TBBZ
- CAS No.
- 577779-57-8
- Chemical Name:
- TBBZ
- Synonyms
- 4,5,6,7-tetrabromo-1H-benzimidazole;1H-Benzimidazole, 4,5,6,7-tetrabromo-;4,5,6,7-tetrabromo-1H-benzo[d]imidazole;4,5,6,7-tetrabromo-1H-benzo[d]imidazole(WXC06733)
- CBNumber:
- CB1972937
- Molecular Formula:
- C7H2Br4N2
- Molecular Weight:
- 433.72
- MOL File:
- 577779-57-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/8 9:02:32
TBBZ price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | T6951 | TBBz ≥98% (HPLC), powder | 577779-57-8 | 5MG | ₹15761.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T6951 | TBBz ≥98% (HPLC), powder | 577779-57-8 | 25MG | ₹63250.48 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 5.05766 | Casein Kinase II Inhibitor XII, TBBz - CAS 577779-57-8 - Calbiochem | 577779-57-8 | 20MG | ₹24770.01 | 2022-06-14 | Buy |
TBBZ Chemical Properties,Uses,Production
Chemical Properties
Light Yellow Solid
Uses
TBBz has been used as a CK2 inhibitor in HeLa cells and rat septal neurons.
Biochem/physiol Actions
TBBz is a cell-permeable Casein Kinase-2 (CK2) inhibitor. CK2 inhibitors, 4,5,6,7-tetrabromobenzotriazole (TBBt, Sigma Cat. # T0826) and rabromobenzimidazole (TBBz), the latter of which was shown to discriminate between different molecular forms of CK2 in yeast. TBBt, with a pK(a) ~5, exists in solution at physiological pH almost exclusively (>99%) as the monoanion; whereas TBBz, with a pKa ~9, is predominantly (>95%) in the neutral form, both of obvious relevance to their modes of binding. In vitro, TBBt inhibits different forms of CK2 with Ki values ranging from 80 to 210 nM. TBBz discriminates better between CK2 forms, with Ki values ranging from 70-510 nM. TBBz is more effective than TBBt in inducing apoptosis and to a lesser degree, necrosis in transformed human cell lines. Dvelopment of shRNA strategies for the selective knockdown of the CK2α and CK2α′ isoforms reinforces the foregoing results, indicating that inhibition of CK2 leads to attenuation of proliferation.
TBBZ Preparation Products And Raw materials
Raw materials
Preparation Products
TBBZ Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | China | 19994 | 58 | Inquiry |
| Shanghai Kaiwei Chemical Technology Co., Ltd. | 021-58461859 15821823057 | China | 49323 | 58 | Inquiry |
| Aikon International Limited | 025-66113011 18112977050 | China | 16028 | 58 | Inquiry |
| DC Chemicals | 021-58447131 13564518121 | China | 9412 | 58 | Inquiry |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 4008210725 4008210725 | China | 55023 | 58 | Inquiry |
| Beijing Stronger Science Co., Ltd. | 0531-88924771 15614660963 | China | 10624 | 58 | Inquiry |
| Henan Lien Chemical Products Co., Ltd. | 15378766539 | China | 4007 | 58 | Inquiry |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | China | 8141 | 58 | Inquiry |
| Suzhou Meishi Biotechnology Co., Ltd. | 1173954148q | China | 20035 | 58 | Inquiry |