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ChemicalBook > Product Catalog >Pharmaceutical intermediates >Bulk Drug Intermediates >DMT-2'O-TBDMS-rA(bz) Phosphoramidite

DMT-2'O-TBDMS-rA(bz) Phosphoramidite

DMT-2'O-TBDMS-rA(bz) Phosphoramidite Structure
CAS No.
104992-55-4
Chemical Name:
DMT-2'O-TBDMS-rA(bz) Phosphoramidite
Synonyms
Bz-rA Phosphoramidite;2'-TBDMS-A CEP;N-Benzoyl-5-O-(4;RNA N-Bz A Amidite;8-Aza-7-deaza-A CEP;DMT-2'-0-TBDMS-rA(BZ);DMT-2'-O-TBDMS-A(Bz)-CE;2’-OTBDMS-rA(Bz) Amidite;N-diisopropyl)phosphoramidite;2TBDMS-rA(BZ) Phosphoramidite
CBNumber:
CB41871629
Molecular Formula:
C53H66N7O8PSi
Molecular Weight:
988.19
MOL File:
104992-55-4.mol
MSDS File:
SDS
Modify Date:
2023/12/13 9:26:12
Request For Quotation

DMT-2'O-TBDMS-rA(bz) Phosphoramidite Properties

storage temp. Inert atmosphere,Store in freezer, under -20°C
form powder
pka 7.87±0.43(Predicted)
color white to off-white
InChIKey FFXHNCNNHASXCT-RFMFGJHUSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338
WGK Germany  3
HS Code  29349990

DMT-2'O-TBDMS-rA(bz) Phosphoramidite price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) A211050 DMT-2′O-TBDMS-rA(bz) Phosphoramidite configured for (?KTA? and OligoPilot?) 104992-55-4 2G ₹16367.4 2022-06-14 Buy
Sigma-Aldrich(India) A211050 DMT-2′O-TBDMS-rA(bz) Phosphoramidite configured for (?KTA? and OligoPilot?) 104992-55-4 5G ₹40182.4 2022-06-14 Buy
Sigma-Aldrich(India) A211050 DMT-2′O-TBDMS-rA(bz) Phosphoramidite configured for (?KTA? and OligoPilot?) 104992-55-4 10G ₹80321.5 2022-06-14 Buy
Sigma-Aldrich(India) A211040 DMT-2′O-TBDMS-rA(bz) Phosphoramidite configured for MerMade 104992-55-4 0.5G ₹9731.68 2022-06-14 Buy
Sigma-Aldrich(India) A211040 DMT-2′O-TBDMS-rA(bz) Phosphoramidite configured for MerMade 104992-55-4 5G ₹42693.8 2022-06-14 Buy
Product number Packaging Price Buy
A211050 2G ₹16367.4 Buy
A211050 5G ₹40182.4 Buy
A211050 10G ₹80321.5 Buy
A211040 0.5G ₹9731.68 Buy
A211040 5G ₹42693.8 Buy

DMT-2'O-TBDMS-rA(bz) Phosphoramidite Chemical Properties,Uses,Production

Uses

N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite can be used as Organic synthesis intermediates and pharmaceutical intermediates are mainly used in laboratory research and development processes and chemical production processes.

Uses

DMT-2''O-TBDMS-rA(bz) Phosphoramidite (DMT-2'O-TBDMS-rA(bz) Phosphoramidite) is a 2''-O-Protected ribonucleoside phosphoramidite used as a key raw material for the automated solid-supported synthesis of oligonucleotide-based drugs. It is also used to synthesize 2''-O-guanidinopropyl-modified nucleoside phosphoramidites to incorporate into siRNAs targeting hepatitis B virus.

Synthesis

Synthesis_104992-55-4
To a solution of 72 (12.0 g, 15.2 mmoi) in DIPEA (15 ml) and DCM (30 mL) is added DMAP (744 mg, 6.09 rnrnol) and 2cyanoethyl JV.Ndiisopropylchlorophosphoramidite (5.41 g, 22.9 rnmoi) at 25 ℃. After stirring for 2 hours, the mixture is purified directly by basic silica gel column chromatography (EAIPE 1/4 toi/1) to give DMT-2'O-TBDMS-rA(bz) Phosphoramidite as a white solid (13.0 g. 86% yield)

DMT-2'O-TBDMS-rA(bz) Phosphoramidite Preparation Products And Raw materials

Raw materials

Preparation Products

DMT-2'O-TBDMS-rA(bz) Phosphoramidite Suppliers

Global( 184)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Innovassynth Technologies (I) Ltd. +91-2192260100 +91-7208872197 Maharashtra, India 118 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
A. B. Enterprises +91-8048077585 Mumbai, India 1396 58 Inquiry
Allbiosyn Biotechnology Co.,Ltd. +8618666985712 China 286 58 Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
Shanghai Daken Advanced Materials Co.,Ltd +86-371-66670886 China 18642 58 Inquiry
Henan Tianfu Chemical Co.,Ltd. +86-0371-55170693 +86-19937530512 China 21667 55 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29888 58 Inquiry
Jinan Carbotang Biotech Co.,Ltd. +8615866703830 China 7621 58 Inquiry
Yunbio Tech Co.,Ltd. +86-010-60605551 +86-18046518538 China 321 58 Inquiry
Supplier Advantage
Innovassynth Technologies (I) Ltd. 58
A.J Chemicals 58
A. B. Enterprises 58
Allbiosyn Biotechnology Co.,Ltd. 58
Capot Chemical Co.,Ltd. 60
Shanghai Daken Advanced Materials Co.,Ltd 58
Henan Tianfu Chemical Co.,Ltd. 55
career henan chemical co 58
Jinan Carbotang Biotech Co.,Ltd. 58
Yunbio Tech Co.,Ltd. 58

