2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide
![2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide Structure](CAS/GIF/442633-00-3.gif)
- CAS No.
- 442633-00-3
- Chemical Name:
- 2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide
- Synonyms
- CK 666;CK-0944666;CK 666 (CK 0944666);Arp2/3 Complex Inhibitor I, CK-666;2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide;Benzamide, 2-fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-;Inhibitor,HIV,meshwork,CK-666,Actin-related protein 2/3 complex,allosteric,CK 666,state,effector,active,inhibit,CK666,trabecular,Human immunodeficiency virus,Arp2/3 Complex
- CBNumber:
- CB52518908
- Molecular Formula:
- C18H17FN2O
- Molecular Weight:
- 296.34
- MOL File:
- 442633-00-3.mol
- Modify Date:
- 2023/6/30 15:45:59
| Boiling point | 528.2±50.0 °C(Predicted) |
|---|---|
| Density | 1.235±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥25mg/mL |
| pka | 13.86±0.46(Predicted) |
| form | powder |
| color | white to tan |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0006 | CK-666 ≥98% (HPLC), powder | 442633-00-3 | 5MG | ₹13552.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0006 | CK-666 ≥98% (HPLC), powder | 442633-00-3 | 25MG | ₹51884.23 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 182515 | Arp2/3 Complex Inhibitor I, CK-666 - CAS 442633-00-3 - Calbiochem Arp2/3 Complex Inhibitor I, CK-666, CAS 442633-00-3, is a cell-permeable selective inhibitor of actin assembly mediated by actin-related protein Arp2/ | 442633-00-3 | 25MG | ₹20000 | 2022-06-14 | Buy |
2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide Chemical Properties,Uses,Production
Uses
CK-666 may be used to study Arp2/3-mediated structural changes in cells.
General Description
A cell-permeable indolyl-fluorobenzamide compound that selectively inhibits actin assembly mediated by actin-related protein Arp2/3 complex of human, bovine, fission yeast S. pombe, and budding yeast S. cerevisiae origin (IC50 = 4, 17, 5, and 12 μM, respectively), without affecting S. pombe formin domain Cdc12(FH2)-mediated or the spontaneous actin polymerization. Shown to inhibit the actin filament "comet tails" formation around intracellular Listeria in infected SKOV3 cells (IC50 = 7 μM) in a reversible manner. Structrual studies indicate that CK-666 targets a pocket formed between subdomain 4 of Arp2 and subdomain 1 of Arp3, preventing Arp2/3 from shifting into an active conformation upon N-WASP-VCA binding. CK-666 and CK-869 (Cat. No. 182516) exhibit different modes of binding, resulting in their different yeast cross-reactivities. CK-689 (Cat. No. 182517) can serve as a negative control.
Biochem/physiol Actions
CK-666 binds to Arp2/3 complex, stabilizes the inactive state of the complex and prevents its movement into active conformation.
2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide Preparation Products And Raw materials
Raw materials
Preparation Products
2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
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| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30250 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | +86-18521732826 | China | 48465 | 58 | Inquiry |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | China | 3433 | 58 | Inquiry |
| Henan Alpha Chemical Co., Ltd. | 0371-55013243 15324716602 | China | 10010 | 58 | Inquiry |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | China | 62163 | 58 | Inquiry |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | China | 9806 | 58 | Inquiry |
| TargetMol Chemicals Inc. | 4008200310 | China | 24647 | 58 | Inquiry |