Dihydrocapsaicin
- CAS No.
- 19408-84-5
- Chemical Name:
- Dihydrocapsaicin
- Synonyms
- CAPSAICINE;N-(3-Methoxy-4-hydroxybenzyl)-8-methylnonanamide;(E)-8-METHYL-NON-6-ENOIC ACID 4-HYDROXY-3-METHOXY-BENZYLAMIDE;FEMA 2787;FEMA 3404;CCRIS1589;(E)-CAPSAICIN;ihydrocapsaicin;Dihydrocapsaicin;CAPSAICIN, NATURAL
- CBNumber:
- CB3112966
- Molecular Formula:
- C18H29NO3
- Molecular Weight:
- 307.43
- MOL File:
- 19408-84-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:04
| Melting point | 62-65 °C(lit.) |
|---|---|
| Boiling point | 497.4±35.0 °C(Predicted) |
| Density | 1.026±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | H2O: insoluble |
| pka | 9.76±0.20(Predicted) |
| form | White to off-white solid. |
| color | White to off-white |
| BRN | 2815150 |
| InChIKey | XJQPQKLURWNAAH-UHFFFAOYSA-N |
| LogP | 3.556 (est) |
| CAS DataBase Reference | 19408-84-5(CAS DataBase Reference) |
| EPA Substance Registry System | Dihydrocapsaicin (19408-84-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P301+P310-P305+P351+P338 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25-37/38-41-42/43-36/37/38 | |||||||||
| Safety Statements | 22-26-28-36/39-45-36/37/39 | |||||||||
| RIDADR | UN 2811 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | RA8530000 | |||||||||
| F | 10-21 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29399990 | |||||||||
| NFPA 704 |
|
Dihydrocapsaicin price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | M1022 | Dihydrocapsaicin from Capsicum sp., ≥85% | 19408-84-5 | 50MG | ₹13542.08 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR2627 | Dihydrocapsaicin pharmaceutical secondary standard, certified reference material | 19408-84-5 | 50MG | ₹22764.98 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M1022 | Dihydrocapsaicin from Capsicum sp., ≥85% | 19408-84-5 | 250MG | ₹43668.05 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M1022 | Dihydrocapsaicin from Capsicum sp., ≥85% | 19408-84-5 | 1G | ₹121369.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 03813 | Dihydrocapsaicin analytical standard | 19408-84-5 | 5MG | ₹6365.1 | 2022-06-14 | Buy |
Dihydrocapsaicin Chemical Properties,Uses,Production
Description
Dihydrocapsaicin is a terpene alkaloid that has been found in Capsicum and has diverse biological activities. It is active against E. faecalis, B. subtilis, S. aureus, P. aeruginosa, K. pneumoniae, E. coli, and C. albicans (MICs = 0.6-10 μg/ml). Dihydrocapsaicin scavenges DPPH and ABTS radicals in cell-free assays. It increases LC3-II, a marker of autophagy, and catalase levels and reduces reactive oxygen species (ROS) production in normal WI38 lung fibroblasts and H1299, but not A549 or H460, lung cancer cells when used at a concentration of 200 μM. Dihydrocapsaicin is an agonist of transient receptor potential vanilloid 1 (TRPV1) and inhibits NETosis induced by phorbol 12-myristate 13-acetate (TPA; ) in isolated human neutrophils. It induces cortical and systemic hypothermia and reduces infarct volume in a rat model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO) when administered at a dose of 0.5 mg/kg, i.p.
Chemical Properties
White Solid
Uses
Dihydrocapsaicin has been used as a reference standard for the identification of dihydrocapsaicin in blood and tissue samples by high performance liquid chromatography (HPLC) combined with tandem mass spectrometry (MS) and in tomato-based salsas by enzyme immunoassay (EIA) and LC with fluorescent detection.
It may be used as a reference standard for the determination of dihydrocapsaicin in Capsicum fruit samples by HPLC equipped with a Surveyor photodiode array (PDA) detector and in rat plasma by HPLC-triple quadrupole MS with electrospray ionization (ESI) in selected reaction monitoring (SRM) mode.
General Description
Dihydrocapsaicin belongs to the capsaicinoid group of compounds which are responsible for the pungency of capsicum fruits.
Dihydrocapsaicin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Pharmed Medicare (P) Ltd. | +91 80 841 0158 | New Delhi, India | 71 | 65 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 | China | 988 | 58 | Inquiry |
| BINBO BIOLOGICAL CO.,LTD | +8618629063126 | China | 346 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21667 | 55 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29888 | 58 | Inquiry |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | China | 2136 | 58 | Inquiry |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | China | 3772 | 58 | Inquiry |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | China | 3000 | 58 | Inquiry |