104992-55-4(DMT-2'O-TBDMS-rA(bz) Phosphoramidite)Related Search:

BENZOYL ISOCYANATE Buprofezin ADENOSINE 5'-TRIPHOSPHATASE tert-Butanol Benzoyl chloride
Cyhalofop-butyl Benzoyl peroxide Dimethyldimethoxysilane tert-Butyl acetate tert-Butyldimethylsilyl chloride
tert-Butyl peroxyacetate N-Benzoylaminopurine 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYADENOSINE TERT-BUTYLDIMETHYLSILANOL N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine
N6-BENZYLADENOSINE N6-BENZOYL-3'-DEOXYADENOSINE DIMETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE
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DMT-2′O-TBDMS-rA(bz) Phosphoramidite 2'-TBDMS -Bz-rA-CE-Phosphoramidite 5'-DMT-2'-O-TBDMS- N6-Benzoyl-Adenosine Phosphoramidite (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(tert-butyldimethylsilyloxy)tetrahydrofuran-3-yl 2-cyanoethyl diisopropylphosphoramidite REF DUPL: 2'-TBDMS-rA(N-Bz)Phosphoramidite N6-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine 3'-CE phosphoramidite 5'-O-(4,4'-DiMethoxy)-N6-benzoyl-2'-O-(t-butyl diMethylsilyl)adenosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoraMidite 5'-O-DMT-2'-O-TDMS-N6-Bz-Adenosine-3'-CED PhosphoraMidite Adenosine, N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-O-[(1,1-diMethylethyl)diMethylsilyl]-, 3'-[2-cyanoethyl bis(1-Methylethyl)phosphoraMidite] 2’-TBDMS-rA(N-Bz) Phosphoramidite 5'-O-DMT-2'-TBDMS-rA(N-Bz)-3'-CEDPA N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]purin-6-yl]benzamide 5'-DMT-2'-TBDMS-rA(N-Bz) Phosphoramidite N6-Benzoyl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite TIANFU-CHEM N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite 5'-Dimethoxytrityl-N-benzoyl-Adenosine, 2'-O-TBDMS-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimet... N-diisopropyl)phosphoramidite N-Benzoyl-5-O-(4 4-Dimethoxytrityl)-2-O-[(tert-butyl)dimethylsilyl]adenosine-3-(2-cyanoethyl-N 5'-DMT-2'-TBDMS-N6-Bz-rA phosphoramidite 2'-TBDMS-A CEP 5'-O-DMT-2'-O-TBDMS-N6-Benzoyl-Adenosine 3'-CE phosphoramidite 5'-O-DMT-2'-O-tert-Butyldimethylsilyl-N6-Benzoyl-adenosine 3'-CE phosphoramidite Adenosine,N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-,3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] (9CI) 8-Aza-7-deaza-A CEP 5'-O-DMT-2'-O-tert-Butyldimethylsiyl-N6-Benzoyl-adenosine 3'-CE phosphoramidite Bz-rA Phosphoramidite N6-Benzoyl-5'-O-DMT-2'-O-TBDMS adenosine 3'-CE phosphoramidite 2TBDMS-rA(BZ) Phosphoramidite N6-Bz-5'-O-DMT-2'-O-TBDMS-A-CE 2'-O-TBDMS-A(Bz) CE Phosphoramidite 5'-O-DMT-2'-O-TBDMS-N6-Benzoyl-Adenosine-3’-Cyanoethyl Phosphoramidite RNA N-Bz A Amidite DMT-2'-O-TBDMS-A(Bz)-CE DMTr-2'-O-TBDMS-rA(Bz)-3'-CE-Phosphoramidite 2’-OTBDMS-rA(Bz) Amidite 5'-ODMT-2'-OTBDMS-N-Bz Adenosine-3'-OCEPA DMT-2'-0-TBDMS-rA(BZ) DMT-2'O-TBDMS-rA(bz) Phosphoramidite 2'-O-TBDMS-A(Bz)-CE Phosphoramidite DMT-2'-O-TBDMS-A(Bz)-CE-Phosphoramidite 5'-O-DMT-2'-O-TBDMS-N6-Benzoyl-Adenosine 3'-CE phosphoramidite N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)adenosine 3'-O-(2-cyanoethyl N,N-diisopropylphosphoramidite) N-(9-[(2R,4R,5R)-5-[(bis(4-methoxyphenyl)(phenyl)methoxy)methyl]-4-{[(bis(propan-2-yl)amino)(2-cyanoethoxy)phosphanyl]oxy}-3-[(tert-butyldimethylsilyl)oxy]oxolan-2-yl]-9H-purin-6-yl)benzamide N6-Bz-2'-O-TBDMS-5'-O-DMT-A-3'-CE-Phosphoramidite 2'-TBDMS-rA(Bz)Phosphoramidite 5'-O-DMT-2'-O-tert-Butyldimethylsilyl-N6-Benzoyl-adenosine 3'-CE phosphoramidite 5'-O-DMT-2'-O-TBDMS-N6-Benzoyl-Adenosine-3’-Cyanoethyl Phosphoramidite 104992-55-4 C53H66N7O8PSi Pharmaceutical Amidite