Trifluoperazine dihydrochloride
- ₹6800 - ₹16421.53
- Product name: Trifluoperazine dihydrochloride
- CAS: 440-17-5
- MF: C21H26Cl2F3N3S
- MW: 480.42
- EINECS:207-123-0
- MDL Number:MFCD00012656
- Synonyms:LABOTEST-BB LT00452002;10-[3-(4-METHYL-1-PIPERAZINYL)PROPYL]-2-TRIFLUOROMETHYL-PHENOTHIAZINE DIHYDROCHLORIDE;10-[3-(4-METHYLPIPERAZIN-1-YL)PROPYL]-2-(TRIFLUOROMETHYL)-10H-PHENOTHIAZINE DIHYDROCHLORIDE;TRIFLUOPERAZINE 2HCL;TRIFLUOPERAZINE DIHYDROCHLORIDE;TRIFLUOPERAZINE HCL;TRIFLUOPERAZINE HYDROCHLORIDE;STELAZINE
5 prices
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Brand
- Sigma-Aldrich(India)
- TCI Chemicals (India)
Package
- 5G
- 10G
- 25G
- ManufacturerSigma-Aldrich(India)
- Product numberT8516
- Product descriptionTrifluoperazine dihydrochloride ≥99%, powder
- Packaging10G
- Price₹16421.53
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberT8516
- Product descriptionTrifluoperazine dihydrochloride ≥99%, powder
- Packaging5G
- Price₹9222.9
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberT6062
- Product descriptionTrifluoperazine hydrochloride meets USP testing specifications
- Packaging5G
- Price₹7274.4
- Updated2022-06-14
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberT2849
- Product descriptionTrifluoperazine Dihydrochloride
- Packaging25G
- Price₹11300
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberT2849
- Product descriptionTrifluoperazine Dihydrochloride
- Packaging5G
- Price₹6800
- Updated2022-05-26
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | T8516 | Trifluoperazine dihydrochloride ≥99%, powder | 10G | ₹16421.53 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | T8516 | Trifluoperazine dihydrochloride ≥99%, powder | 5G | ₹9222.9 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | T6062 | Trifluoperazine hydrochloride meets USP testing specifications | 5G | ₹7274.4 | 2022-06-14 | Buy |
TCI Chemicals (India) | T2849 | Trifluoperazine Dihydrochloride | 25G | ₹11300 | 2022-05-26 | Buy |
TCI Chemicals (India) | T2849 | Trifluoperazine Dihydrochloride | 5G | ₹6800 | 2022-05-26 | Buy |
Properties
Melting point :243 °C (dec.)(lit.)
Flash point :9℃
storage temp. :-20°C
solubility :ethanol: soluble5mg/mL
pka :pK1 3.9, pK2 8.1(at 25℃)
form :powder
color :white to off-white
λmax :312nm(MeOH)(lit.)
Merck :14,9680
BRN :3820024
Stability :Hygroscopic
CAS DataBase Reference :440-17-5(CAS DataBase Reference)
EPA Substance Registry System :10H-Phenothiazine, 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-, dihydrochloride (440-17-5)
Flash point :9℃
storage temp. :-20°C
solubility :ethanol: soluble5mg/mL
pka :pK1 3.9, pK2 8.1(at 25℃)
form :powder
color :white to off-white
λmax :312nm(MeOH)(lit.)
Merck :14,9680
BRN :3820024
Stability :Hygroscopic
CAS DataBase Reference :440-17-5(CAS DataBase Reference)
EPA Substance Registry System :10H-Phenothiazine, 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-, dihydrochloride (440-17-5)
Safety Information
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Description
Trifluoperazine (TFP) is a phenothiazine compound with anti-adrenergic and anti-dopaminergic actions typical of antipsychotic agents. It antagonizes adrenergic receptors, with selectivity for α1 over the α2 subtypes (Kis = 24, 653, 163, and 391 nM for α1A, α2A, α2B, and α2C, respectively). TFP binds with much higher affinity to the dopamine D2-like receptor (Kd = 0.96 nM) compared to the dopamine D4-like and the serotonin 5-HT2A receptors (Kds = 44 and 135 nM, respectively). Furthermore, TFP antagonizes calmodulin (CaM) and alters the calcium-binding properties of calsequestrin (CSQ). TFP has been shown to activate type-2 ryanodine receptors independently of its CaM and CSQ activity.More related product prices
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