PHYSOSTIGMINE SALICYLATE
PHYSOSTIGMINE SALICYLATE
- CAS:
- 57-64-7
- MF:
- C22H27N3O5
- MW:
- 413.47
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Properties
- Melting point:
- 181-183 °C
- storage temp.
- -20°C
- solubility
- DMF: 30 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 1 mg/ml
- pka
- pKa 1.96/8.08(H2O,t =15) (Uncertain)
- form
- Solid
- color
- White to yellow
- Merck
- 7384
- BRN
- 3900576
- InChIKey
- HZOTZTANVBDFOF-DPKVYHSMNA-N
- SMILES
- C12C=C(C=CC=1N(C)[C@@]1([H])N(CC[C@@]21C)C)OC(=O)NC.C1(C(=O)O)=CC=CC=C1O |&1:8,13,r|
Safety Information
- Symbol(GHS)
GHS06
- Signal word
- Danger
- Hazard statements
- H300+H330
- Precautionary statements
- P301+P310+P330-P304+P340+P310
- Hazard Codes
- T+
- Risk Statements
- 26/28
- Safety Statements
- 25-45
- RIDADR
- UN 1544 6.1/PG 1
- WGK Germany
- 3
- RTECS
- TJ2450000
- HazardClass
- 6.1(a)
- PackingGroup
- II
- HS Code
- 2939800000
- Toxicity
- LD50 i.p. in mice: 0.64 mg/kg (Sofia, Knabloch)
Use
The salicylate ofphysostigmine (eserine salicylate) may be prepared byneutralizing an ethereal solution of the alkaloid with anethereal solution of salicylic acid. Excess salicylic acid isremoved from the precipitated product by washing itwith ether. The salicylate is less deliquescent than thesulfate.Physostigmine salicylate occurs as a white, shining,odorless crystal or white powder that is soluble in water(1:75), alcohol (1:16), or chloroform (1:6) but much lesssoluble in ether (1:250). On prolonged exposure to air andlight, the crystals turn red. The red may be removed bywashing the crystals with alcohol, although this causes lossof the compound as well. Aqueous solutions are neutral orslightly acidic and take on a red coloration after a period.The coloration may be taken as an index of the loss of activityof physostigmine solutions.
2 India supplier list of "PHYSOSTIGMINE SALICYLATE"
- Product Name:Physostigmine salicylate
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:PhysostigmineSalicylate
- Products Intro:Brand:pharmaffiliates | Product Number:PA6942000
- Company Type: Trader
- Country/Region: INDIA
$1.10/ 1g
- Product Name:PHYSOSTIGMINE SALICYLATE
- Products Intro:Purity: 99.9%|Package: 1g;1.1USD
- Company Type: Trader
- Country/Region: CHINA