5,7-Diiodo-8-quinolinol
- CAS No.
- 83-73-8
- Chemical Name:
- 5,7-Diiodo-8-quinolinol
- Synonyms
- IODOQUINOL;DIIODOHYDROXYQUINOLINE;DIIODOHYDROXYQUIN;5,7-DIIODO-8-HYDROXYQUINOLINE;ss578;Dyodin;Ioquin;SS 578;Yodoxin;Zoaquin
- CBNumber:
- CB2170413
- Molecular Formula:
- C9H5I2NO
- Molecular Weight:
- 396.95
- MOL File:
- 83-73-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/18 11:31:05
| Melting point | >200 °C (dec.) (lit.) |
|---|---|
| Boiling point | 370.95°C (rough estimate) |
| Density | 2.3013 (estimate) |
| storage temp. | Refrigerator |
| solubility | DMSO (Slightly, Heated), Ethyl Acetate (Slightly, Heated) |
| form | Solid |
| pka | pKa 8.0 (Uncertain) |
| color | Pale Yellow to Light Beige |
| Water Solubility | 1g/L at 26℃ |
| Merck | 14,5042 |
| InChIKey | UXZFQZANDVDGMM-UHFFFAOYSA-N |
| LogP | 0.602 at 26℃ |
| CAS DataBase Reference | 83-73-8(CAS DataBase Reference) |
| NIST Chemistry Reference | 5,7-Diiodo-8-hydroxyquinoline(83-73-8) |
| EPA Substance Registry System | 5,7-Diiodo-8-quinolinol (83-73-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H318 |
| Precautionary statements | P280-P301+P312+P330-P305+P351+P338+P310 |
| Hazard Codes | Xn |
| Risk Statements | 22-41 |
| Safety Statements | 26-36/37/39 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| RTECS | VC5775000 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 29334900 |
| Toxicity | LD50 intravenous in mouse: 56mg/kg |
5,7-Diiodo-8-quinolinol Chemical Properties,Uses,Production
Indications
Iodoquinol (diiodohydroxyquin, Yodoxin, Moebiquin)
is a halogenated 8-hydroxyquinoline derivative whose
precise mechanism of action is not known but is thought
to involve an inactivation of essential parasite enzymes.
Iodoquinol kills the trophozoite forms of E. histolytica,
B. coli, B. hominis, and Dientamoeba fragilis.
Iodoquinol is absorbed from the gastrointestinal
tract and is excreted in the urine as glucuronide and sulfate
conjugates. Most of an orally administered dose is
excreted in the feces. Iodoquinol has a plasma half-life
of about 12 hours.
Iodoquinol is the drug of choice in the treatment of
asymptomatic amebiasis and D. fragilis infections. It is
also used in combination with other drugs in the treatment
of other forms of amebiasis and as an alternative
to tetracycline in the treatment of balantidiasis.
Adverse reactions are related to the iodine content
of the drug; the toxicity is often expressed as skin reactions,
thyroid enlargement, and interference with thyroid
function studies. Headache and diarrhea also occur.
Chronic use of clioquinol, a closely related agent,
has been linked to a myelitislike illness and to optic atrophy
with permanent loss of vision.
Clinical Use
5,7-Diiodo-8-quinolinol, 5,7-diiodo-8-hydroxyquinoline,or diiodohydroxyquin (Yodoxin, Diodoquin, Diquinol) is ayellowish to tan microcrystalline, light-sensitive substancethat is insoluble in water. It is recommended for acute andchronic intestinal amebiasis but is not effective in extraintestinaldisease. Because a relatively high incidence of topicneuropathy has occurred with its use, iodoquinol should notbe used routinely for traveler’s diarrhea.
Safety Profile
Poison by ingestion and intravenous routes. Human systemic effects by ingestion: eye effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of Iand Nox
Purification Methods
It crystallises from xylene and is dried at 70o in a vacuum. [Beilstein 21 II 58.]
5,7-Diiodo-8-quinolinol Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| BTC pharm India | +918790379245 | AndhraPradesh, India | 1269 | 58 | Inquiry |
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| Eskay Iodine Pvt Ltd | +91-22-6622 7575 | Mumbai, India | 28 | 58 | Inquiry |
| Prayag Pharmachem | +91-9921873418 +91-9921873418 | Maharashtra, India | 16 | 58 | Inquiry |
| Adani Pharmachem Pvt Ltd | +91-7573044087 +91-9974652373 | Gujarat, India | 27 | 58 | Inquiry |
| Gradient Exports | 91-22-66103373 | Maharashtra, India | 77 | 58 | Inquiry |
| Opulent Pharma | 08068441147Ext 981 | Gujarat, India | 810 | 58 | Inquiry |
| DM Pharma | 91-44-28172391 | Tamil Nadu, India | 110 | 58 | Inquiry |
| Gemini Exports | 91-22-24106001 | Maharashtra, India | 140 | 58 | Inquiry |
| Indexim International | 08048971004 | Gujarat, India | 112 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| BTC pharm India | 58 |
| GLR Innovations | 58 |
| Eskay Iodine Pvt Ltd | 58 |
| Prayag Pharmachem | 58 |
| Adani Pharmachem Pvt Ltd | 58 |
| Gradient Exports | 58 |
| Opulent Pharma | 58 |
| DM Pharma | 58 |
| Gemini Exports | 58 |
| Indexim International | 58 |
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