LATRUNCULIN A

LATRUNCULIN A Structure
CAS No.
76343-93-6
Chemical Name:
LATRUNCULIN A
Synonyms
LAT-A;NSC 613011;LATRUNCULIN A;Latrunculin A (LAT-A);LATRUNCULIN A, LATRUNCULIA MAGNIFICA;Latrunculin A, Latrunculia magnifica - CAS 76343-93-6 - Calbiochem;4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-Hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl)-2-thiazolidinone;(4R)-4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-Hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-2-thiazolidinone;2-Thiazolidinone, 4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-, (4R)-;[1R-[1R*, 4Z, 8E, 10Z, 12S*, 15R*, 17R*(R*)]]-4-(17-HYDROXY-5,12-DIMETHYL-3-OXO-2,16-DIOXABICYCLO[13.3.1]NONADECA-4,8,10-TRIEN-17-YL)-2-THIAZOLIDINONE
CBNumber:
CB1679575
Molecular Formula:
C22H31NO5S
Molecular Weight:
421.55
MOL File:
76343-93-6.mol
MSDS File:
SDS
Modify Date:
2023/6/30 15:45:59

LATRUNCULIN A Properties

alpha D24 +152° (c = 1.2 in chloroform)
storage temp. -20°C
solubility DMSO: soluble
form waxy solid
color yellow
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS02
Signal word  Danger
Hazard statements  H225
Precautionary statements  P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501
WGK Germany  3
NFPA 704
3
0 0

LATRUNCULIN A price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) L5163 Latrunculin A from sea sponge, ≥85% (HPLC), waxy solid 76343-93-6 100μG ₹36144.68 2022-06-14 Buy
Sigma-Aldrich(India) 428021 Latrunculin A, Latrunculia magnifica - CAS 76343-93-6 - Calbiochem Latrunculin A, CAS 76343-93-6, is a cell-permeable marine toxin that disrupts microfilament organization in cultured cells by the formation of a 1:1 c 76343-93-6 100μG ₹30660 2022-06-14 Buy
Product number Packaging Price Buy
L5163 100μG ₹36144.68 Buy
428021 100μG ₹30660 Buy

LATRUNCULIN A Chemical Properties,Uses,Production

Description

Actin disruption is used to study cell functions in vitro (e.g., migration, endocytosis) and in vivo (e.g., tumor cell invasion). Latrunculin A is a bioactive 2-thiazolidinone macrolide derived from sponges that sequesters G-actin and prevents F-actin assembly. It binds monomeric actin with 1:1 stoichiometry and can be used to block actin polymerization both in vitro (Kd = 0.2 μM) and in cells (0.5 μM, 30 min).{ Latrunculin A (1-10 μM) causes depolymerization of tumor cell cytoskeleton within ten minutes. Overnight treatment of cells with latrunculin A (10 μM) strongly suppresses actin synthesis. Prolonged cell treatment blocks dexamethasone-induced changes in actin cytoskeleton with no effect on cell viability.

Uses

Latrunculin A, Latrunculia magnifica is a stabilizer of monomeric G-actin and polymerization inhibitor.

Definition

ChEBI: A bicyclic macrolide natural product consisting of a 16-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica and from the Fiji Islands sponge Cacospongia myc fijiensis. Latrunculin A inhibits actin polymerisation, microfilament organsation and microfilament-mediated processes.

General Description

Latrunculin A, a toxin extracted from the red sea sponge Latrunculia magnifica. It participates in vitro in the morphological alteration of the polymerization of pure actin. It forms a complex by binding with the nucleotide cleft of actin for actin filaments elongation.

LATRUNCULIN A Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 56)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Alfa Chemistry +1-5166625404 United States 21317 58 Inquiry
LEAPCHEM CO., LTD. +86-852-30606658 China 43348 58 Inquiry
Shanghai Acmec Biochemical Technology Co., Ltd. +undefined18621343501 China 33350 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-400-6206333 18521732826 China 25014 65 Inquiry
Nantong Hanfang Biotechnology Co. , Ltd. 18616537568 China 30968 58 Inquiry
TargetMol Chemicals Inc. 15002134094 China 28118 58 Inquiry
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652 China 4663 58 Inquiry
Shanghai klamar Reagent Co., LTD 4001650900 13817534909 China 10709 58 Inquiry
[1R-[1R*, 4Z, 8E, 10Z, 12S*, 15R*, 17R*(R*)]]-4-(17-HYDROXY-5,12-DIMETHYL-3-OXO-2,16-DIOXABICYCLO[13.3.1]NONADECA-4,8,10-TRIEN-17-YL)-2-THIAZOLIDINONE LAT-A LATRUNCULIN A LATRUNCULIN A, LATRUNCULIA MAGNIFICA LAT-A, [1R-[1R*, 4Z, 8E, 10Z, 12S*, 15R*, 17R*(R*)]]-4-(17-Hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl)-2-thiazolidinone (4R)-4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-Hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-2-thiazolidinone 4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-Hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl)-2-thiazolidinone NSC 613011 Latrunculin A, Latrunculia magnifica - CAS 76343-93-6 - Calbiochem 2-Thiazolidinone, 4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-, (4R)- Latrunculin A (LAT-A) 76343-93-6 C22H31NO5S Cytoskeleton and Extracellular Matrix BioChemical Actin Inhibitors and Probes Cell Biology Cell Signaling and Neuroscience