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ChemicalBook > Product Catalog >Biochemical Engineering >Amino Acids and Derivatives >Proline derivatives >cis-4-Hydroxy-D-proline hydrochloride

cis-4-Hydroxy-D-proline hydrochloride

cis-4-Hydroxy-D-proline hydrochloride Structure
CAS No.
77449-94-6
Chemical Name:
cis-4-Hydroxy-D-proline hydrochloride
Synonyms
cis-D-Hyp-OH.HCl;H-D-cis-Hyp-OH.HCL;Cis-4-OH-D-pro-OH·HCl;CIS-4-HYDROXY-D-PROLINE HCL;D-Proline, 4-hydroxy-,hydrochloride;cis-4-Hydroxy-D-proline hydrochloride;cis-4-Hydro×y-D-proline hydrochloride;(2R,4R)-4-hydroxyproline hydrochloride;D-Proline, 4-hydroxy-,hydrochloride (1:1);Cis-4-hydroxy-D-proline monohydrochloride
CBNumber:
CB1947559
Molecular Formula:
C5H10ClNO3
Molecular Weight:
167.5908
MOL File:
77449-94-6.mol
Modify Date:
2024/7/2 8:55:01
Request For Quotation

cis-4-Hydroxy-D-proline hydrochloride Properties

Melting point 114-116 °C
storage temp. Inert atmosphere,Room Temperature
form Solid
color White to off-white
InChI InChI=1/C5H9NO3.ClH/c7-3-1-4(5(8)9)6-2-3;/h3-4,6-7H,1-2H2,(H,8,9);1H/t3-,4-;/s3
InChIKey YEJFFQAGTXBSTI-QYDODFSFNA-N
SMILES C(O)(=O)[C@H]1C[C@@H](O)CN1.[H]Cl |&1:3,5,r|

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H319-H335-H302-H315
Precautionary statements  P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
HS Code  29339900

cis-4-Hydroxy-D-proline hydrochloride Chemical Properties,Uses,Production

Synthesis

A mixture of (2S,4R)-4-hydroxypyrrolidine-2-carboxylicacid(50 mmol, 6550 mg) and Ac2O (250 mmol, 23.5 mL) in AcOH (100 mL) wasstirred at reflux for 6 h. The resulting mixture was concentrated to give thecrude intermediate. The solution of this crude intermediate in 2 N HCl (50 mL)was stirred at reflux for 3 h. Then activated charcoal (1 g) was added, the hotmixture was ltered immediately through a Celite layer. The filtrate was concentrated in vacuo to give the crude intermediate.The crude intermediate was dissolved in acetone and filtered. The residue was washed twice with ether anddried in vacuo to give cis-4-Hydroxy-D-proline hydrochloride as a white solid (7.54 g, 90percent).

cis-4-Hydroxy-D-proline hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

N-CBZ-CIS-4-HYDROXY-D-PROLINE METHYL ESTER

cis-4-Hydroxy-D-proline hydrochloride Suppliers

Global( 156)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Tulasi Labs +91-8106722317 +91-8106722317 Telangana, India 44 58 Inquiry
ARRKEM LIFE SCIENCES PRIVATE LIMITED +91-8148739767 +91-8148739767 Telangana, India 347 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
CHEMSWORTH +91-261-2397244 New Delhi, India 6707 30 Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49403 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29821 58 Inquiry
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd +8613580539051 CHINA 21149 58 Inquiry
Supplier Advantage
Tulasi Labs 58
ARRKEM LIFE SCIENCES PRIVATE LIMITED 58
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
CHEMSWORTH 30
Capot Chemical Co.,Ltd. 60
Chongqing Chemdad Co., Ltd 58
CONIER CHEM AND PHARMA LIMITED 58
career henan chemical co 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 58

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cis-4-Hydroxy-D-proline hydrochloride CIS-4-HYDROXY-D-PROLINE HCL (2R,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid hydrochloride cis-4-Hydroxy-D-proline hydrochloride ((2R,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid hydrochloride) cis-4-Hydro×y-D-proline hydrochloride (2R,4R)-4-hydroxyproline hydrochloride cis-D-Hyp-OH.HCl H-D-cis-Hyp-OH.HCL Cis-4-OH-D-pro-OH·HCl (2R,4R)-4-Hydroxypyrrolidine-2-Carboxylic Acid hydrochlorid D-Proline, 4-hydroxy-,hydrochloride (1:1) Cis-4-hydroxy-D-proline monohydrochloride (2R,4R)-cis-4-hydroxy-D-proline hydrochloride cis-4-Hydroxy-D-proline hydrochloride USP/EP/BP D-Proline, 4-hydroxy-,hydrochloride (4R)-4-Hydroxy-D-proline hydrochloride (1:1) 77449-94-6