Bronopol
- CAS No.
- 52-51-7
- Chemical Name:
- Bronopol
- Synonyms
- 2-BROMO-2-NITRO-1,3-PROPANEDIOL;2-BROMO-2-NITROPROPANE-1,3-DIOL;Broponol;Bronopol 1g [52-51-7];2-BroMo-2-nitropropane-1;2-Bromo-2-nitro-1,3-propanedio;2-Nitro-2-bromo-1,3-propanediol;1,3-Propanediol, 2-bromo-2-nitro-;Bronopol(2-BroMo-2-nitro-1,3-propanedio1);2-BROMO-2-NITROPROPANE-1,3-DIOL (BRONOPOL)
- CBNumber:
- CB8375786
- Molecular Formula:
- C3H6BrNO4
- Molecular Weight:
- 199.99
- MOL File:
- 52-51-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/24 17:31:20
| Melting point | 130-133 °C(lit.) |
|---|---|
| Boiling point | 358.0±42.0 °C(Predicted) |
| Density | 2.0002 (rough estimate) |
| refractive index | 1.6200 (estimate) |
| Flash point | 167°C |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | H2O: soluble100mg/mL, clear, colorless to faintly yellow |
| form | Crystals or Crystalline Powder |
| pka | 12.02±0.10(Predicted) |
| color | White to yellow |
| Odor | odorless |
| Water Solubility | 25 g/100 mL (22 ºC) |
| Merck | 14,1447 |
| BRN | 1705868 |
| Stability | Stable. Hygroscopic. Incompatible with strong oxidizing agents, strong bases, strong reducing agents, acid chlorides and anhydrides, moisture. |
| LogP | 1.150 (est) |
| CAS DataBase Reference | 52-51-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Bronopol(52-51-7) |
| EPA Substance Registry System | Bronopol (52-51-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302+H312-H315-H318-H335-H410 | |||||||||
| Precautionary statements | P261-P273-P280-P301+P312-P302+P352+P312-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,N | |||||||||
| Risk Statements | 21/22-37/38-41-50 | |||||||||
| Safety Statements | 26-37/39-61-36/37/39 | |||||||||
| RIDADR | UN 3241 4.1/PG 3 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | TY3385000 | |||||||||
| F | 4.2-8-9-21 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 4.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29055999 | |||||||||
| Toxicity | LD50 in mice, rats (mg/kg): 350, 400 orally (Croshaw) | |||||||||
| NFPA 704 |
|
Bronopol price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemicals (India) | B1247 | 2-Bromo-2-nitro-1,3-propanediol min. 98.0 % | 52-51-7 | 25G | ₹2400 | 2022-05-26 | Buy |
| TCI Chemicals (India) | B1247 | 2-Bromo-2-nitro-1,3-propanediol min. 98.0 % | 52-51-7 | 100G | ₹5500 | 2022-05-26 | Buy |
| TCI Chemicals (India) | B1247 | 2-Bromo-2-nitro-1,3-propanediol min. 98.0 % | 52-51-7 | 500G | ₹7400 | 2022-05-26 | Buy |
| ottokemi | B 2240 | Bronopol 98% | 52-51-7 | 100gm | ₹585 | 2022-05-26 | Buy |
| ottokemi | B 2240 | Bronopol 98% | 52-51-7 | 250gm | ₹1269 | 2022-05-26 | Buy |
Bronopol Chemical Properties,Uses,Production
Description
Bronopol, a formaldehyde releaser, was reported as an allergen in dairy workers. In a recent case report, bronopol was contained in a lubricant jelly used for ultrasound examination and caused contact dermatitis in a veterinary surgeon.
Chemical Properties
Bronopol is a white or almost white crystalline powder; odorless or with a faint characteristic odor.
Uses
First synthesized in 1897, bronopol was primarily used as an effective preservative agent and possesses a wide spectrum of antibacterial activity and inhibits the growth of fungi and yeasts. It can be used in the formulation of a wide variety of cosmetic and personal care products, especially in leave-on and rinse-off shampoos, creams, lotions, rinses and eye makeup to protect the product integrity by preventing or slowing bacterial growth.
Bronopol is used as a microbiocide/microbiostat in oil field systems, air washer systems, air conditioning/humidifying systems, cooling water systems, papermills, absorbent clays, metal working fluids, printing inks, paints, adhesives and consumer/institutional products. A formulating technical material is also registered.
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https://www3.epa.gov
Production Methods
Bronopol is synthesized by the reaction of nitromethane with paraformaldehyde in an alkaline environment, followed by bromination. After crystallization, bronopol powder may be milled to produce a powder of the required fineness.
