DELAVIRDINE, MESYLATE
- CAS No.
- 147221-93-0
- Chemical Name:
- DELAVIRDINE, MESYLATE
- Synonyms
- C08087;U-90152S;U 90152 (mesylate);elavirdinemesylate;Delavirdine Mesylat;Delavirdine mesilate;BHAP-U 90152 (mesylate);Delavirdine methane sulfonate;DELAVIRDINE (MESYLATE);U 90152;DELAVIRDINE MESYLATE (U 90152 MESYLATE)
- CBNumber:
- CB1292152
- Molecular Formula:
- C23H32N6O6S2
- Molecular Weight:
- 552.67
- MOL File:
- 147221-93-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/9/28 17:55:30
| Melting point | 118-120°C |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO: >5mg/mL |
| form | powder |
| color | white to tan |
| CAS DataBase Reference | 147221-93-0 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H361 | |||||||||
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501-P264-P280-P305+P351+P338-P337+P313P | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
DELAVIRDINE, MESYLATE price More Price(2)
DELAVIRDINE, MESYLATE Chemical Properties,Uses,Production
Description
Rescriptor was launched in the US for HIV positive individuals. It can be prepared in seven steps from 2-chloro-3-nitropyridine and piperazine. Rescriptor is a member of the bis(heteroaryl)piperazine (BHAP) class of non-nucleoside HIV-1 reverse transcriptase inhibitors (NNRTIs) of which it is a second generation drug. It acts exclusively as an allosteric mixed inhibitor of both RNA- and DNA-directed polymerase domains of RT and has a much higher binding affintiy for the enzymesubstrate complex than for the free enzyme. Rescriptor does not inhibit RNase H activity of RT. It prevented the spread of HIV significantly longer than AZT. Development of resistance to Rescriptor can occur, however the mutated strain becomes more vulnerable to other members of the NNRTIs. It is metabolized in the liver by CYP3A.
Chemical Properties
Light Brown Solid
Definition
ChEBI: The monomethanesulfonic acid salt of delavirdine, a non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. Viral resistance emerges rapidly when delavirdine is used alone, so it is therefore used (as the methanesulfonic acid salt) with other antiretrovirals for combination therapy of HIV infection.
DELAVIRDINE, MESYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Medilink Pharmachem | +91 (79) 3007-0133 | New Delhi, India | 424 | 50 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12460 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | China | 52861 | 58 | Inquiry |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | China | 19994 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | China | 25363 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Medilink Pharmachem | 50 |
| CLEARSYNTH LABS LTD. | 58 |
| Hebei Mojin Biotechnology Co., Ltd | 58 |
| ATK CHEMICAL COMPANY LIMITED | 60 |
| BOC Sciences | 58 |
| career henan chemical co | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 58 |
| Labnetwork lnc. | 58 |
| InvivoChem | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 58 |