Nerolidol
- CAS No.
- 7212-44-4
- Chemical Name:
- Nerolidol
- Synonyms
- TRANS-NEROLIDOL;(E)-3,7,11-TRIMETHYL-1,6,10-DODECATRIEN-3-OL;nerolido;HuMbertiol;3,7,11-TRIMETHYL-1,6,10-DODECATRIEN-3-OL;1,6,10-dodecatrien-3-ol,3,7,11-trimethyl-;FCI-119b;FEMA 2772;Nerolidol;NerolidoI
- CBNumber:
- CB2206877
- Molecular Formula:
- C15H26O
- Molecular Weight:
- 222.37
- MOL File:
- 7212-44-4.mol
- Modify Date:
- 2024/7/22 17:51:23
| Melting point | -75 °C |
|---|---|
| Boiling point | 114 °C/1 mmHg (lit.) |
| Density | 0.875 g/mL at 25 °C (lit.) |
| vapor pressure | <1 hPa (20 °C) |
| FEMA | 2772 | NEROLIDOL (ISOMER UNSPECIFIED) |
| refractive index |
n |
| Flash point | 230 °F |
| storage temp. | Store below +30°C. |
| solubility | 0.014g/l, Very slightly soluble in water, soluble in alcohol and oils. |
| pka | 14.44±0.29(Predicted) |
| form | Liquid |
| color | Clear slightly yellow |
| Specific Gravity | 0.88 |
| Odor | at 100.00 %. floral green waxy citrus woody |
| Odor Type | floral |
| explosive limit | 0.7-4.5%(V) |
| Water Solubility | immiscible |
| Merck | 14,6476 |
| JECFA Number | 1646 |
| BRN | 1724135 |
| LogP | 4.5 at 24℃ |
| CAS DataBase Reference | 7212-44-4(CAS DataBase Reference) |
| NIST Chemistry Reference | 1,6,10-Dodecatrien-3-ol, 3,7,11-trimethyl-(7212-44-4) |
| EPA Substance Registry System | Nerolidol (7212-44-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H317-H319-H410 | |||||||||
| Precautionary statements | P261-P264-P273-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,N | |||||||||
| Risk Statements | 36/37/38-50/53 | |||||||||
| Safety Statements | 26-36-61-60 | |||||||||
| RIDADR | UN 3082 9 / PGIII | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | JR4977000 | |||||||||
| F | 10-23 | |||||||||
| Autoignition Temperature | 230 °C | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29052290 | |||||||||
| Toxicity | LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rabbit > 5000 mg/kg | |||||||||
| NFPA 704 |
|
Nerolidol price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | W277207 | Nerolidol mixture of cis and trans, ≥97%, stabilized, FG | 7212-44-4 | 1SAMPLE-K | ₹5141.88 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W277207 | Nerolidol mixture of cis and trans, ≥97%, stabilized, FG | 7212-44-4 | 1KG | ₹11582.75 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W277207 | Nerolidol mixture of cis and trans, ≥97%, stabilized, FG | 7212-44-4 | 4KG | ₹37021.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W277207 | Nerolidol mixture of cis and trans, ≥97%, stabilized, FG | 7212-44-4 | 9KG | ₹92965.1 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | H59605 | Nerolidol 98%, Mixture of cis and trans | 7212-44-4 | 25G | ₹2305.73 | 2022-06-14 | Buy |
Nerolidol Chemical Properties,Uses,Production
Description
Nerolidol has a faint, floral odor similar to rose and apple. It is an unusually sweet, fresh, tenacious odor. The natural product can be dextro- or levo-rotatory, whereas the synthetic product is optically inactive; the double bond at positions 6-7 accounts for the cis- and trans-forms.
Chemical Properties
Nerolidol is the sesquiterpene
analog of linalool. Because of the double bond at the 6-position, it exists as (6Z)- and (6E)- isomers, each forming an enantiomeric pair,
since the carbon atom in the 3-position is asymmetric.
Nerolidol is a component of many essential oils. (3S,6E)-(+)-nerolidol occurs in cabreuva oil.
Synthetic nerolidol consists of a mixture of racemic (6Z)- and (6E)-nerolidol
and is a colorless liquid with a long-lasting, mild floral odor.
Industrial synthesis of nerolidol starts with linalool, which is converted into
geranylacetone by using diketene, ethyl acetoacetate, or isopropenyl methyl
ether, analogously to the synthesis of 6-methyl-5-hepten-2-one from 2-methyl-
3-buten-2-ol. Addition of acetylene and partial hydrogenation of the resultant
dehydronerolidol produces a mixture of (6Z)- and (6E)-nerolidol racemates.Nerolidol is used as a base note in many delicate floral odor complexes. It is also
an intermediate in the production of vitamins E and K1.
Occurrence
Reported found in over 25 natural sources, including the essential oils of neroli, ylang-ylang, Peru balsam; in currant aroma; also reported in Dalbergia sissoo (60%, dl-), vervain, the distillation water of petitgrain bigarade, Helicrysum italicum, Myrocarpus frondosus and Myrocarpus fastigiatus (80%, d-), Tolu balsam, Acacia farnesiana, orange flower water, Paraguay petitgrain, jasmine, Melaleuca smithii and Melaleuca viridiflora. Also reported found in citrus peel oils and juices, guava, strawberry, peppermint and spearmint oil, pepper, milk powder, hop oil, beer, cognac, white wine, green tea, beans, mushroom, cardamom, rice, dill, corn oil, basil, wort, myrtle leaf, maté and mastic gum oil.
Uses
Nerolidol is one of the main component in the essential oils from fresh aerial parts of Thymus ciliatus (Lamiaceae). Also, it is a terpene that displays high potency on the contractility of cardiac muscle in guinea pig left atrium. A potential and effective treatment for malaria.
Preparation
1) From Geranylacetone plus Acetylene, followed by reduction of the acetylenic linkage (HotTmann-laRoche process).
2) by isolation from Cabreuva oil or other
essential oils.
General Description
Nerolidol is a naturally occurring sesquiterpene found in the essential oils.
Nerolidol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Anupam Industries | 91-22-43555100 | Maharashtra, India | 99 | 58 | Inquiry |
| P.P. Sheth Aromas Pvt., Ltd. | 91-22-27780900 | Maharashtra, India | 35 | 58 | Inquiry |
| Karnataka Aromas | 08068970631Ext 815 | Karnataka, India | 104 | 58 | Inquiry |
| Vijay Trading Company | 91-22-24132120 | Maharashtra, India | 109 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | China | 12456 | 58 | Inquiry |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | China | 3002 | 58 | Inquiry |
| JINING XINHE CHEMICAL CO., LTD | +8615318402391 | China | 807 | 58 | Inquiry |
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