PHYSOSTIGMINE SALICYLATE manufacturers and suppliers in india

PHYSOSTIGMINE SALICYLATE

Properties

Melting point:: 181-183 °C

storage temp.: -20°C

solubility: DMF: 30 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 1 mg/ml

pka: pKa 1.96/8.08(H2O,t =15) (Uncertain)

form: Solid

color: White to yellow

Merck: 7384

BRN: 3900576

InChIKey: HZOTZTANVBDFOF-DPKVYHSMNA-N

SMILES: C12C=C(C=CC=1N(C)[C@@]1([H])N(CC[C@@]21C)C)OC(=O)NC.C1(C(=O)O)=CC=CC=C1O |&1:8,13,r|

Safety Information

Symbol(GHS): GHS06

Signal word: Danger

Hazard statements: H300+H330

Precautionary statements: P301+P310+P330-P304+P340+P310

Hazard Codes: T+

Risk Statements: 26/28

Safety Statements: 25-45

RIDADR: UN 1544 6.1/PG 1

WGK Germany: 3

RTECS: TJ2450000

HazardClass: 6.1(a)

PackingGroup: II

HS Code: 2939800000

Toxicity: LD50 i.p. in mice: 0.64 mg/kg (Sofia, Knabloch)

Use

The salicylate ofphysostigmine (eserine salicylate) may be prepared byneutralizing an ethereal solution of the alkaloid with anethereal solution of salicylic acid. Excess salicylic acid isremoved from the precipitated product by washing itwith ether. The salicylate is less deliquescent than thesulfate.Physostigmine salicylate occurs as a white, shining,odorless crystal or white powder that is soluble in water(1:75), alcohol (1:16), or chloroform (1:6) but much lesssoluble in ether (1:250). On prolonged exposure to air andlight, the crystals turn red. The red may be removed bywashing the crystals with alcohol, although this causes lossof the compound as well. Aqueous solutions are neutral orslightly acidic and take on a red coloration after a period.The coloration may be taken as an index of the loss of activityof physostigmine solutions.