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DMT-2′O-Methyl-rC(ac) Phosphoramidite

CAS No.: 199593-09-4

Chemical Name:: DMT-2′O-Methyl-rC(ac) Phosphoramidite

Synonyms: (2R,3R,4R,5R)-5-(4-Acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite;Cytidine Impurity 14;2’-OMe -dC(Ac) Amidite;N4-Ac-5'-O-DMT-2'-OMe-C-CE;N4-Ac-5'-O-DMT-2'-OMe-C-CE;2'-OMe-Ac-C Phosphoramidite;Ac-2'-Ome-rC Phosphoramidite;2'-OMe-Ac-C Phosphoramidite;2'-OMe-C(Ac) Phosphoramidite;2'-OMe-N-Ac Cytidine?Amidite

CBNumber:: CB21871625

Molecular Formula:: C42H52N5O9P

Molecular Weight:: 801.86

MOL File:: 199593-09-4.mol

Modify Date:: 2023/5/18 11:31:15

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DMT-2′O-Methyl-rC(ac) Phosphoramidite Properties

Melting point	102 - 104°C
storage temp.	Sealed in dry,2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	powder
pka	10.18±0.20(Predicted)
color	white to off-white
InChIKey	WNWUMIPFLOKTEZ-UAQIPLLRSA-N
SMILES	O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C=CC(NC(C)=O)=NC2=O)[C@H](OC)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N \|&1:25,27,39,42,r\|

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Safety Statements	24/25
WGK Germany	3
HS Code	29349990

DMT-2′O-Methyl-rC(ac) Phosphoramidite price More Price(6)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	C213180	DMT-2′O-Methyl-rC(ac) Phosphoramidite configured for PerkinElmer, configured for Polygen	199593-09-4	1G	₹8508.45	2022-06-14	Buy
Sigma-Aldrich(India)	C213180	DMT-2′O-Methyl-rC(ac) Phosphoramidite configured for PerkinElmer, configured for Polygen	199593-09-4	0.5G	₹8952.28	2022-06-14	Buy
Sigma-Aldrich(India)	C213130	DMT-2′O-Methyl-rC(ac) Phosphoramidite configured for ABI	199593-09-4	1G	₹8118.75	2022-06-14	Buy
Sigma-Aldrich(India)	C213130	DMT-2′O-Methyl-rC(ac) Phosphoramidite configured for ABI	199593-09-4	0.5G	₹8952.28	2022-06-14	Buy
Sigma-Aldrich(India)	C213100	DMT-2′O-Methyl-rC(ac) Phosphoramidite	199593-09-4	100G	₹647086.03	2022-06-14	Buy

Product number	Packaging	Price	Buy
C213180	1G	₹8508.45	Buy
C213180	0.5G	₹8952.28	Buy
C213130	1G	₹8118.75	Buy
C213130	0.5G	₹8952.28	Buy
C213100	100G	₹647086.03	Buy

DMT-2′O-Methyl-rC(ac) Phosphoramidite Chemical Properties,Uses,Production

Uses

2''-OMe-Ac-C Phosphoramidite (CAS# 199593-09-4) is a nucleotide used in the solid-phase synthesis of phosphorothioate oligonucleotides using sulfurization byproducts for in situ capping.

Application

2′O-Methyl RNA nucleoside including DMT-2′O-Methyl-rC(ac) Phosphoramidite can be advantageously incorporated in nucleic acid probes with RNA or DNA for in-vivo or in-vitro applications to convey nuclease resistance.The unique combination of properties of 2′O-Methyl RNA had found widespread use in the fields of:
Diagnostic probes
Aptamer and ribozyme development
Mixed 2′O-Methyl-RNA/DNA antisense molecules

General Description

DMT-2′O-Methyl-rC(ac) Phosphoramidite is one of the 2′O-Methyl RNA monomers that feature methoxy groups at the 2′-position. Themethoxy groups are perfectly stable in all conditions employed in theassembly of oligonucleotides by automated phosphoramidite synthesis, andin all standard alkaline deprotection conditions.Its key features include:
High yield of crude oligonucleotides
Compatible with DNA synthesis
Can be employed together with DNA or RNA phosphoramidites in thesame synthesis to produce mixmer oligonucleotides
Recommended deprotection conditions are 8 hours at 55 °C usingconcentrated ammonia solution, or with AMA (concentrated ammonia/40% aqueous methylamine I/I, v/v) for 10 minutes at 65 °C
Purification and other downstream processing of fully modified 2′OMethyl RNA oligonucleotides are simpler than in the case of RNA, as nospecial precautions are required to provide protection against nucleolyticdegradation
Synthesis of 2′O-Methyl RNA oligonucleotides is similar to standard DNA synthesis but requires an elongated coupling time (recommended is 6minutes compared to 90 seconds for DNA monomers)
2′O-Methyl RNA phosphoramidites are also available with fast deprotection chemistry

