DROXIDOPA
- CAS No.
- 23651-95-8
- Chemical Name:
- DROXIDOPA
- Synonyms
- L-threo-3,4-Dihydroxyphenylserine;Droxidopa (JAN);l-dops;SM 5688;roxidopa;DROXIDOPA;Droxydopa;l-threodops;Droxidopa>Droxidopa-13C6
- CBNumber:
- CB1699324
- Molecular Formula:
- C9H11NO5
- Molecular Weight:
- 213.19
- MOL File:
- 23651-95-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/23 14:28:52
| Melting point | 232-235° (dec); mp 229-232° (dec) (Ohashi) |
|---|---|
| alpha | D20 -39° (c = 1 in 1N aq HCl); D20 -42.0° (c = 1 in 1N aq HCl) |
| Boiling point | 549.8±50.0 °C(Predicted) |
| Density | 1.608±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: ≥3mg/mL |
| pka | 2.09±0.24(Predicted) |
| form | powder |
| color | white to tan |
| Merck | 14,3457 |
| Stability | Hygroscopic |
| CAS DataBase Reference | 23651-95-8 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | VT9626010 | |||||||||
| HS Code | 29225090 | |||||||||
| NFPA 704 |
|
DROXIDOPA price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | D9446 | L-DOPS ≥98% (HPLC) | 23651-95-8 | 5MG | ₹14451.38 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D9446 | L-DOPS ≥98% (HPLC) | 23651-95-8 | 25MG | ₹58390.05 | 2022-06-14 | Buy |
| TCI Chemicals (India) | D4235 | Droxidopa | 23651-95-8 | 50MG | ₹8000 | 2022-05-26 | Buy |
| TCI Chemicals (India) | D4235 | Droxidopa | 23651-95-8 | 200MG | ₹24000 | 2022-05-26 | Buy |
DROXIDOPA Chemical Properties,Uses,Production
Description
Droxidopa is a synthetic amino acid precursor of (-)-norepinephrine which is absorbed from the gut and metabolized to norepinephrine. In Parkinsonian patients, droxidopa added to existing levodopa/decarboxylase inhibitor therapy produces significant improvements in retropulsion, dysarthria and muscular rigidity refractory to other treatments; however, tremor was unaffected.
Chemical Properties
Off-White Solid
Uses
The L-threo-form Droxidopa. A synthetic amino acid precursor of Norepinephrine (N674500). Antiparkinsonian.
Definition
ChEBI: A serine derivative that is L-serine substituted at the beta-position by a 3,4-dihydroxyphenyl group. A prodrug for noradrenalone, it is used for treatment of neurogenic orthostatic hypotension
General Description
L-DOPS, also called L-threo 3,4-Dihydroxyphenylserine or droxidopa is a catecholamine. L-DOPS has many clinical advantages and may be useful for treating norepinephrine deficiency. It is used for treating neurogenic orthostatic hypotension and improves norepinephrine levels. L-DOPS mediates reduction of amyloid plaques and could have a therapeutic potential for treating amyloid pathology.
DROXIDOPA Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Lupin Ltd | +91-8019896181 +91-8019896181 | Maharashtra, India | 93 | 58 | Inquiry |
| Piramal Pharma Solutions | +919892735994 | Maharashtra, India | 48 | 58 | Inquiry |
| Hetero Drugs Limited | +91-4023704923 +91-4023704923 | Telangana, India | 296 | 58 | Inquiry |
| Aruvi Labs | +91-8056181939 +91-8056181939 | Tamil Nadu, India | 149 | 58 | Inquiry |
| Laxai Life Sciences | +91-4023480125 +91-4023480125 | Hyderabad, India | 21 | 58 | Inquiry |
| Lifecare Laboratories Pvt. Ltd | +91-4023750123 +91-4023750123 | Hyderabad, India | 18 | 58 | Inquiry |
| Mylan Laboratories Ltd | +91-4023550543 +91-4030866666 | Telangana, India | 150 | 58 | Inquiry |
| Apicore Pharmaceuticals Pvt Ltd | +91-2662267177 +91-2662267166 | Gujarat, India | 181 | 58 | Inquiry |
| Turtle Pharma Private Limited | +91-9850998504 +91-9850998504 | Maharashtra, India | 27 | 58 | Inquiry |
| Molsyns Research | +91-9586858886 +91-9586858886 | Gujarat, India | 418 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Lupin Ltd | 58 |
| Piramal Pharma Solutions | 58 |
| Hetero Drugs Limited | 58 |
| Aruvi Labs | 58 |
| Laxai Life Sciences | 58 |
| Lifecare Laboratories Pvt. Ltd | 58 |
| Mylan Laboratories Ltd | 58 |
| Apicore Pharmaceuticals Pvt Ltd | 58 |
| Turtle Pharma Private Limited | 58 |
| Molsyns Research | 58 |