions

Melanotan II is a MC3-R/MC4-R melanocortin agonist. It is a high affinity melanocortin receptor agonist (Ki values are 0.67, 6.6, 34 and 46 nM for MC1, MC4, MC3 and MC5 receptors respectively). Stimulates erectile activity, inhibits food intake and displays neuroprotective properties in vivo.

Clinical Use

Melanotan II has been a new treatment for rosacea discussed in the various rosacea support groups on the internet.
Melanotan I and Melanotan II are both analogs of the peptide hormone alpha-melanocyte stimulating hormone (a-MSH) that tend to induce skin tanning. Melanotan II has the additional effect of increasing libido.
Melanotan II is an α-MSH analog which underwent clinical trials for the treatment of erectile dysfunction. Preliminary double-blind, placebo-controlled studies demonstrated the efficacy of melanotan in inducing penile erection in men with erectile dysfunction, although in a very restricted population.Unfortunately, there are no experimental data on the mode of action of melanotan II, as melanotan II is the first α-MSH agonist inducing penile erection when injected peripherally.
Illustration of the proerectile effect of melanotan II (MT-II) in humans. Placebo (A) or MT-II (B, 25 ug/kg and C, 133 ug/kg) was injected subcutaneously in patients and RigiScan recording was performed from 6 h. Apparent erections developed in 8 of 10 men treated with MT-II. (Reproduced with permission from Wessells H et al. Effect of an alphamelanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction. Urology 2000; 56:641–646.)

Side effects

When given as a shot: Melanotan is POSSIBLY UNSAFE when given as a shot. It can causes nausea, stomachcramps, decreased appetite, flushing, tiredness, yawning, darkened skin, spontaneous erections of the penis, and other side effects. In some people, especially those with light skin, a change in the shape of moles, new moles, and skin cancer, have all occurred in people using melanotan.

References

[1] SOPHIA HATZIIEREMIA. A liquid chromatographic/tandem mass spectroscopic method for quantification of the cyclic peptide melanotan-II. Plasma and brain tissue concentrations following administration in mice[J]. Rapid Communications in Mass Spectrometry, 2007. DOI:10.1002/rcm.3106.
[2] WEKWEJTPATRYK KirykAnna WojdaUrszula. Melanotan-II reverses memory impairment induced by a short-term HF diet.[J]. Biomedicine & Pharmacotherapy, 2023. DOI:10.1016/j.biopha.2023.115129.
[3] HJULER K F, LORENTZEN H F. Melanoma Associated with the Use of Melanotan-II[J]. Dermatology, 2013, 228: 34-36. DOI:10.1159/000356389.
[4] DORR R T, LINES R, LEVINE N, et al. Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study.[J]. Life sciences, 1996, 58 20: 1777-1784. DOI:10.1016/0024-3205(96)00160-9.

Melanotan II Preparation Products And Raw materials

Raw materials

L-Lysinamide, N-acetyl-L-norleucyl-L-α-aspartyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-

Preparation Products

Melanotan II Suppliers

Global( 397)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Manus Aktteva	+91 (79) 6512-3395	New Delhi, India	581	34	Inquiry
Ronak Alkalies And Chemicals Private Limited	08048372180Ext 358	Gujarat, India	11	58	Inquiry
Aliya Aquarium	08600290020	Maharashtra, India	3	58	Inquiry
Hebei Weimiao Import and Export Trade Co., Ltd.	+undefined19948166995	China	73	58	Inquiry
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	China	21676	55	Inquiry
Shanghai Longyu Biotechnology Co., Ltd.	+8613917842738	China	2534	58	Inquiry
Changzhou Xuanming Pharmaceutical Technology Co., Ltd.	+8618068519287	China	833	58	Inquiry
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	China	10522	58	Inquiry
ZhenYiBio Technology Inc	+8615309206328	China	298	58	Inquiry
Wuhan Cell Pharmaceutical Co., Ltd	+86-13129979210 +86-13129979210	China	376	58	Inquiry

Supplier	Advantage
Manus Aktteva	34
Ronak Alkalies And Chemicals Private Limited	58
Aliya Aquarium	58
Hebei Weimiao Import and Export Trade Co., Ltd.	58
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Longyu Biotechnology Co., Ltd.	58
Changzhou Xuanming Pharmaceutical Technology Co., Ltd.	58
Zhejiang J&C Biological Technology Co.,Limited	58
ZhenYiBio Technology Inc	58
Wuhan Cell Pharmaceutical Co., Ltd	58

121062-08-6(Melanotan II)Related Search:

