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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Cytoskeletal Signaling >Microtubule Associated inhibitors >N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamidehydrochloride

N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamidehydrochloride

N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamidehydrochloride Structure
CAS No.
313553-47-8
Chemical Name:
N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamidehydrochloride
Synonyms
INH1;CS-1011;IBT 13131;INH1 (IBT13131);Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1;N-(4-(2,4-Dimethylphenyl)thiazol-2-yl)benzamide;N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]-benzamide;Benzamide, N-[4-(2,4-dimethylphenyl)-2-thiazolyl]-;N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamidehydrochloride;N-(4-(2,4-diMethylphenyl)thiazol-2-yl)benzaMide hydrochloride
CBNumber:
CB12518874
Molecular Formula:
C18H16N2OS
Molecular Weight:
308.4
MOL File:
313553-47-8.mol
Modify Date:
2024/7/2 8:55:00
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N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamidehydrochloride Properties

Density 1.239±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. Sealed in dry,2-8°C
solubility ≥30.8 mg/mL in DMSO; insoluble in H2O; ≥12 mg/mL in EtOH
form solid
color White to off-white
CAS DataBase Reference 313553-47-8

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamidehydrochloride price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 373270 Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1 - CAS 313553-47-8 - Calbiochem The Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1, also referenced under CAS 313553-47-8, controls the biological activity of Hec1/Nek2 Mitotic Pathway. 313553-47-8 10MG ₹53890 2022-06-14 Buy
Product number Packaging Price Buy
373270 10MG ₹53890 Buy

N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamidehydrochloride Chemical Properties,Uses,Production

General Description

A cell-permeable thiazolyl benzamide compound that directly binds Hec1 and disrupts Hec1/Nek2 complex formation, resulting in defective Hec1 kinetochores localization and cellular Nek2 destabilization/downregulation. Shown to induce a transient mitotic arrest in HeLa cultures and inhibit the proliferation of 10 breast cancer cell lines (GI50 of 10-21 μM) as well as the cervical HeLa and colon HCT116 cancer lines, while exhibiting reduced potency against the noncancerous MCF10A line (GI50 = 41 μM). Reported to suppress the MDA-MB-468-derived tumor growth (by ~53% and ~75% 3 wks after a 7-wk treatment period with 50 mg/kg and 100 mg/kg INH1, repectively, i.p.) in a murine breast cancer model in vivo.

N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamidehydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamidehydrochloride Suppliers

Global( 105)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
SHANGHAI T&W PHARMACEUTICAL CO., LTD. +86-021-61551413 +8618813727289 China 5738 58 Inquiry
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Supplier Advantage
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
ATK CHEMICAL COMPANY LIMITED 60
BOC Sciences 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd 58
TargetMol Chemicals Inc. 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58

N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamidehydrochloride Spectrum

N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamidehydrochloride(313553-47-8)1HNMR

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N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamidehydrochloride IBT 13131 N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]-benzamide N-(4-(2,4-diMethylphenyl)thiazol-2-yl)benzaMide hydrochloride N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]-benzamide INH1 INH1 (IBT13131) N-[4-(2,4-dimethylphenyl)-1,3-thiazol-2-yl]benzamide,hydrochloride CS-1011 Benzamide, N-[4-(2,4-dimethylphenyl)-2-thiazolyl]- N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamidehydrochloride USP/EP/BP INH1 N-(4-(2,4-Dimethylphenyl)thiazol-2-yl)benzamide Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1 313553-47-8 C18H16N2OSHCl Inhibitors