Orphenadrine
- CAS No.
- 83-98-7
- Chemical Name:
- Orphenadrine
- Synonyms
- C07935;Disipal;WS 2434;Biorphen;Orphenadine;Orphenadrin;Orphenedrine;orphenadrine;AURORA KA-7797;Ophenadrinecitrate
- CBNumber:
- CB1397020
- Molecular Formula:
- C18H23NO
- Molecular Weight:
- 269.38
- MOL File:
- 83-98-7.mol
- Modify Date:
- 2024/7/2 8:55:00
| Melting point | 25°C |
|---|---|
| Boiling point | bp12 195° |
| Density | 1.0278 (rough estimate) |
| refractive index | 1.5740 (estimate) |
| pka | pKa 8.4 (Uncertain) |
| form | Solid |
| Water Solubility | 1.801mg/L(22.5 ºC) |
| CAS DataBase Reference | 83-98-7 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 |
| RIDADR | 1851 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Toxicity | LD50 oral in mouse: 125mg/kg |
Orphenadrine Chemical Properties,Uses,Production
Uses
Relaxant (skeletal muscle); antihistaminic.
Definition
ChEBI: A tertiary amino compound which is the phenyl-o-tolylmethyl ether of 2-(dimethylamino)ethanol.
Enzyme inhibitor
This muscle relaxant and antihistaminic agent (FWfree-base = 269.39 g/mol; CAS 83-98-7) is both a muscarinic and histamine H1 receptor antagonist that also inhibits some cytochrome P450 systems. Classified as an anticholinergic drug (with 58% as potent as atropine) and an ethanolamineclass antihistamine, it also inhibits the noradrenergic transporter and NMDA receptor ion channel (Ki ≈ 6 μM). Commercially available as either the hydrochloride or citrate salt, orphenadrines used to relieve pain of muscle injuries, such as strains and sprains. Target(s): aldehyde oxidase; CYP1A2; CYP2A6; CYP3A4; CYP2B; CYP2B6; CYP2C9; CYP2C19; CYP2D6; histamine H1 receptor; N-methyl-D-aspartate (NMDA) receptor; muscarinic receptor; noradrenaline reuptake.
Orphenadrine Preparation Products And Raw materials
Orphenadrine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Varanous Labs Pvt Ltd | +91-7036248882 +91-7036248882 | Hyderabad, India | 1541 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | China | 2931 | 58 | Inquiry |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | China | 15395 | 58 | Inquiry |
| sgtlifesciences pvt ltd | +8617013299288 | China | 12382 | 58 | Inquiry |
| Alfa Chemistry | +1-5166625404 | United States | 21317 | 58 | Inquiry |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | China | 9003 | 58 | Inquiry |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | China | 11681 | 58 | Inquiry |