DMT-2′O-Methyl-rC(ac) Phosphoramidite Preparation Products And Raw materials

Raw materials

Preparation Products

DMT-2′O-Methyl-rC(ac) Phosphoramidite Suppliers

Global( 159)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Innovassynth Technologies (I) Ltd.	+91-2192260100 +91-7208872197	Maharashtra, India	118	58	Inquiry
Gagri Global IT Services Pvt. Ltd.	+91-40-27170174,	Telangana, India	1321	58	Inquiry
A. B. Enterprises	+91-8048077585	Mumbai, India	1396	58	Inquiry
Wuhu Nuowei chemistry Co., Ltd.	+86-0553-2911116-802 +undefined17756524438	China	1640	58	Inquiry
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	China	16209	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29898	58	Inquiry
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	China	10318	58	Inquiry
Yunbio Tech Co.,Ltd.	+86-010-60605551 +86-18046518538	China	321	58	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry

Supplier	Advantage
Innovassynth Technologies (I) Ltd.	58
Gagri Global IT Services Pvt. Ltd.	58
A. B. Enterprises	58
Wuhu Nuowei chemistry Co., Ltd.	58
Shanghai Daken Advanced Materials Co.,Ltd	58
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Yunbio Tech Co.,Ltd.	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58

199593-09-4(DMT-2′O-Methyl-rC(ac) Phosphoramidite)Related Search:

DMT-2′O-TBDMS-rU Phosphoramidite DMT-2'O-Methyl-rU Phosphoramidite Dmt-2'-f-dc(ac) amidite N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]-6'-O-methylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite DMT-2'O-TBDMS-rA(bz) Phosphoramidite

Ac-rC Phosphoramidite 2’-O-Methyl-rA(N-Bz)phosphoramidite 5'-O-[(N,N-DIISOPROPYLAMINO)-(2-CYANOETHOXY)PHOSPHINYL]-3'-O-(4,4'-DIMETHOXYTRITYL)-THYMIDINE DMT-dG(dmf) Phosphoramidite 2'-OMe-ibu-G Phosphoramidite

Acetyl coenzyme A sodium salt N-ACETYL-L-TYROSINE ETHYL ESTER Acetylacetone Acetylferrocene tributyl acetocitrate

Cytidine DMT-2′O-Methyl-rC(ac) Phosphoramidite Acetyl-resveratrol

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2'-O-Methyl-N4-Acetyl-5'-O-DMT-Cytidine-3'-CE-Phosphoramidite -5-(4-Acetamido-2-oxopyrimidin-1(2H) 2'-OMe-Ac-C Phosphoramidite 2’-O-Methyl-rC(N-Ac)Phosphoramidite 5'-O-DMT-2'-O-Me-rC(N-Ac)-3'-CEDPA N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite 5'-DMT-2'-OMe-rC(N-Ac) Phosphoramidite N4-Acetyl-5'-O-DMT-2'-O-methylcytidine 3'-CE phosphoramidite DMT-2′O-Methyl-rC(ac) Phosphoramidite Ac-2'-Ome-rC Phosphoramidite 2'-OMe-Ac-rC -CE Phosphoramidite N4-acetyl-5'-O-(4, 4'-Dimethoxytrityl)-2'-O-methyl-Cytidine-3'-CE-Phosphoramidite 2'-OMe-Ac-C Phosphoramidite (~90%) Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] 2'-OMe-C(Ac) Phosphoramidite N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite USP/EP/BP 5'-Dimethoxytrityl-N-acetyl-Cytidine,2'-O-methyl,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite N4-ACETYL-5-O-DMTr-2-O-METHYLCYTIDINE-3-O- CE-AMIDITE 5'-O-DMT-2'-OMe-Ac-C-CE-Phosphoramidite (2R,3R,4R,5R)-5-(4-Acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] 5'-O-DMT-N4-Acetyl-2'-O-methylcytidine 3'-CE phosphoramidite 5'-O-DMT-2'-OMe-Acetyl-Cytidine-CE Phosphoramidite DMT-2-O-ME-C-CE Phosphoramidite "DMT-2'-O-Me-dC(Ac) Phosphoramidite" N4-Ac-5'-O-DMT-2'-OMe-C-CE DMT-2’-OMe-C(Ac)-CE Phosphoramidite 2'-OMe-N-Ac Cytidine?Amidite Cytidine Impurity 14 DMTr-2'-O-Me-rC(Ac)-3'-CE-Phosphoramidite 2’-OMe -dC(Ac) Amidite 5'-ODMT-2'-OMe-N-Ac Cytidine-3'-OCEPA 2'-OMe-Ac-C Phosphoramidite DMT-2'-O-Me-C(Ac)-CE Phosphoramidite N4-Ac-5'-O-DMT-2'-OMe-C-CE 5'-O-DMT-2'-OMe-Acetyl-Cytidine-CE Phosphoramidite 2'-OMe-C(Ac)-CE-Phosphoramidite 2'-OMe-Ac-C CE Phosphoramidite N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite 2'-OMe-rC(Ac)Phosphoramidite 199593-09-4 C42H52N5O9P Amidite