PHYSOSTIGMINE SALICYLATE
- CAS No.
- 57-64-7
- Chemical Name:
- PHYSOSTIGMINE SALICYLATE
- Synonyms
- ESERINE SALICYLATE;Physostigmine-d3 salicylate;ar-44;tl-1380;CCRIS 3405;Isopto Eserine;EINECS 200-343-8;physostolsalicylate;Physostigminsalicylat;ESERINE SALICYLATE(RG)
- CBNumber:
- CB2146890
- Molecular Formula:
- C22H27N3O5
- Molecular Weight:
- 413.47
- MOL File:
- 57-64-7.mol
- Modify Date:
- 2024/7/2 8:55:03
| Melting point | 181-183 °C |
|---|---|
| storage temp. | -20°C |
| solubility | DMF: 30 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 1 mg/ml |
| pka | pKa 1.96/8.08(H2O,t =15) (Uncertain) |
| form | Solid |
| color | White to yellow |
| Merck | 7384 |
| BRN | 3900576 |
| InChIKey | HZOTZTANVBDFOF-DPKVYHSMNA-N |
| SMILES | C12C=C(C=CC=1N(C)[C@@]1([H])N(CC[C@@]21C)C)OC(=O)NC.C1(C(=O)O)=CC=CC=C1O |&1:8,13,r| |
| CAS DataBase Reference | 57-64-7(CAS DataBase Reference) |
| EPA Substance Registry System | Physostigmine salicylate (57-64-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300+H330 | |||||||||
| Precautionary statements | P301+P310+P330-P304+P340+P310 | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 26/28 | |||||||||
| Safety Statements | 25-45 | |||||||||
| RIDADR | UN 1544 6.1/PG 1 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TJ2450000 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 2939800000 | |||||||||
| Toxicity | LD50 i.p. in mice: 0.64 mg/kg (Sofia, Knabloch) | |||||||||
| NFPA 704 |
|
PHYSOSTIGMINE SALICYLATE Chemical Properties,Uses,Production
Chemical Properties
solid
Uses
Physostigmine salicylate (Eserine salicylate) is used as bulk pharmaceuticals (parasympathomimetic, cholinergic, ophthalmic, anti-Alzheimer). Product Data Sheet
General Description
The salicylate ofphysostigmine (eserine salicylate) may be prepared byneutralizing an ethereal solution of the alkaloid with anethereal solution of salicylic acid. Excess salicylic acid isremoved from the precipitated product by washing itwith ether. The salicylate is less deliquescent than thesulfate.
Physostigmine salicylate occurs as a white, shining,odorless crystal or white powder that is soluble in water(1:75), alcohol (1:16), or chloroform (1:6) but much lesssoluble in ether (1:250). On prolonged exposure to air andlight, the crystals turn red. The red may be removed bywashing the crystals with alcohol, although this causes lossof the compound as well. Aqueous solutions are neutral orslightly acidic and take on a red coloration after a period.The coloration may be taken as an index of the loss of activityof physostigmine solutions.
Reactivity Profile
Behaves as a weak acid in solution.
Health Hazard
PHYSOSTIGMINE SALICYLATE is similar to physostigmine. It is classified as super toxic. The probable oral lethal dose (humans) is less than 5 mg/kg or a taste for a 150 lb. person. It is a cholinesterase inhibitor.
Fire Hazard
When heated to decomposition, PHYSOSTIGMINE SALICYLATE emits toxic fumes of nitrogen oxides.
Safety Profile
Poison by ingestion, subcutaneous, intramuscular, intravenous, and intraperitoneal routes. Human systemic effects: arrhythmias, nausea or vomiting. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx See also PHYSOSTIGMINE.
PHYSOSTIGMINE SALICYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Neugen Labs | +91-8133254502 +91-8133254502 | Karnataka, India | 195 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | China | 8474 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21676 | 55 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| Kindchem(Nanjing)Co.,Ltd | +86-025-025-85281586 +8618651653755 | China | 1227 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Dorne Chemical Technology co. LTD | +86-86-13583358881 +8618560316533 | China | 3148 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 26216 | 58 | Inquiry |
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