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N-Hydroxyphthalimide

CAS No.: 524-38-9

Chemical Name:: N-Hydroxyphthalimide

Synonyms: nhpi;2-hydroxyisoindoline-1,3-dione;hydroxyphthalimide;2-hydroxyisoindole-1,3-dione;1H-Isoindole-1,3(2H)-dione, 2-hydroxy-;HOPHT;H-HYDROXY PHTHALIMIDE;2-Hydroxy-1H-isoindole-1,3(2H)-dione;2-hydroxy-2,3-dihydro-1H-isoindole-1,3-dione;f802

CBNumber:: CB2332640

Molecular Formula:: C8H5NO3

Molecular Weight:: 163.13

MOL File:: 524-38-9.mol

MSDS File:: SDS

Modify Date:: 2024/8/24 19:19:26

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N-Hydroxyphthalimide Properties

Melting point	233 °C (dec.) (lit.)
Boiling point	290.19°C (rough estimate)
Density	1.64 g/cm3
vapor pressure	0Pa at 25℃
refractive index	1.5510 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
pka	6.10±0.20(Predicted)
form	Powder
color	Yellow
Water Solubility	Slightly soluble in water.
Merck	14,4838
BRN	131208
InChIKey	CFMZSMGAMPBRBE-UHFFFAOYSA-N
LogP	0.14
CAS DataBase Reference	524-38-9(CAS DataBase Reference)
EPA Substance Registry System	1H-Isoindole-1,3(2H)-dione, 2-hydroxy- (524-38-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H335-H315-H319

Precautionary statements

P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36-37/39

WGK Germany

RTECS

TI5200000

TSCA

Yes

HazardClass

IRRITANT

HS Code

29251995

NFPA 704

	1
2		0

N-Hydroxyphthalimide price More Price(7)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	H53704	N-Hydroxyphthalimide 97%	524-38-9	5G	₹2262.43	2022-06-14	Buy
Sigma-Aldrich(India)	H53704	N-Hydroxyphthalimide 97%	524-38-9	100G	₹2749.55	2022-06-14	Buy
Sigma-Aldrich(India)	H53704	N-Hydroxyphthalimide 97%	524-38-9	500G	₹7761.53	2022-06-14	Buy
TCI Chemicals (India)	H0395	N-Hydroxyphthalimide	524-38-9	25G	₹1700	2022-05-26	Buy
TCI Chemicals (India)	H0395	N-Hydroxyphthalimide	524-38-9	100G	₹3700	2022-05-26	Buy

Product number	Packaging	Price	Buy
H53704	5G	₹2262.43	Buy
H53704	100G	₹2749.55	Buy
H53704	500G	₹7761.53	Buy
H0395	25G	₹1700	Buy
H0395	100G	₹3700	Buy

N-Hydroxyphthalimide Chemical Properties,Uses,Production

Chemical Properties

N-Hydroxyphthalimide is yellow moist powder

Uses

N-Hydroxyphthalimide，additives in to DCC method of peptide synthesis used to improve yield of optically pure product.

Application

N-Hydroxyphthalimide is used in the synthesis of a new class of antibacterials potent against macrolide resistant bacteria. Also used in the synthesis of pyrazolidines, isoxazolidines and tetrahydrooxazines.

Purification Methods

N -Hydroxyphthalimide [524-38-9] M 163.1, m 230o, ~235o(dec), 237-240o, 7.0. Dissolve the imide in H2O by adding Et3N to form the salt and while hot, acidify, cool and pour into a large volume of H2O. Filter off the solid, wash it with H2O and dry it over P2O5 in a vacuum. [Nefken & Teser J Am Chem Soc 83 1263 1961, Fieser 1 485 1976, Nefkens et al. Recl Trav Chim, Pays-Bas 81 683 1962] The O-acetyl derivative has m 178-180o (from EtOH). [Beilstein 21/11 V 100.]

N-Hydroxyphthalimide Preparation Products And Raw materials

Raw materials

2H-Isoindole-2-carboxylic acid, 1,3-dihydro-1,3-dioxo-, 1,1-dimethylethyl ester 1,3-dioxoisoindolin-2-yl acetate Benzenebutanoic acid, α-methylene-, ethyl ester Benzoic acid, 2-[(hydroxyamino)carbonyl]- 2,4-DIPHENYL-1-BUTENE-D5

Fmoc-Phe-OH 2-phenylmethoxyisoindole-1,3-dione 2,4-Diphenyl-4-methyl-1-pentene Phthaloyl dichloride

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Preparation Products

TERT-BUTYL N-(BENZYLOXY)CARBAMATE 1-Adamantanol synthetic tanning agent No.742 5-Hydroxy-1,4-naphthalenedione 1,3-Adamantanediol

O-(2,3,4,5,6-PENTAFLUOROBENZYL)HYDROXYLAMINE HYDROCHLORIDE synthetic tanning agent HV 1H-Isoindol-1-one, 3-hydroxy- N-(METHYLTHIO)PHTHALIMIDE 97

