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N-(Hydroxymethyl)phthalimide

N-(Hydroxymethyl)phthalimide Structure
CAS No.
118-29-6
Chemical Name:
N-(Hydroxymethyl)phthalimide
Synonyms
AURORA KA-454;N-(HydroxymethyL;AKOS BBS-00004724;IFLAB-BB F0777-0575;PHTHALIMIDOMETHANOL;N-(Hydroxymethyl)ph;oxymethylphthalimide;Phthalimidylmethanol;N-Methylolphthalimide;Oxymethyl phthalimide
CBNumber:
CB1392676
Molecular Formula:
C9H7NO3
Molecular Weight:
177.16
MOL File:
118-29-6.mol
MSDS File:
SDS
Modify Date:
2024/7/25 20:04:51

N-(Hydroxymethyl)phthalimide Properties

Melting point 147-149 °C (lit.)
Boiling point 309.06°C (rough estimate)
Density 1.3312 (rough estimate)
refractive index 1.5200 (estimate)
storage temp. Store below +30°C.
form Fine Crystalline Powder
pka 13.17±0.10(Predicted)
color White
BRN 140946
InChIKey MNSGOOCAMMSKGI-UHFFFAOYSA-N
CAS DataBase Reference 118-29-6(CAS DataBase Reference)
NIST Chemistry Reference 1H-isoindole-1,3(2h)-dione, 2-(hydroxymethyl)-(118-29-6)
EPA Substance Registry System N-(Hydroxymethyl)phthalimide (118-29-6)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Safety Statements  22-24/25
WGK Germany  3
RTECS  TI5270000
TSCA  Yes
HS Code  29251995
NFPA 704
1
0 0

N-(Hydroxymethyl)phthalimide price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) H41803 N-(Hydroxymethyl)phthalimide 97% 118-29-6 100G ₹8205.35 2022-06-14 Buy
Sigma-Aldrich(India) 8.14422 N-(Hydroxymethyl)-phthalimide for synthesis 118-29-6 100G ₹3760 2022-06-14 Buy
ALFA India ALF-B21292-36 N-(Hydroxymethyl)phthalimide, 97% 118-29-6 500g ₹16491 2022-05-26 Buy
ALFA India ALF-B21292-22 N-(Hydroxymethyl)phthalimide, 97% 118-29-6 100g ₹5575 2022-05-26 Buy
TCI Chemicals (India) H0648 N-Hydroxymethylphthalimide 118-29-6 25G ₹1800 2022-05-26 Buy
Product number Packaging Price Buy
H41803 100G ₹8205.35 Buy
8.14422 100G ₹3760 Buy
ALF-B21292-36 500g ₹16491 Buy
ALF-B21292-22 100g ₹5575 Buy
H0648 25G ₹1800 Buy

N-(Hydroxymethyl)phthalimide Chemical Properties,Uses,Production

Chemical Properties

white crystalline powder

Uses

N-(Hydroxymethyl)phthalimide is used as a reactant in the synthesis of 5-[(3-aralkyl amido/imidoalkyl)phenyl]-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines as antiviral agents.

Definition

ChEBI: A primary alcohol comprising phthalimide carrying an N-hydroxymethyl substituent.

Preparation

To a flask equipped with a mechanical stirrer and condenser is added 511 gm (3.47 moles) of phthalimide, 260 ml of 40% formalin (3.47 moles), and 1750 ml of water. The mixture is refluxed for about 5-10 min or until a clear solution results (if any insoluble material remains, it is first filtered). Then the mixture is cooled for several hours. The resulting product is filtered with suction, washed with cold water, and air-dried to afford 594 gm (96%), m.p. 137-141°C.
NOTE: The product should not be oven-dried since it decomposes with the loss of formaldehyde. Recrystallization of the product from ethanol affords 94% recovery of the original material with the same melting point range.
Preparation of N-Hydroxymethylphthalimide

N-(Hydroxymethyl)phthalimide Preparation Products And Raw materials

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2-methylolisoindoline-1,3-quinone PHTHALIMIDOMETHANOL N-(HYDROXYMETHYL)PHTHALIMIDE HYDROXYMETHYL PHTHALIMIDE IFLAB-BB F0777-0575 AURORA KA-454 2-(hydroxymethyl)-1h-isoindole-3(2h)-dione 2-Hydroxymethyl-isoindole-1,3-dione Methanol, phthalimido- n-(hydroxymethyl)-phthalimid N-Methylolphthalimide Oxymethyl phthalimide AKOS BBS-00004724 2-(HYDROXYMETHYL)-1H-ISOINDOLE-1,3(2H)-DIONE oxymethylphthalimide Phthalimide, N-(hydroxymethyl)- Phthalimidomethyl alcohol phthalimidomethylalcohol 4-(Hydroxymethyl)phthalimide, 97% 1H-Isoindole-1,3(2H)-dione, 2-(hydroxymethyl)- N-Hydroxymethylphthalimide, 97 % N-(Hydroxymethyl)phthalimide, 98+% 2-(Hydroxymethyl)-1,3-dihydro-2H-isoindole-1,3-dione 2-(Hydroxymethyl)isoindoline-1,3-dione Phthalimidylmethanol N-(Hydroxymethyl)phthalimide,Phthalimidomethanol N-(Hydroxymethyl)ph 2-(hydroxymethyl)-1,3-isoindolinedione 2-(Hydroxymethyl)-1H-isoindole-1,3(2H)-dione, (Phthalimid-1-yl)methanol N-(HydroxyMrthyl)phthaliMide N-(HYDROXYMETHYL)-PHTHALIMIDE FOR SYNTHE N- hydroxyMethyladjacent benzenetwoMethyl iMide N - hydroxy Methyl phthalates forMyl iMine N-Hydroxymethylphthalimide 2-(Hydroxymethyl)-1H-isoindole-1,3(2H)-dione, 2-(Hydroxymethyl)isoindolin-1,3-dione N-(HydroxymethyL N-Hydroxymethylphthalimide> N-Hydroxyl-Methyl phthalimide 2-ACETYL-5-CHLORO-73-METHYLTHIANAPHTHENE N-(-2-HYDROXYMETHYL) PHTHALIMIDE 118-29-6 N-Substituted Maleimides, Succinimides & Phthalimides N-Substituted Phthalimides ALCOHOL Organic Building Blocks Cyclic Imides Carbonyl Compounds Building Blocks N-Substituted Maleimides, Succinimides & Phthalimides N-Substituted Phthalimides intermediates fine chemicals pharmacetical