RICININE
- CAS No.
- 524-40-3
- Chemical Name:
- RICININE
- Synonyms
- ricinin;Ricidine;RICININE;Ritsinin;recinine;NSC 642604;NSC 409913;Ricinine (6CI);Ricinine solution;2-keto-4-methoxy-1-methyl-nicotinonitrile
- CBNumber:
- CB2202950
- Molecular Formula:
- C8H8N2O2
- Molecular Weight:
- 164.16
- MOL File:
- 524-40-3.mol
- Modify Date:
- 2023/9/4 15:51:00
| Melting point | 201.5° |
|---|---|
| Boiling point | 291.62°C (rough estimate) |
| Density | 1.2739 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| Flash point | 2℃ |
| storage temp. | -20°C |
| solubility | DMSO: slightly soluble,Methanol: slightly soluble |
| form | A solid |
| pka | -4.93±0.62(Predicted) |
| Water Solubility | 2.7g/L(10 ºC) |
| CAS DataBase Reference | 524-40-3 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P301+P310 | |||||||||
| Hazard Codes | T,Xn,F | |||||||||
| Risk Statements | 25-36-20/21/22-11 | |||||||||
| Safety Statements | 45-36/37-16 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | QT3100000 | |||||||||
| NFPA 704 |
|
RICININE Chemical Properties,Uses,Production
Description
First isolated by Tuson from the seeds of Ricinus communis (castor-oil seed), the alkaloid was subsequently examined by Soave, Schultze and Evans. The base crystallizes from H20 in colourless prisms or leaflets and sublimes at 170-lS0°C/ 20 mm. It is soluble in hot H20 or CHCI3, only sparingly so in EtOH and insoluble in petroleum ether, is neutral in reaction, optically inactive and forms no normal salts although the mercurichloride, m.p. 204°C has been prepared. The alkaloid reduces KMn04 and may be hydrolyzed by alkalies to MeOH and ricininic acid which forms brilliant, slender needles, m.p. 296-8°C (dec.). The structure of ricinine has been confirmed by synthesis from 4-chloroquinoline. Other syntheses have also been achieved. The base is not particularly toxic and the poisonous character of castor-oil seeds has been shown to be due to a more complex substance, ricin, the toxicity of which may be destroyed by heating.
Chemical Properties
White Solid
Uses
Ricinine is an alkaloid extract from the seeds of the castor-oil plant (Ricinus communalis). Ricinine is a central nervous system stimulant that could potentially be a cognition-enhancing agent used for the treatment of human amnesias. Ricinine also has bactericidal effects on three pests and heptaprotective activity.
Hazard
Toxic by ingestion.
Safety Profile
A poison by ingestion and subcutaneous route. When heated to decomposition it emits toxic vapors of NOx.
References
Tuson.,J. Chern. Soc., 17,195 (1864)
Soave., Chern. Soc. Abstr., i, 386 (1896)
Schultze., ibid, i, 42 (1898)
Evans., J. Arner. Chern. Soc., 22, 39 (1900)
Maqueen, Philippe., Cornpt. rend., 138, 506 (1904)
Maqueen, Philippe., ibid, 139, 840 (1904)
Winterstein, Keller, Weinhagen., Arch. Pharrn., 255,513 (1917)
Bottcher., Ber., 51,673 (1918)
Spath, Tschelnitz., Monatsh., 42,251 (1921)
Spath, Koller., Ber., 56, 880, 2454 (1923)
Spath, Koller., ibid, 58,2124 (1925)
Schroeter et ai., ibid, 65, 432 (1932)
Reitmann., Chern. Abstr., 29,4359 (1935)
RICININE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | China | 3424 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 | China | 2417 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| JiangSu Star Science Co.,Ltd | 400-605-7200 17312445705 | China | 3764 | 58 | Inquiry |
| Cayman Chemical Company | (800) 364-9897 | United States | 6618 | 81 | Inquiry |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | China | 8740 | 58 | Inquiry |
| Shanghai Moqi Biological Technology Co., LTD | 021-38218169 13341702378 | China | 9117 | 58 | Inquiry |
| Krain Pharmaceutical Technology CO.,Ltd | 18252089365 | China | 2632 | 58 | Inquiry |
| Hebei Zhentian food additives Co., LTD | 0319-5925599 13373390591 | China | 10682 | 58 | Inquiry |