General Description
White crystals. Ignite easily and burn readily. May detonate under strong shock. Decomposes when heated, evolving toxic gases. Toxic by skin absorption, inhalation or ingestion.
Air & Water Reactions
Highly flammable. Water soluble.
Reactivity Profile
Incompatible with strong oxidizing agents, strong bases, strong reducing agents, acid chlorides and acid anhydrides. 2-Bromo-2-nitro-1,3-propanediol is also incompatible with sulfhydryl compounds or with aluminum or iron containers (it is stable in contact with tin or stainless steel).
Hazard
Toxic by all routes of exposure; skin irritant.
Health Hazard
Fire may produce irritating and/or toxic gases. Contact may cause burns to skin and eyes. Contact with molten substance may cause severe burns to skin and eyes. Runoff from fire control may cause pollution.
Fire Hazard
Flammable/combustible material. May be ignited by friction, heat, sparks or flames. Some may burn rapidly with flare burning effect. Powders, dusts, shavings, borings, turnings or cuttings may explode or burn with explosive violence. Substance may be transported in a molten form at a temperature that may be above its flash point. May re-ignite after fire is extinguished.
Pharmaceutical Applications
Bronopol 0.01–0.1% w/v is used as an antimicrobial preservative either alone or in combination with other preservatives in topical pharmaceutical formulations, cosmetics, and toiletries; the usual concentration is 0.02% w/v.
Contact allergens
Bronopol is a preservative sometimes considered as a formaldehyde releaser. It was reported to be an allergen in cosmetics, cleaning agents, dairy workers, and a lubricant jelly used for ultrasound examination.
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Safety Profile
Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by skin contact. An eye and human skin irritant. An antiseptic. When heated to decomposition it emits very toxic fumes of NOx, and Br-.
storage
Bronopol is stable and its antimicrobial activity is practically
unaffected when stored as a solid at room temperature and ambient
relative humidity for up to 2 years.
The pH of a 1.0% w/v aqueous solution is 5.0–6.0 and falls
slowly during storage; solutions are more stable in acid conditions.
Microbiological assay results indicate longer half-lives than
those obtained by HPLC and thus suggest that degradation
products may contribute to antimicrobial activity. Formaldehyde
and nitrites are among the decomposition products, but formaldehyde
arises in such low concentrations that its antimicrobial effect is
not likely to be significant. On exposure to light, especially under
alkaline conditions, solutions become yellow or brown-colored but
the degree of discoloration does not directly correlate with loss of
antimicrobial activity.
The bulk material should be stored in a well-closed, nonaluminum
container protected from light, in a cool, dry place.
Incompatibilities
Sulfhydryl compounds cause significant reductions in the activity of bronopol, and cysteine hydrochloride may be used as the deactivating agent in preservative efficacy tests; lecithin/polysorbate combinations are unsuitable for this purpose. Bronopol is incompatible with sodium thiosulfate, with sodium metabisulfite, and with amine oxide or protein hydrolysate surfactants. Owing to an incompatibility with aluminum, the use of aluminum in the packaging of products that contain bronopol should be avoided.
Regulatory Status
Included in topical pharmaceutical formulations licensed in Europe. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Bronopol Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| MAISURIYA PHARMA SOLUTIONS | +91 9870085570 | Gujarat, India | 65 | 58 | Inquiry |
| SynthoCascade Research Laboratories | +91-9440962500 +91-9440962500 | Telangana, India | 284 | 58 | Inquiry |
| Yogi Dye Chem Industries | +91-9821098577 +91-9821098577 | Mumbai, India | 124 | 58 | Inquiry |
| ACME SUJAN CHEMICALS | +91 7588647937 | Maharashtra, India | 90 | 58 | Inquiry |
| PERFECT CHEMICAL | +91-9820465461 +91-9820465461 | Mumbai, India | 391 | 58 | Inquiry |
| Murli Krishna Exports Pvt Ltd | +91-2225631595 +91-2225631594 | New Delhi, India | 185 | 58 | Inquiry |
| Devendra Kirti Pharmachem Pvt Ltd | +91-9326475110 +91-9326475110 | Maharashtra, India | 7 | 58 | Inquiry |
| Kenoor Organics Private Limited | +91-7227026011 +91-7227026012 | Gujarat, India | 29 | 58 | Inquiry |
| Salicylates and Chemicals Pvt. Ltd. | +91-8879630551 +91-8898005838 | Maharashtra, India | 61 | 58 | Inquiry |
| Lords Biotech Inc | +91-9867440367 +91-9867440367 | Maharashtra, India | 15 | 58 | Inquiry |
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