Chinese english Japanese Germany Korea

(Z)-CAPSAICIN

(Z)-CAPSAICIN Structure
CAS No.
25775-90-0
Chemical Name:
(Z)-CAPSAICIN
Synonyms
civamide;Zucapsaicin;(Z)-CAPSAICIN;cis-capsaicin;cis-Capsaicine;(z)-6-nonenamid;Zucapsaicin,civaMide;Civamide cis-Capsaicin;(Z)-Capsaicin、Civamide;Civamide (Zucapsaicin)
CBNumber:
CB1694480
Molecular Formula:
C18H27NO3
Molecular Weight:
305.41
MOL File:
25775-90-0.mol
MSDS File:
SDS
Modify Date:
2024/4/24 17:21:45
Request For Quotation

(Z)-CAPSAICIN Properties

Melting point 70 °C
Boiling point 511.5±50.0 °C(Predicted)
Density 1.041±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pka 9.76±0.20(Predicted)
color White to Off-White
Stability Light Sensitive

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08,GHS05,GHS06
Signal word  Danger
Hazard statements  H301-H335-H334-H317-H318-H315
Precautionary statements  P280-P305+P351+P338-P310-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P261-P285-P304+P341-P342+P311-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P310-P321-P330-P405-P501
Toxicity LD50 intraperitoneal in mouse: 25mg/kg

(Z)-CAPSAICIN Chemical Properties,Uses,Production

Description

Zucapsaicin is a topical analgesic that was approved in Canada in July 2010 for use in conjunction with oral COX-2 inhibitors or NSAIDs to relieve severe pain in adults with osteoarthritis of the knee. Zucapsaicin is the cis-isomer of the natural product capsaicin. Capsaicin is available without a prescription in creams, lotions, and patches for the treatment of neuropathic and musculoskeletal pain. Zucapsaicin is available as a 0.075% by weight cream. The advantages of zucapsaicin compared with capsaicin are reported to be a lesser degree of local irritation (stinging, burning, erythema) in patients and a greater degree of efficacy in preclinical animal models of pain. The analgesic action of zucapsaicin and capsaicin is mediated through the transient receptor potential vanilloid type 1 (TRPV1) channel.

Uses

(Z)-CAPSAICIN is used as a tool in neurobiological research. Prototype vanilloid receptor agonist.

Clinical Use

Zucapsaicin, the cis-isomer of the natural product capsaicin, is a topical analgesic that was initially developed by Winston Pharmaceuticals and approved in Canada in July 2010 for the treatment of severe pain in adults with osteoarthritis of the knee. The advantages of zucapsaicin compared with naturally-occurring capsaicin are reported to be a lesser degree of local irritation (stinging, burning, erythema) in patients and a greater degree of efficacy in preclinical animal models of pain. The analgesic action of both zucapsaicin and capsaicin is mediated through the transient receptor potential vanilloid type 1 (TRPV1) channel, a ligand-gated ion channel expressed in the spinal cord, brain, and localized on neurons in sensory projections to the skin, muscles, joints, and gut.

(Z)-CAPSAICIN Preparation Products And Raw materials

Raw materials

Preparation Products

(Z)-CAPSAICIN Suppliers

Global( 120)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
BDR Pharmaceuticals International Pvt Ltd +91-2240560560 +91-7718884418 Maharashtra, India 206 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Hebei Mojin Biotechnology Co., Ltd +86 13288715578 +8613288715578 China 12459 58 Inquiry
Ouhuang Engineering Materials (Hubei) Co., Ltd +86-86177 China 2952 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29901 58 Inquiry
Hebei Guanlang Biotechnology Co., Ltd. +86-19930503282 China 8828 58 Inquiry
Supplier Advantage
BDR Pharmaceuticals International Pvt Ltd 58
A.J Chemicals 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
SynZeal Research Pvt Ltd 58
Pharma Affiliates 58
CLEARSYNTH LABS LTD. 58
Hebei Mojin Biotechnology Co., Ltd 58
Ouhuang Engineering Materials (Hubei) Co., Ltd 58
career henan chemical co 58
Hebei Guanlang Biotechnology Co., Ltd. 58

25775-90-0((Z)-CAPSAICIN)Related Search:

Nonivamide Z-VAD-FMK ZSTK474 Z-Vad-fmk, non-methylated ZT-12-037-01
(E)-CAPSAICIN,CAPSAICIN, NATURAL (Z)-CAPSAICIN Capsaicin pure,capsaicin(fromoleoresinofcapsicum)plusrelatedcapsaicinoid Capsicumoleoresin/Capsaicin,10%,Capsicumoleoresin/Capsaicin,6.2%,Capsicumoleoresin/Capsaicin,3.3% 1-NONENE
Capsaicin-D3 Anti-Capsaicin Receptor (Ab-1), Rat (Rabbit) CAPSAICIN, EMULSION LIGUID CAPSAICIN RECEPTOR (AB-1) POLYCLONAL ANTIBODY CAPSAICIN [14C]
CAPSAICIN, NATURAL SOLUTION 100UG/ML IN TOLUENE 1ML CAPSAICIN, NATURAL 100MG [R] N-VANILLYLNONANAMIDE (SYNTHETIC CAPSAICIN) = N-[94-HYDROXY-3-METHOXYPHENYL)METHYL]NONANAMIDE
chevron_left

1of4

chevron_right
(Z)-N-[(4-HYDROXY-3-METHOXYPHENYL)METHYL]-8-METHYL-6-NONENAMIDE Zucapsaicin (Z)-CAPSAICIN (z)-6-nonenamid cis-capsaicin civamide n-((4-hydroxy-3-methoxyphenyl)methyl)-8-methyl-6-nonenamide(z)- (Z)-8-Methyl-N-(4-hydroxy-3-methoxybenzyl)-6-noneneamide (Z)-N-(4-Hydroxy-3-methoxybenzyl)-8-methyl-6-nonenamide cis-Capsaicine 8-Methyl-N-vanillyl-6-nonenamide Civamide cis-Capsaicin (Z)-N-[(4-Hydoxy-3-methoxyphenyl)methyl]-8-metyl-6-nonenamide (6Z)-N-[(4-Hydroxy-3-Methoxyphenyl)Methyl]-8-Methyl-6-nonenaMide (Z)-8-Methyl-N-vanillyl-6-nonenaMide (Z)-N-(4-Hydroxy-3-Methoxybenzyl)-8-Methylnon-6-enaMide Zucapsaicin,civaMide (Z)-Capsaicin、Civamide Zucapsaicin（cis-Capsaicin） ZUCAPSAICIN;CIS-CAPSAICIN;CIVAMIDE;(Z)-CAPSAICIN (Z)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide Civamide (Zucapsaicin) 6-Nonenamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-, (6Z)- (Z)-CAPSAICIN / Zucapsaicin 25775-90-0 Vanilloid/TRPV channel Anilines, Aromatic Amines and Nitro Compounds Amines Aromatics Intermediates & Fine Chemicals Pharmaceuticals