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N-Hydroxyphthalimide Suppliers

Global( 583)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Bhakti Impex	+919822268653	Pune, India	76	58	Inquiry
Sam Research Labs	+91 9873930190	Hyderabad, India	219	58	Inquiry
ANJI BIOSCIENCES	+91-9000100077 +91-9000100077	Hyderabad, India	430	58	Inquiry
HEMANT BIOSCIENCE	9848655224	Telangana, India	40	58	Inquiry
Vihita Chem Private Limited	+91-9512002673 +91-9512002673	Gujarat, India	122	58	Inquiry
TRC FINE CHEMS	+91-7400278327 +91-8097105248	Mumbai, India	73	58	Inquiry
LAASYA LABORATORIES	+91-9573171811 +91-9573171811	Telangana, India	9	58	Inquiry
Shiv Enterprise	+91-9822612471 +91-9822612471	Maharashtra, India	10	58	Inquiry
SYNGENESIS CHEMSCIENCE PRIVATE LIMITED	+91-9067779401 +91-9067779401	Maharashtra, India	58	58	Inquiry
JSK Chemicals	+919879767970	Gujarat, India	3756	58	Inquiry

Supplier	Advantage
Bhakti Impex	58
Sam Research Labs	58
ANJI BIOSCIENCES	58
HEMANT BIOSCIENCE	58
Vihita Chem Private Limited	58
TRC FINE CHEMS	58
LAASYA LABORATORIES	58
Shiv Enterprise	58
SYNGENESIS CHEMSCIENCE PRIVATE LIMITED	58
JSK Chemicals	58

N-Hydroxyphthalimide Spectrum

N-Hydroxyphthalimide(524-38-9)MS N-Hydroxyphthalimide(524-38-9)¹HNMR N-Hydroxyphthalimide(524-38-9)IR1 N-Hydroxyphthalimide(524-38-9)IR2 N-Hydroxyphthalimide(524-38-9)Raman

524-38-9(N-Hydroxyphthalimide)Related Search:

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Potassium phthalimide HOAt N-Isopropylacrylamide CAPRYLOHYDROXAMIC ACID N-Hydroxyacetamidine

D-Threo-Dihydroxyphenylserine MLMBILXCWROGFT-YVOIDUNUSA-N Droxidopa Impurity 4

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TIMTEC-BB SBB009098 N-HYDROXY-PHTALIMIDE N-HYDROXYPHTHALIMIDE 2-hydroxy-1h-isoindole-3(2h)-dione N-Hydroxyphthalimide, remainder 10-15% moisture N-Hydroxyphehtalimide N-HYDROXYMETHYL-3-METHYLOXETANE N-Hydroxyphthalimide(Nop) N-Hydroxyphthalimide,98+% N-Hydroxyphthalimide,99% N-Hydroxymethyl-3-methyloxetane（N-Hydroxyphthalimide N-(hydroxy)phthaltmde N-HYDROXYPHTHALIMIDE pure PHTHALOXIME 2-Hydroxy-2H-isoindole-1,3-dione Phthalimidyl alcohol NHPI NOP N-Hydroxyphthalimide, remainder 10-15% moisture,99% N-(hydroxy)phthaltmd N-(HYDROCU)PHTHALIMDE 2-hydroxyphthalimide Phthalimide,N-hydroxy- N-Hydroxyphthalimide N-Hydroxyphthalimide Vetec(TM) reagent grade, 97% N-Hydroxyphthalimide≥ 99% (Assay) f802 n-hydroxy-phthalimid AURORA KA-3774 LABOTEST-BB LT00005723 N-HYDROXYPHTHALIMIDE FOR SYNTHESIS 2-Hydroxy-1H-isoindole-1,3(2H)-dione, 2-Hydroxyisoindolin-1,3-dione N - hydroxy phthalates forMyl aMine N-HydroxyphthaL N-Hydroxyphthalimide> N-Hydroxyphthalimide, 98%, for synthesis Droxidopa Impurity 14 N-Hydroxyphthalimide USP/EP/BP 1H-Isoindole-1,3(2H)-dione, 2-hydroxy- nhpi 2-hydroxyisoindole-1,3-dione 2-hydroxyisoindoline-1,3-dione 2-Hydroxy-1H-isoindole-1,3(2H)-dione hydroxyphthalimide HOPHT H-HYDROXY PHTHALIMIDE 2-hydroxy-2,3-dihydro-1H-isoindole-1,3-dione N-Hydrophthalimide 524-38-9 Carbon Radical Producing Catalysts (Environmentally-friendly Oxidation) Peptide Synthesis Condensation & Active Esterification Coupling Reactions (Peptide Synthesis) Coupling Synthetic Reagents Environmentally-friendly Oxidation N-Substituted Maleimides, Succinimides & Phthalimides N-Substituted Phthalimides Active Esters/Additives