Zaragozic acid A
- CAS No.
- 142561-96-4
- Chemical Name:
- Zaragozic acid A
- Synonyms
- Aids111671;Gr 105155x;Aids-111671;Squalestatin 1;Squalestatin A;Zaragozic Acid;ZARAGOZIC ACID A;DFKDOZMCHOGOBR-NCSQYGPNSA-N;Squalestatin A, Squalestatin S1, L 694599;L-Erythro-L-glycero-D-altro-7-trideculo-7,4-furanosonic acid, 2,7-anhydro-3,4-di-C-carboxy-8,9,10,12,13-pentadeoxy-10-methylene-12-(phenylmethyl)-, 11-acetate 5-[(2E,4S,6S)-4,6-dimethyl-2-octenoate], (7S)-
- CBNumber:
- CB1505421
- Molecular Formula:
- C35H46O14
- Molecular Weight:
- 690.73
- MOL File:
- 142561-96-4.mol
- Modify Date:
- 2023/5/18 11:31:06
| alpha | D22 +18.3° (c = 0.60 in CHCl3); D25 +37° (c = 1.29 in methanol) |
|---|---|
| Boiling point | 850.1±65.0 °C(Predicted) |
| Density | 1.35±0.1 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | Soluble in DMSO |
| form | solid |
| pka | 1.47±0.70(Predicted) |
| color | white to light tan |
| CAS DataBase Reference | 142561-96-4 |
Zaragozic acid A Chemical Properties,Uses,Production
Chemical Properties
White to light tan solid. Soluble in ethanol (10 mg/ml), methanol, DMF, DMSO (10 mg/ml), and water (moderate).
Uses
Zaragozic acid A is the major metabolite of a class of unusual bicyclic tricarboxylic acids, produced by a number of fungi in the genera Curvularia, Exserohilum, Setosphaeria and others, discovered at Merck and Glaxo in the early 1990s. In nature, zaragozic acid A acts as broad spectrum antifungal but its mode of action as an inhibitor of squalene synthase, involved in sterol biosynthesis, lead to investigation as a cholesterol lowering agent. Zaragozic acid A prepared by BioAustralis is presented as the free acid rather than the tri-sodium salt to avoid stability problems associated with hydrolysis of the salt.
Definition
ChEBI: Zaragozic acid A is a polyketide isolated from fungi that is a potent inhibitor of fungal and mammalian squalene synthase. It has a role as an EC 2.5.1.21 (squalene synthase) inhibitor and a fungal metabolite. It is a tricarboxylic acid, an acetate ester, a cyclic ketal, an oxabicycloalkane, a tertiary alcohol and a polyketide.
Application
Zaragozic Acid A is a squalene synthetase inhibitor. it targeted squalene synthase and lowered the cholesterol levels in vivo of marmosets.
Biological Activity
Zaragozic acid A is an inhibitor of acute liver cholsterol synthesis (50% inhibition dose 200 μg/ kg) with Ki value of 78pM. It inhibited cholesterol synthesis in Hep G2 cells.
Zaragozic acid A Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| BOC Sciences | 16314854226; +16314854226 | United States | 19743 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
| Shanghai Maclean Biochemical Technology Co., LTD | 021-50706066 15221275939 | China | 29803 | 58 | Inquiry |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | China | 8141 | 58 | Inquiry |
| Shanghai Universal Biotech Co.,Ltd | 18768175414 | China | 24998 | 58 | Inquiry |
| Cayman Chemical Company | (800) 364-9897 | United States | 6618 | 81 | Inquiry |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | China | 8740 | 58 | Inquiry |
| Riedel-de Haen AG | 800 558-9160 | United States | 6825 | 87 | Inquiry |
| CHEMICAL LAND21 | 82- 2 -783 - 8063 | South Korea | 6315 | 74 | Inquiry |