Trifluoperazine dihydrochloride
- CAS No.
- 440-17-5
- Chemical Name:
- Trifluoperazine dihydrochloride
- Synonyms
- Urinox;skf5019;Stelazin;eskazine;STELAZINE;Eskazinyl;Ai3-50137;Calmazine;tryptazine;Einecs 207-123-0
- CBNumber:
- CB1274387
- Molecular Formula:
- C21H26Cl2F3N3S
- Molecular Weight:
- 480.42
- MOL File:
- 440-17-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/26 15:15:06
| Melting point | 243 °C (dec.)(lit.) |
|---|---|
| Flash point | 9℃ |
| storage temp. | -20°C |
| solubility | ethanol: soluble5mg/mL |
| pka | pK1 3.9, pK2 8.1(at 25℃) |
| form | powder |
| color | white to off-white |
| λmax | 312nm(MeOH)(lit.) |
| Merck | 14,9680 |
| BRN | 3820024 |
| Stability | Hygroscopic |
| CAS DataBase Reference | 440-17-5(CAS DataBase Reference) |
| EPA Substance Registry System | 10H-Phenothiazine, 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-, dihydrochloride (440-17-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H319-H336-H341-H372-H410 | |||||||||
| Precautionary statements | P201-P273-P301+P312+P330-P305+P351+P338-P308+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 36 | |||||||||
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | SP1750000 | |||||||||
| F | 3-10 | |||||||||
| HS Code | 29343000 | |||||||||
| NFPA 704 |
|
Trifluoperazine dihydrochloride price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | T8516 | Trifluoperazine dihydrochloride ≥99%, powder | 440-17-5 | 5G | ₹9222.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T8516 | Trifluoperazine dihydrochloride ≥99%, powder | 440-17-5 | 10G | ₹16421.53 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T6062 | Trifluoperazine hydrochloride meets USP testing specifications | 440-17-5 | 5G | ₹7274.4 | 2022-06-14 | Buy |
| TCI Chemicals (India) | T2849 | Trifluoperazine Dihydrochloride | 440-17-5 | 5G | ₹6800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | T2849 | Trifluoperazine Dihydrochloride | 440-17-5 | 25G | ₹11300 | 2022-05-26 | Buy |
Trifluoperazine dihydrochloride Chemical Properties,Uses,Production
Description
Trifluoperazine (TFP) is a phenothiazine compound with anti-
Chemical Properties
Cream Fine Powder
Uses
Trifluoperazine dihydrochloride has been used as a calmodulin kinase antagonist in cultured Aplysia californica neurons. Trifluoperazine dihydrochloride has also been used as a PMCA inhibitor in mouse duodenal tissues to block the transcellular active calcium flux.
General Description
Trifluoperazinehydrochloride, 10-[3-(4-Methyl-1-piperazinyl)propyl-[2-(trifluoromethyl)phenothiazine dihydrochloride (Stelazine).The absorption of trifluoperazine is erratic and variable andit is widely distributed into tissues. The excretion of trifluoperazineoccurs 50% via kidneys and the other 50% isthrough enterohepatic circulation. The metabolism and druginteractions of trifluoperazine are the same as with the otherphenothiazines. Trifluoperazine does not show any specificdrug interactions. Trifluoperazine is indicated for the managementof schizophrenia and short-term treatment ofnonpsychotic anxiety.
Safety Profile
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of F-, NOx, SOx, and HCl. See also FLUORIDES.
Purification Methods
Recrystallise the salt from absolute EtOH, filter the crystals, dry them in vacuo and store them in tightly stoppered bottles because it is hygroscopic. It is soluble in H2O but insoluble in *C6H6, Et2O and alkaline aqueous solution. It has UV at 258 and 307.5nm (log 4.50 and 3.50) in EtOH (neutral species). [Craig max et al. J Org Chem 22 709 1957.] It is a calmodulin inhibitor [Levene & Weiss J Parmacol Exptl Ther 208 454 1978] and is a psychotropic agent [Fowler Arzneim.-Forsch 27 866 1977]. [Beilstein 27 III/IV 1353.]
Trifluoperazine dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Trifluoperazine dihydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Anphar Laboratories Pvt Ltd | +91-9018670066 +91-9018670066 | Himachal Pradesh, India | 17 | 58 | Inquiry |
| VAIKUNTH CHEMICAL PVT. LTD. | +91-9978441444 +264-9824111879 | Gujarat, India | 17 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Om Pharmaceutical Industries | 08066085835Ext 129 | Mumbai, India | 24 | 58 | Inquiry |
| Pellucid Pharma | 08048371509Ext 991 | Ahmedabad, India | 23 | 58 | Inquiry |
| Triveni Interchem Private Limited (Group Of Triveni... | 08046042087 | Gujarat, India | 497 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
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