Bromelain
| storage temp. | −20°C |
|---|---|
| form | powder |
| color | yellow-brown |
| Water Solubility | soluble |
| CAS DataBase Reference | 9001-00-7 |
| EPA Substance Registry System | Bromelain, juice (9001-00-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H319-H334-H335 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P-P261-P285-P304+P341-P342+P311-P501 | |||||||||
| Hazard Codes | B,Xn | |||||||||
| Risk Statements | 36/37/38-42 | |||||||||
| Safety Statements | 22-24-26-36/37-36/37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-21 | |||||||||
| HS Code | 35079090 | |||||||||
| NFPA 704 |
|
Bromelain price More Price(2)
Bromelain Chemical Properties,Uses,Production
Definition
ChEBI: Bromelain is a milk-clotting proteolytic enzyme. It is precipitated from pineapple juice with acetone or ammonium sulfide. Protein-digesting and milk-clotting enzymes found in PINEAPPLE fruit juice and stem tissue. Enzymes from the two sources are distinguished as fruit bromelain and stem bromelain. This enzyme was formerly listed as EC 3.4.22.4.
General Description
Bromelain is a crude extract from pineapple that contains a mixture of different proteases as well as phosphatases, glucosidases, peroxidases, cellulases, glycoproteins, and carbohydrates. Of the different proteases available in a bromelain mixture, commercial bromelain is usually produced from the stem part (stem bromelain), although other pineapple parts contain a certain amount of bromelain as well. Bromelain is an effective anticancer therapeutic agent, as a result of the systemic response to multiple cellular and molecular targets induced by this enzyme; however, the real underlying mechanisms are yet to be fully understood. Also, this enzyme has the potential to be used as an antibiotic since it can modify the permeability of organs and tissues to different drugs. Moreover, bromelain is used in a debridement cream formulation to eliminate burn debris and accelerate the healing process, and can inhibit platelet aggregation, especially for patients affected with heart attack and stroke, and reduce arthritis pathogenesis since it has analgesic properties that can influence pain mediators, and prevent diarrhea by interacting with intestinal secretory signaling pathways. In addition to food and medical applications, bromelain is used in the cosmetic industry to treat various skin conditions. It is also used as a stain remover in teeth cleaning/whitening. In the textile industry, it is used to improve the dyeing properties of protein fibers such as wool and silk and assist in the cocoon-softening process in silk production.
Mechanism of action
The major action of bromelain appears to be proteolytic in nature, although evidence also suggests an immunomodulatory and hormone-like activity acting via intracellular signaling pathways. Bromelain has been shown to reduce cell surface receptors, such as hyaluronan receptor CD44, which is associated with leukocyte migration and induction of proinflammatory mediators. Additionally, it is also reported to significantly reduce CD4 + T-cell infiltrations, which are primary effectors in animal models of inflammation in the gut. It has been found to be effective in improvement of clinical and histologic severity of colonic inflammation in a murine colitis model of IL-10-deficient mice[1].
References
[1] Salibay, Cristina C., et al. "Natural product–derived drugs for the treatment of inflammatory bowel diseases (IBD)." Inflammation and Natural Products (2021).
Bromelain Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Vedzon Healthcare Pvt Ltd | +91-9322176000 +91-9322176000 | Maharashtra, India | 51 | 58 | Inquiry |
| PANCHSHEEL ORGANICS LTD | +91-9821053955 +91-9324201019 | Mumbai, India | 82 | 58 | Inquiry |
| Fido Pharma | +91-9876274767 +91-9167231289 | Haryana, India | 23 | 58 | Inquiry |
| Bioprex Labs | +91-8888556779 +91-8605824777 | Maharashtra, India | 8 | 58 | Inquiry |
| Meteoric Biopharmaceuticals Pvt. Ltd. | +91-8511121361 +91-8511121361 | Mumbai, India | 71 | 58 | Inquiry |
| Excellent Biotechnologies | +91-8904857846 +91-8032550712 | Karnataka, India | 14 | 58 | Inquiry |
| Advanced Enzymes | +91-2241703200 +91-9769214357 | NaviMumbai, India | 10 | 58 | Inquiry |
| Enzyme BioScience pvt Ltd | +91-9722913685 +91-8690076795 | Gujarat, India | 25 | 58 | Inquiry |
| Bio Gen Extracts Pvt Ltd | +91-7022903130 +91-9108058822 | Karnataka, India | 11 | 58 | Inquiry |
| Apollo ingredients Pvt Ltd | +91-7219888886 | Maharashtra, India | 31 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Vedzon Healthcare Pvt Ltd | 58 |
| PANCHSHEEL ORGANICS LTD | 58 |
| Fido Pharma | 58 |
| Bioprex Labs | 58 |
| Meteoric Biopharmaceuticals Pvt. Ltd. | 58 |
| Excellent Biotechnologies | 58 |
| Advanced Enzymes | 58 |
| Enzyme BioScience pvt Ltd | 58 |
| Bio Gen Extracts Pvt Ltd | 58 |
| Apollo ingredients Pvt Ltd | 58 |
Related articles
- Bromelain: Supplement, Benefits and Side effects
- Bromelain is a combination of several thiol endopeptidases and others including various protease inhibitors, glucosidase, cell....
- Jun 7，2024
- Bromelain: Source, Antimicrobial Efficacy and Therapeutic Applications
- Bromelain, a protein found in pineapple stems, has diverse applications in medicine due to its antimicrobial properties, and p....
- Jan 22，2024
- Bromelain：used in medicine, cosmetics, and food industries.
- Bromelain, from pineapples, is a proteolytic enzyme with anti-inflammatory benefits, widely used in medicine, cosmetics, and f....
- Dec 14，2023
9001-00-7(Bromelain)Related Search:
1of4
chevron_right