Bromonitromethane
- CAS No.
- 563-70-2
- Chemical Name:
- Bromonitromethane
- Synonyms
- 255858_ALDRICH;EINECS 209-258-0;bromonitro-methan;nitrobromomethane;BROMONITROMETHANE;Nitromethyl bromide;Methane, bromonitro-;Bromonitromethane, tech.;bromonitromethane CH2BrNO2;Bromonitromethane, 90%,tech.
- CBNumber:
- CB7381067
- Molecular Formula:
- CH2BrNO2
- Molecular Weight:
- 139.94
- MOL File:
- 563-70-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/15 10:43:51
| Melting point | -28 °C |
|---|---|
| Boiling point | 146-148 °C/750 mmHg (lit.) |
| Density | 2.007 g/mL at 25 °C (lit.) |
| refractive index | 1.485-1.495 |
| Flash point | 4°C |
| solubility | Chloroform (Soluble), DMSO (Sparingly), Ethyl Acetate (Slightly), Methanol (Slig |
| pka | 7.22±0.29(Predicted) |
| form | Liquid |
| color | Clear yellow |
| Stability | Light Sensitive, Volatile |
| CAS DataBase Reference | 563-70-2(CAS DataBase Reference) |
| EPA Substance Registry System | Methane, bromonitro- (563-70-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS03,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H272-H315-H319-H335 |
| Precautionary statements | P210-P302+P352-P305+P351+P338 |
| Hazard Codes | Xn-O,Xi,O |
| Risk Statements | 8-36/37/38-20/21/22 |
| Safety Statements | 36/37/39-26-17-36 |
| RIDADR | 3098 |
| WGK Germany | 3 |
| RTECS | PA5360000 |
| HazardClass | 5.1 |
| PackingGroup | III |
| HS Code | 29049095 |
Bromonitromethane price More Price(2)
Bromonitromethane Chemical Properties,Uses,Production
Chemical Properties
Bromonitromethane is a clear yellow liquid, It is a strong oxidizing agent with properties similar to nitromethane.
Bromonitromethane has been used:
in production of various protected α-bromo nitroalkane donors (including Fmoc) for use in Umpolung amide synthesis.
in preparation of (Z)-1-bromo-1-nitroalkenes via sodium iodide-catalyzed Henry reaction.
in diastereo- and enantioselective cyclopropanation of β,γ-unsaturated a-ketoesters via domino Michael-addition/intramolecular-alkylation strategy.
Uses
Bromonitromethane has received considerable attention as a one-carbon synthon for the synthesis of a variety of important organic intermediates.
Bromonitromethane is a key starting material for the preparation of the broad-spectrum antibiotic trovafloxacin, which contains the interesting 3-azabicyclo[ 3.1.0]hexane ring system.
it was used in the synthesis of 2-nitrobenzofuran and 2-nitro-2,3-dihydrobenzofuran-3-ols, nitrobenzothio-phenes, and nitrothiazoles, polyfunctionalized nitrocyclopropanes. It has also been utilized in the synthesis of 1-bromo-1-nitroalkan-2-ols and aryl nitromethanes. In addition, it could be used as a bromine donor.
Preparation
Bromonitromethane is commercially available and can also be easily prepared according to the procedures reported by Fishwick et al. A typical procedure is as following: freshly distilled nitromethane was stirred at 0℃ and bromine was dropped in 5 seconds. The resulted bromonitromethane could be used without further purification.
Bromonitromethane Preparation Products And Raw materials
Raw materials
Preparation Products
Bromonitromethane Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Dr. Reddy's Laboratories Ltd. | +91-40-23731946/47/48/49/50 | New Delhi, India | 82 | 82 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29888 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49392 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | China | 34571 | 58 | Inquiry |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | China | 23556 | 58 | Inquiry |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | China | 15395 | 58 | Inquiry |