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DMT-2'O-TBDMS-rA(bz) Phosphoramidite
- CAS No.
- 104992-55-4
- Chemical Name:
- DMT-2'O-TBDMS-rA(bz) Phosphoramidite
- Synonyms
- Bz-rA Phosphoramidite;2'-TBDMS-A CEP;N-Benzoyl-5-O-(4;RNA N-Bz A Amidite;8-Aza-7-deaza-A CEP;DMT-2'-0-TBDMS-rA(BZ);DMT-2'-O-TBDMS-A(Bz)-CE;2’-OTBDMS-rA(Bz) Amidite;N-diisopropyl)phosphoramidite;2TBDMS-rA(BZ) Phosphoramidite
- CBNumber:
- CB41871629
- Molecular Formula:
- C53H66N7O8PSi
- Molecular Weight:
- 988.19
- MOL File:
- 104992-55-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/27 9:38:02
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| WGK Germany | 3 |
| HS Code | 29349990 |
DMT-2'O-TBDMS-rA(bz) Phosphoramidite price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A211050 | DMT-2′O-TBDMS-rA(bz) Phosphoramidite configured for (?KTA? and OligoPilot?) | 104992-55-4 | 2G | ₹16367.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A211050 | DMT-2′O-TBDMS-rA(bz) Phosphoramidite configured for (?KTA? and OligoPilot?) | 104992-55-4 | 5G | ₹40182.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A211050 | DMT-2′O-TBDMS-rA(bz) Phosphoramidite configured for (?KTA? and OligoPilot?) | 104992-55-4 | 10G | ₹80321.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A211040 | DMT-2′O-TBDMS-rA(bz) Phosphoramidite configured for MerMade | 104992-55-4 | 0.5G | ₹9731.68 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A211040 | DMT-2′O-TBDMS-rA(bz) Phosphoramidite configured for MerMade | 104992-55-4 | 5G | ₹42693.8 | 2022-06-14 | Buy |
DMT-2'O-TBDMS-rA(bz) Phosphoramidite Chemical Properties,Uses,Production
Uses
N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite can be used as Organic synthesis intermediates and pharmaceutical intermediates are mainly used in laboratory research and development processes and chemical production processes.
Uses
DMT-2''O-TBDMS-rA(bz) Phosphoramidite (DMT-2'O-TBDMS-rA(bz) Phosphoramidite) is a 2''-O-Protected ribonucleoside phosphoramidite used as a key raw material for the automated solid-supported synthesis of oligonucleotide-based drugs. It is also used to synthesize 2''-O-guanidinopropyl-modified nucleoside phosphoramidites to incorporate into siRNAs targeting hepatitis B virus.
Synthesis
To a solution of 72 (12.0 g, 15.2 mmoi) in DIPEA (15 ml) and DCM (30 mL) is added DMAP (744 mg, 6.09 rnrnol) and 2cyanoethyl JV.Ndiisopropylchlorophosphoramidite (5.41 g, 22.9 rnmoi) at 25 ℃. After stirring for 2 hours, the mixture is purified directly by basic silica gel column chromatography (EAIPE 1/4 toi/1) to give DMT-2'O-TBDMS-rA(bz) Phosphoramidite as a white solid (13.0 g. 86% yield)
DMT-2'O-TBDMS-rA(bz) Phosphoramidite Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 190)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Innovassynth Technologies (I) Ltd. | +91-2192260100 +91-7208872197 | Maharashtra, India | 118 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6100 | 58 | Inquiry |
| A. B. Enterprises | +91-8048077585 | Mumbai, India | 1394 | 58 | Inquiry |
| Allbiosyn Biotechnology Co.,Ltd. | +8618666985712 | China | 295 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | China | 29730 | 60 | Inquiry |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-+86-371-66670886 | China | 19809 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21628 | 55 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29859 | 58 | Inquiry |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | China | 8497 | 58 | Inquiry |
