OXYPHENYL BUTAZONE
- CAS No.
- 129-20-4
- Chemical Name:
- OXYPHENYL BUTAZONE
- Synonyms
- bm1;BM 1;Flogal;Frabel;g27202;Iridil;Mysite;Neofen;Oxalid;Reumox
- CBNumber:
- CB2133346
- Molecular Formula:
- C19H20N2O3
- Molecular Weight:
- 324.37
- MOL File:
- 129-20-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/3/19 15:37:50
| Melting point | 109-111°C |
|---|---|
| Boiling point | 462.71°C (rough estimate) |
| Density | 1.2118 (rough estimate) |
| refractive index | 1.6140 (estimate) |
| storage temp. | -20°C |
| solubility | DMSO: soluble10mg/mL, clear |
| pka | pKa 4.7/10.0±0.2(H2O,t =25,Iundefined) (Uncertain) |
| form | powder |
| color | white to brown |
| Water Solubility | 20mg/L(room temperature) |
| Stability | Hygroscopic |
| CAS DataBase Reference | 129-20-4(CAS DataBase Reference) |
| IARC | 3 (Vol. 13, Sup 7) 1987 |
| EPA Substance Registry System | 3,5-Pyrazolidinedione, 4-butyl-1-(4-hydroxyphenyl)-2-phenyl- (129-20-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H400 | |||||||||
| Precautionary statements | P273-P301+P312+P330 | |||||||||
| Hazard Codes | Xn,N | |||||||||
| Risk Statements | 22-50 | |||||||||
| Safety Statements | 61 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
OXYPHENYL BUTAZONE price More Price(2)
OXYPHENYL BUTAZONE Chemical Properties,Uses,Production
Chemical Properties
Light Beige Solid
Uses
Anti-inflammatory;Cyclooxygenase inhibito
Indications
Oxyphenbutazone (Oxalid, Tandearil) is the principal uricosuric metabolite of phenylbutazone. It has the same indications and toxicities as phenylbutazone.
Definition
ChEBI: A metabolite of phenylbutazone obtained by hydroxylation at position 4 of one of the phenyl rings. Commonly used (as its hydrate) to treat pain, swelling and stiffness associated with arthritis and gout, it was withdrawn from the market 1984 following asso iation with blood dyscrasis and Stevens-Johnson syndrome.
World Health Organization (WHO)
Oxyphenbutazone, a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, was introduced in 1955 for the treatment of rheumatic disorders. It is one of the active metabolites of phenylbutazone and has a similar spectrum of activity including an association with serious and sometimes fatal adverse reactions, notably cases of aplastic anaemia and agranulocytosis. Many national drug regulatory authorities consider that more recently introduced drugs offer a safer alternative for most, if not all, patients requiring antiinflammatory agents. Although oxyphenbutazone has been widely withdrawn it remains available in some countries.
General Description
Oxyphenbutazone is a derivative compound of phenylbutazone. Oxyphenbutazone is one of the metabolites formed in the liver following administration of phenylbutazone. Given orally it causes fewer gastrointestinal adverse effects than phenylbutazone and is used at 300 – 400 mg/d for the same indications as the parent drug.
OXYPHENYL BUTAZONE Preparation Products And Raw materials
OXYPHENYL BUTAZONE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
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| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | China | 52861 | 58 | Inquiry |
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