Exifone
- CAS No.
- 52479-85-3
- Chemical Name:
- Exifone
- Synonyms
- adlone;EXIFONE;Nsc680919;Aids060880;Aids-060880;Exifone USP/EP/BP;4-galloylpyrogallol;2,3,3'',4,4''-HEXAHYDROBENZOXYPHENONE;3,4,5,2',3',4'-HEXAHYDROXYBENZOPHENONE;2,3,3',4,4',5'-HEXAHYDROXYBENZOPHENONE
- CBNumber:
- CB1404889
- Molecular Formula:
- C13H10O7
- Molecular Weight:
- 278.21
- MOL File:
- 52479-85-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/4 16:27:49
| Melting point | 245°C |
|---|---|
| Boiling point | 674.6±55.0 °C(Predicted) |
| Density | 1.759±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 6.99±0.40(Predicted) |
| color | Yellow |
| Merck | 3915 |
| Stability | Hygroscopic |
| CAS DataBase Reference | 52479-85-3(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P501 | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RTECS | PC4995000 | |||||||||
| Toxicity | LD50 in rats (g/kg): 0.355 i.p.; 1.425 orally (Gazave) | |||||||||
| NFPA 704 |
|
Exifone Chemical Properties,Uses,Production
Description
Exifone is a nootropic indicated for the treatment of cognitive dysfunctions in geriatric patients. Its reported clinical efficacy is ascribed to pharmacological activities including activation of neuronal oxygen and glucose metabolism, free radical scavenging, and indirect effects on serotonergic and dopaminergic pathways.
Chemical Properties
yellow amorphous powder
Uses
Exifone is a nootropic drug and cognitive enhancing agent. Exifone is a free radical scavenger shown to have protective effects againts Exifone has been shown to antagonize amnesias induced by benzodiazepines in mice.
Preparation
Preparation by condensation of gallic acid with pyrogallol,
? in the presence of zinc chloride at 120° (good yield) or at 145° for 3 h (Nencki reaction);
? in the presence of zinc chloride and phosphorous oxychloride at 80° for 2 h, via Fries rearrangement.
Exifone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| chromsynth pvt ltd | +919704220374 | Hyderabad, India | 244 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| SL Drugs and Pharmaceuticals Pvt. Ltd. | +91 (40) 6661-1133 | New Delhi, India | 2688 | 50 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Shanghai Joiny Pharmaceutical Co.,LTD | +8613681955282 | China | 249 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | China | 34571 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24822 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |