Tetracycline hydrochloride
- CAS No.
- 64-75-5
- Chemical Name:
- Tetracycline hydrochloride
- Synonyms
- TETRACYCLINE HCL;sumycin;cyclopar;tetrachel;topicycline;cancycline-250;Tetracyclin HCl;amycin,hydrochloride;ACHROMYCIN HYDROCHLORIDE;alatet
- CBNumber:
- CB1704886
- Molecular Formula:
- C22H25ClN2O8
- Molecular Weight:
- 480.9
- MOL File:
- 64-75-5.mol
- Modify Date:
- 2024/6/4 15:29:52
| Melting point | 220-223 °C(lit.) |
|---|---|
| alpha | -252 º (c=0.5, H2O) |
| refractive index | -253 ° (C=0.5, 0.1mol/L HCl) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | H2O: 10 mg/mL as a stock solution. Stock solutions should be filtered sterilized and stored at −20°C. Stable at 37°C for 4 days. |
| form | powder |
| color | faint yellow to yellow |
| PH | pH(10g/l, 25℃) : 1.8～3.0 |
| optical activity | [α]/D -255 to 240° (Specific rotation ) |
| Water Solubility | 50 g/L |
| Sensitive | Air & Light Sensitive |
| Merck | 14,9196 |
| BRN | 3844873 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | XMEVHPAGJVLHIG-FMZCEJRJSA-N |
| CAS DataBase Reference | 64-75-5(CAS DataBase Reference) |
| EPA Substance Registry System | Tetracycline hydrochloride (64-75-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335-H361fd-H410 | |||||||||
| Precautionary statements | P202-P261-P273-P302+P352-P305+P351+P338-P308+P313 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | QI9100000 | |||||||||
| F | 8-10-23 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 3 | |||||||||
| HS Code | 29413000 | |||||||||
| Toxicity | LD50 orally in rats: 6443 mg/kg (Goldenthal) | |||||||||
| NFPA 704 |
|
Tetracycline hydrochloride price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | T8032 | Tetracycline hydrochloride powder | 64-75-5 | 10MG | ₹2316.55 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T8032 | Tetracycline hydrochloride powder | 64-75-5 | 20MG | ₹4297.53 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T7660 | Tetracycline hydrochloride powder, BioReagent, suitable for cell culture | 64-75-5 | 5G | ₹4070.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T7660 | Tetracycline hydrochloride powder, BioReagent, suitable for cell culture | 64-75-5 | 25G | ₹11485.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T4062 | Tetracycline hydrochloride meets USP testing specifications | 64-75-5 | 1G | ₹1688.7 | 2022-06-14 | Buy |
Tetracycline hydrochloride Chemical Properties,Uses,Production
Description
Tetracycline is a broad-
Chemical Properties
Yellow crystalline powder
Uses
Tetracycline hydrochloride is a salt prepared from tetracycline taking advantage of the basic dimethylamino group which protonates and readily forms the salt in hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Tetracycline hydrochloride has broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-unit,s blocking protein synthesis.
General Description
Crystals or fine bright yellow powder. pH of 2% aqueous solution: 2.1 - 2.3.
Air & Water Reactions
Water soluble.
Reactivity Profile
Tetracycline hydrochloride is acidic. Reacts with strong oxidizing agents .
Fire Hazard
Flash point data concerning Tetracycline hydrochloride are not available, however, Tetracycline hydrochloride is probably combustible.
Safety Profile
Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. Human systemic effects: change in taste function. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of HCl and NOx. See also TETRACYCLINE.
Purification Methods
The hydrochloride is recrystallised from MeOH/n-BuOH or n-BuOH/HCl. It is insoluble in Et2O and pet ether. It has UV max at 270 and 366nm in MeOH. [Gottstein et al. J Am Chem Soc 81 1198 1959, Conover et al. J Am Chem Soc 84 3222 1962, Stephen et al. J Am Chem Soc 78 4155 1956, Beilstein 14 IV 2627.]
Tetracycline hydrochloride Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CHEMXTREE STANDARDS | +919872732255 | Punjab, India | 96 | 58 | Inquiry |
| Vardhaman P Golechha | 9704422000 | Telangana, India | 294 | 58 | Inquiry |
| Humble Healthcare Limited | +91-9720093000 +91-8006400378 | Uttar Pradesh, India | 141 | 58 | Inquiry |
| Medi Pharma Drug House | +919930911911 | Mumbai, India | 143 | 58 | Inquiry |
| Century Pharmaceuticals Ltd | +91-2652361581 +91-2652361581 | Gujarat, India | 53 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| CHEMXTREE STANDARDS | 58 |
| Vardhaman P Golechha | 58 |
| Humble Healthcare Limited | 58 |
| Medi Pharma Drug House | 58 |
| Century Pharmaceuticals Ltd | 58 |
| SynZeal Research Pvt Ltd | 58 |
| Pharma Affiliates | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| A.J Chemicals | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
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