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Acetyl-(Nle4,Asp5,D-Phe7,Lys10)-cyclo-α-MSH (4-10) aMide Melanotan II, MTII, BreMelanotide aMide AC-NLE-CYCLO(-BETA-ASP-HIS-D-PHE-ARG-TRP-EPSILON-LYS-NH2) AC-NLE-CYCLO(-ASP-HIS-D-PHE-ARG-TRP-LYS-NH2) ACETATE SALT AC-NLE4-C[ASP5, D-PHE7, LYS10]ALPHA-MSH (4-10)-NH2 AC-[NLE4, ASP5, D-PHE7, LYS10]-ALPHA-MSH (4-10)-NH2 (AC-NLE4, ASP5, DPHE7, LYS10)-CYCLO-ALPHA-MSH (4-10) AMIDE AC-NLE-ASP-HIS-D-PHE-ARG-TRP-LYS-NH2 (1S,4S,7S,10R,13S,16S)-16-[[(2S)-2-acetamidohexanoyl]amino]-10-(benzyl)-7-(3-guanidinopropyl)-13-(1H-imidazol-5-ylmethyl)-4-(1H-indol-3-ylmethyl)-3,6,9,12,15,18-hexaketo-2,5,8,11,14,19-hexazacyclotricosane-1-carboxamide (1S,4S,7S,10R,13S,16S)-16-[[(2S)-2-acetamidohexanoyl]amino]-7-[3-(diaminomethylideneamino)propyl]-13-(1H-imidazol-5-ylmethyl)-4-(1H-indol-3-ylmethyl)-3,6,9,12,15,18-hexaoxo-10-(phenylmethyl)-2,5,8,11,14,19-hexazacyclotricosane-1-carboxamide (1S,4S,7S,10R,13S,16S)-16-[[(2S)-2-acetamidohexanoyl]amino]-7-[3-[bis(azanyl)methylideneamino]propyl]-13-(1H-imidazol-5-ylmethyl)-4-(1H-indol-3-ylmethyl)-3,6,9,12,15,18-hexaoxo-10-(phenylmethyl)-2,5,8,11,14,19-hexazacyclotricosane-1-carboxamide Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-NH2 (AMide bond Asp5-Lys10) Acetyl-(Nle4,Asp5,D-Phe7,Lys10)-cyclo-a-MSH (4-10) aMide Melanotan II, MTII, BreMelanotide aMide Melanotan ② Malanotan II Acetate Melanotan II SynonyMs Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-NH2 melanotan,Melanotan II Anti-MTNR1B (C-terminal) antibody produced in goat melatonin receptor 1B melatonin receptor MEL1B Anti-MTNR1B (AB2) antibody produced in rabbit Anti-MTNR1B (AB1) antibody produced in rabbit mt2 melatonin receptor mt2 receptor Acetyl-(Nle4,Asp5,D-Phe7,Lys10)-cyclo-α-MSH (4-10) amide, Melanotan II [N-ACETYL-NLE4,ASP5,D-PHE7,LYS10]-ALPHA-MSH (4-10) AMIDE ASP5-LYS10, CYCLIC LACTAM MTII Ac-[Nle⁴Asp⁵D-Phe⁷Lys¹⁰]α-MSH-(4-10)-NH₂ Melanotan Ц MalanotanIi Mt-Ii(Melanotan) MelanotanAcetate Melanotan-II(MT-II) Ac-Nle-cyclo(Asp-His-D-Phe-Arg-Trp-Lys)-NH2 N-Acetyl-L-norleucyl-L-alpha-aspartyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-L-lysinamide (2->7)-lactam Melanotan Ⅱ Actate MelanotanⅡAcetate (Ac-Nle4,Asp5,D-Phe7,Lys10)-cyclo-a-MSH (4-10) amide Ac-[Nle4Asp5D-Phe7Lys10]α-MSH-(4-10)-NH2 Melanotan II acetate salt Muscarinic Toxin-2 from Dendroaspis angusticeps venom Ac-Nle4, Asp5, DPhe7, Lys10-Cyclo-a-MSH: 4-10 amide, MTII Melanotan-II Ac-Nle-cyclo(-Asp-His-D-Phe-Arg-Trp-Lys-NH2) AC-NLE-ASP-HIS-D-PHE-ARG-TRP-LYS-NH2, ASP5-LYS10, CYCLIC LACTAM AC-NLE-C[+ASP-HIS-DPHE-ARG-TRP-LYS]-NH2 [ACETYL-NLE4, ASP5, D-PHE7, LYS10]-ALPHA-MELANOCYTE STIMULATING HORMONE (4-10) AMIDE [ACETYL-NLE4, ASP5, D-PHE7, LYS10]-ALPHA-MSH (4-10) AMIDE (ACETYL-NLE4,ASP5,D-PHE7,LYS10)-CYCLO-ALPHA-MSH (4-10) AMIDE ACETATE SALT MELANOTAN II M.W. 1024.19 C50H69N15O9 Melanotan II Acetate(MT-II) MT2/Melanotan-II Melanotan II acetate salt, ≥95% (HPLC) EGF Serum Epidermal Growth Factor AFGF Powder warehouse MT2 Melanotan II (MT-II) Acetate L-Lysinamide, N-acetyl-L-norleucyl-L-α-aspartyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-, (2→7)-lactam Melanotan-II/MT2