Germacrone
- CAS No.
- 6902-91-6
- Chemical Name:
- Germacrone
- Synonyms
- Germacron;3,7-Cyclodecadien-1-one, 3,7-dimethyl-10-(1-methylethylidene)-, (E,E)-;3,7-Cyclodecadien-1-one, 3,7-dimethyl-10-(1-methylethylidene)-, (3E,7E)-;GERMACRONE;GERMACRONE(RG);GerMacrol (obsol;(E,E)-GerMacrone;(E,E)-Germacra-3,7(11),9-trien-6-one;Germacra-3,7(11),9-trien-6-one, (E,E)-;Germacrone, 98%, from Curcuma zedoaria (Christm.) Rosc
- CBNumber:
- CB1497650
- Molecular Formula:
- C15H22O
- Molecular Weight:
- 218.33
- MOL File:
- 6902-91-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/16 18:25:32
| Melting point | 55-58 °C |
|---|---|
| Boiling point | 153-157 °C(Press: 13 Torr) |
| Density | 0.9908 g/cm3 |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White to Off-White |
| λmax | 309nm(MeOH)(lit.) |
| BRN | 2047453 |
| Stability | Light Sensitive |
| LogP | 4.760 (est) |
| CAS DataBase Reference | 6902-91-6 |
| NIST Chemistry Reference | 3,7-Cyclodecadien-1-one, 3,7-dimethyl-10-(1-methylethylidene)-, (e,e)-(6902-91-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280-P305+P351+P338-P337+P313 | |||||||||
| Safety Statements | 23-24/25 | |||||||||
| RTECS | GU2210000 | |||||||||
| HS Code | 29142990 | |||||||||
| NFPA 704 |
|
Germacrone price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 42924 | Germacrone analytical standard | 6902-91-6 | 10MG | ₹82085.98 | 2022-06-14 | Buy |
| TCI Chemicals (India) | G0519 | Germacrone min. 98.0 % | 6902-91-6 | 20MG | ₹5300 | 2022-05-26 | Buy |
| TCI Chemicals (India) | G0519 | Germacrone min. 98.0 % | 6902-91-6 | 100MG | ₹14800 | 2022-05-26 | Buy |
Germacrone Chemical Properties,Uses,Production
Description
Germacrone is a sesquiterpene that has been found in gingeraceae plants and has diverse biological activities. It inhibits pseudorabies virus (PRV) replication in Vero cells when used at concentrations ranging from 10 to 150 μM. Germacrone (50-250 μM) enhances cytotoxicity and apoptosis induced by doxorubicin in doxorubicin-resistant MCF-7/adr cells. In vivo, germacrone (5, 10, and 20 mg/kg) reduces body weight gain, visceral fat pad weight, serum insulin and plasma glucose levels, and hepatic lipid levels in a mouse model of high-fat diet-induced obesity. It decreases brain malondialdehyde (MDA) levels and activity of superoxide dismutase (SOD) and glutathione peroxidase (GPX), as well as reduces infarct volume in a rat model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).
Uses
Germacrone is an antiviral isolate of Geranium macrorrhizum which inhibits and prevents early stage influenza virus infection. It also inhibits the proliferation of glioma cells by promoting apoptosis.
Hazard
A poison by ingestion
Safety Profile
A poison by ingestion. When heated to decomposition it emits acrid smoke and irritating vapors.
Germacrone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81148696 +8615536356810 | China | 1252 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29900 | 58 | Inquiry |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | China | 3424 | 58 | Inquiry |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | China | 2995 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | China | 12330 | 58 | Inquiry |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | China | 10326 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | China | 34571 | 58 | Inquiry |