ChemicalBook > Product Catalog >API >Synthetic Anti-infective Drugs >Quinolones >TROVAFLOXACIN

TROVAFLOXACIN

CAS No.: 147059-72-1

Chemical Name:: TROVAFLOXACIN

Synonyms: CP-99219;TROVAFLOXACIN;Trovan：CP-99219-27;TROVAFLOXACIN USP/EP/BP;Trovafloxacin (CP-99219);7-[(1R,5S)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid;7-[(1R,5S)-6-azanyl-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid;7-[(1R,5S)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-keto-1,8-naphthyridine-3-carboxylic acid;(1α，5α，6α)-7-(6-Amino-3-azabi-cyclo[3.1.0]hex-3-y1)-1-(2，4-difluomphenyl)-6-fluom-1，4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid;1,8-Naphthyridine-3-carboxylic acid, 7-[(1α,5α,6α)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-

CBNumber:: CB1777404

Molecular Formula:: C20H15F3N4O3

Molecular Weight:: 416.36

MOL File:: 147059-72-1.mol

MSDS File:: SDS

Modify Date:: 2023/9/20 16:43:00

Request For Quotation

TROVAFLOXACIN Properties

Melting point	>195oC (dec.)
Boiling point	630.5±55.0 °C(Predicted)
Density	1.612±0.06 g/cm3(Predicted)
storage temp.	-20°C Freezer, Under inert atmosphere
solubility	Acetonitrile (Slightly), DMSO (Slightly)
pka	5.80±0.70(Predicted)
form	Solid
color	Pale Beige to Light Beige
CAS DataBase Reference	147059-72-1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

TROVAFLOXACIN Chemical Properties,Uses,Production

Uses

Trovafloxacin is a fluroquinolone antibiotic, recently identified as an inhibitor of pannexin-1 (Panx1) channels. Trovafloxacin attenuates neuroinflammation and improves outcome after traumatic brain injury in mice.

Definition

ChEBI: A 1,8-naphthyridine derivative that is 4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid bearing additional 2,4-difluorophenyl, fluoro and 6-amino-3-azabicyclo[3.1.0]hex-3-yl substituents at positions 1, 6 and 7 respectively. A broad-spectrum antibiot c that was withdrawn from the market due to risk of liver failure.

TROVAFLOXACIN Preparation Products And Raw materials

Raw materials

1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester Methanesulfonic acid 3-Quinolinecarboxylic acid Dichlorodifluoromethane and difluoroethane azeotropic mixture Aza

NAPHTHYRIDINE-3-CARBOXYLIC ACID Bromonitromethane 1,2-Dimethyl-1,4,5,6-tetrahydropyrimidine (4R,6R)-tert-Butyl-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-4-acetate N-Benzylmaleimide

chevron_left

1of2

chevron_right

Preparation Products

TROVAFLOXACIN Suppliers

Global( 67)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	China	30250	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	23499	58	Inquiry
AFINE CHEMICALS LIMITED	+86-0571-85134551	China	15373	58	Inquiry
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	China	10522	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6393	58	Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	China	8474	58	Inquiry
LEAPCHEM CO., LTD.	+86-852-30606658	China	43348	58	Inquiry

Supplier	Advantage
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Pharma Affiliates	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
LEAPCHEM CO., LTD.	58

TROVAFLOXACIN Spectrum

TROVAFLOXACIN(147059-72-1)¹HNMR

147059-72-1(TROVAFLOXACIN)Related Search:

Clinafloxacin Sparfloxacin Gemifioxacin Gatifloxacin Moxifloxacin

Balofloxacin Pazufloxacin Tosufloxacin Sparfloxacin Alatrofloxacin

3-Fluoro-5-methylpyridine 3-FLUORO-5-FORMYLPYRIDINE 6-PIPERIDIN-1-YLNICOTINALDEHYDE 3-azabicyclo[3.1.0]hexane 2-Amino-5-fluoropyridine

6-(1-PYRROLIDINYL)NICOTINALDEHYDE 2-Amino-3-fluoropyridine 2-Amino-3-acetylpyridine

chevron_left

1of4

chevron_right

TROVAFLOXACIN 1,8-Naphthyridine-3-carboxylic acid, 7-(1.alpha.,5.alpha.,6.alpha.)-6-amino-3-azabicyclo3.1.0hex-3-yl-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo- (1α，5α，6α)-7-(6-Amino-3-azabi-cyclo[3.1.0]hex-3-y1)-1-(2，4-difluomphenyl)-6-fluom-1，4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid CP-99219 Trovan：CP-99219-27 7-[(1R,5S)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-keto-1,8-naphthyridine-3-carboxylic acid 7-[(1R,5S)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid 7-[(1R,5S)-6-azanyl-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid 1,8-Naphthyridine-3-carboxylic acid, 7-[(1α,5α,6α)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo- TROVAFLOXACIN USP/EP/BP Trovafloxacin (CP-99219) NF-κB,inhibit,Topoisomerase,PANX1,DNA,gyrase,Antibiotic,LPS,pro-inflammatory,hepatotoxicity,topoisomerase-IV,Inhibitor,pneumococci,Trovafloxacin,Bacterial,broad-spectrum,TNF rel-7-((1R,5S,6s)-6-Amino-3-azabicyclo[3.1.0]hexan-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid 147059-72-1 C20H15F3N4O3 API