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ChemicalBook > Product Catalogue >API >Nervous system drugs >Antipsychotics >Trifluoperazine dihydrochloride

Trifluoperazine dihydrochloride

Trifluoperazine dihydrochloride Structure
  • ₹6800 - ₹16421.53
  • Product name: Trifluoperazine dihydrochloride
  • CAS: 440-17-5
  • MF: C21H26Cl2F3N3S
  • MW: 480.42
  • EINECS:207-123-0
  • MDL Number:MFCD00012656
  • Synonyms:LABOTEST-BB LT00452002;10-[3-(4-METHYL-1-PIPERAZINYL)PROPYL]-2-TRIFLUOROMETHYL-PHENOTHIAZINE DIHYDROCHLORIDE;10-[3-(4-METHYLPIPERAZIN-1-YL)PROPYL]-2-(TRIFLUOROMETHYL)-10H-PHENOTHIAZINE DIHYDROCHLORIDE;TRIFLUOPERAZINE 2HCL;TRIFLUOPERAZINE DIHYDROCHLORIDE;TRIFLUOPERAZINE HCL;TRIFLUOPERAZINE HYDROCHLORIDE;STELAZINE
5 prices
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Brand

  • Sigma-Aldrich(India)
  • TCI Chemicals (India)

Package

  • 5G
  • 10G
  • 25G
  • ManufacturerSigma-Aldrich(India)
  • Product numberT8516
  • Product descriptionTrifluoperazine dihydrochloride ≥99%, powder
  • Packaging10G
  • Price₹16421.53
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT8516
  • Product descriptionTrifluoperazine dihydrochloride ≥99%, powder
  • Packaging5G
  • Price₹9222.9
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT6062
  • Product descriptionTrifluoperazine hydrochloride meets USP testing specifications
  • Packaging5G
  • Price₹7274.4
  • Updated2022-06-14
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberT2849
  • Product descriptionTrifluoperazine Dihydrochloride
  • Packaging25G
  • Price₹11300
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberT2849
  • Product descriptionTrifluoperazine Dihydrochloride
  • Packaging5G
  • Price₹6800
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) T8516 Trifluoperazine dihydrochloride ≥99%, powder 10G ₹16421.53 2022-06-14 Buy
Sigma-Aldrich(India) T8516 Trifluoperazine dihydrochloride ≥99%, powder 5G ₹9222.9 2022-06-14 Buy
Sigma-Aldrich(India) T6062 Trifluoperazine hydrochloride meets USP testing specifications 5G ₹7274.4 2022-06-14 Buy
TCI Chemicals (India) T2849 Trifluoperazine Dihydrochloride 25G ₹11300 2022-05-26 Buy
TCI Chemicals (India) T2849 Trifluoperazine Dihydrochloride 5G ₹6800 2022-05-26 Buy

Properties

Melting point :243 °C (dec.)(lit.)
Flash point :9℃
storage temp. :-20°C
solubility :ethanol: soluble5mg/mL
pka :pK1 3.9, pK2 8.1(at 25℃)
form :powder
color :white to off-white
λmax :312nm(MeOH)(lit.)
Merck :14,9680
BRN :3820024
Stability :Hygroscopic
CAS DataBase Reference :440-17-5(CAS DataBase Reference)
EPA Substance Registry System :10H-Phenothiazine, 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-, dihydrochloride (440-17-5)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H336 May cause drowsiness or dizziness Specific target organ toxicity,single exposure; Narcotic effects Category 3 Warning P261, P271, P304+P340, P312,P403+P233, P405, P501
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P314, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P201 Obtain special instructions before use.
P273 Avoid release to the environment.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Trifluoperazine (TFP) is a phenothiazine compound with anti-adrenergic and anti-dopaminergic actions typical of antipsychotic agents. It antagonizes adrenergic receptors, with selectivity for α1 over the α2 subtypes (Kis = 24, 653, 163, and 391 nM for α1A, α2A, α2B, and α2C, respectively). TFP binds with much higher affinity to the dopamine D2-like receptor (Kd = 0.96 nM) compared to the dopamine D4-like and the serotonin 5-HT2A receptors (Kds = 44 and 135 nM, respectively). Furthermore, TFP antagonizes calmodulin (CaM) and alters the calcium-binding properties of calsequestrin (CSQ). TFP has been shown to activate type-2 ryanodine receptors independently of its CaM and CSQ activity.

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