| Yunbio Tech Co.,Ltd. | +86-010-60605551 +86-18046518538 | China | 321 | 58 | Inquiry |
104992-55-4(DMT-2'O-TBDMS-rA(bz) Phosphoramidite)Related Search:
Cyhalofop-butyl
Benzoyl peroxide
Dimethyldimethoxysilane
tert-Butyl acetate
tert-Butyldimethylsilyl chloride
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DMT-2′O-TBDMS-rA(bz) Phosphoramidite
2'-TBDMS -Bz-rA-CE-Phosphoramidite
5'-DMT-2'-O-TBDMS- N6-Benzoyl-Adenosine Phosphoramidite
(2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(tert-butyldimethylsilyloxy)tetrahydrofuran-3-yl 2-cyanoethyl diisopropylphosphoramidite
REF DUPL: 2'-TBDMS-rA(N-Bz)Phosphoramidite
N6-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine 3'-CE phosphoramidite
5'-O-(4,4'-DiMethoxy)-N6-benzoyl-2'-O-(t-butyl diMethylsilyl)adenosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoraMidite
5'-O-DMT-2'-O-TDMS-N6-Bz-Adenosine-3'-CED PhosphoraMidite
Adenosine, N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-O-[(1,1-diMethylethyl)diMethylsilyl]-, 3'-[2-cyanoethyl bis(1-Methylethyl)phosphoraMidite]
2’-TBDMS-rA(N-Bz) Phosphoramidite
5'-O-DMT-2'-TBDMS-rA(N-Bz)-3'-CEDPA
N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]purin-6-yl]benzamide
5'-DMT-2'-TBDMS-rA(N-Bz) Phosphoramidite
N6-Benzoyl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
TIANFU-CHEM N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
5'-Dimethoxytrityl-N-benzoyl-Adenosine, 2'-O-TBDMS-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimet...
N-diisopropyl)phosphoramidite
N-Benzoyl-5-O-(4
4-Dimethoxytrityl)-2-O-[(tert-butyl)dimethylsilyl]adenosine-3-(2-cyanoethyl-N
5'-DMT-2'-TBDMS-N6-Bz-rA phosphoramidite
2'-TBDMS-A CEP
5'-O-DMT-2'-O-TBDMS-N6-Benzoyl-Adenosine 3'-CE phosphoramidite
5'-O-DMT-2'-O-tert-Butyldimethylsilyl-N6-Benzoyl-adenosine 3'-CE phosphoramidite
Adenosine,N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-,3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] (9CI)
8-Aza-7-deaza-A CEP
5'-O-DMT-2'-O-tert-Butyldimethylsiyl-N6-Benzoyl-adenosine 3'-CE phosphoramidite
Bz-rA Phosphoramidite
N6-Benzoyl-5'-O-DMT-2'-O-TBDMS adenosine 3'-CE phosphoramidite
2TBDMS-rA(BZ) Phosphoramidite
N6-Bz-5'-O-DMT-2'-O-TBDMS-A-CE
2'-O-TBDMS-A(Bz) CE Phosphoramidite
5'-O-DMT-2'-O-TBDMS-N6-Benzoyl-Adenosine-3’-Cyanoethyl Phosphoramidite
RNA N-Bz A Amidite
DMT-2'-O-TBDMS-A(Bz)-CE
DMTr-2'-O-TBDMS-rA(Bz)-3'-CE-Phosphoramidite
2’-OTBDMS-rA(Bz) Amidite
5'-ODMT-2'-OTBDMS-N-Bz Adenosine-3'-OCEPA
DMT-2'-0-TBDMS-rA(BZ)
DMT-2'O-TBDMS-rA(bz) Phosphoramidite
2'-O-TBDMS-A(Bz)-CE Phosphoramidite
DMT-2'-O-TBDMS-A(Bz)-CE-Phosphoramidite
N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)adenosine 3'-O-(2-cyanoethyl N,N-diisopropylphosphoramidite)
N-(9-[(2R,4R,5R)-5-[(bis(4-methoxyphenyl)(phenyl)methoxy)methyl]-4-{[(bis(propan-2-yl)amino)(2-cyanoethoxy)phosphanyl]oxy}-3-[(tert-butyldimethylsilyl)oxy]oxolan-2-yl]-9H-purin-6-yl)benzamide
N6-Bz-2'-O-TBDMS-5'-O-DMT-A-3'-CE-Phosphoramidite
2'-TBDMS-rA(Bz)Phosphoramidite
Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite
5'-O-DMT-2'-O-tert-Butyldimethylsiyl-N6-Benzoyl-adenosine 3'-CE phosphoramidite
104992-55-4
C53H66N7O8PSi
Pharmaceutical
Amidite