PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]-
![PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]- Structure](CAS/GIF/1638-41-1.gif)
- CAS No.
- 1638-41-1
- Chemical Name:
- PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]-
- Synonyms
- p38 MAPK Inhibitor IV;p38 MAP Kinase Inhibitor IV;p38 MAP Kinase Inhibitor IV (B10);2,2'-Sulfonylbis(3,4,6-trichlorophenol);PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]-;p38 MAP Kinase Inhibitor IV,p-38 MAP Kinase Inhibitor IV;p38 MAP Kinase Inhibitor IV - CAS 1638-41-1 - Calbiochem;Phenol, 3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxyphenyl)sulfonyl]-
- CBNumber:
- CB22446185
- Molecular Formula:
- C12H4Cl6O4S
- Molecular Weight:
- 456.94
- MOL File:
- 1638-41-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/7/14 17:34:47
| Melting point | 244-245 °C(Solv: ethyl acetate (141-78-6)) |
|---|---|
| Boiling point | 590.0±50.0 °C(Predicted) |
| Density | 1.854±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble5mg/mL, clear (warmed) |
| form | powder |
| pka | 2.43±0.50(Predicted) |
| color | white to beige |
PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]- price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0543 | p38 MAP Kinase Inhibitor IV ≥98% (HPLC) | 1638-41-1 | 5MG | ₹12297.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 506153 | p38 MAP Kinase Inhibitor IV - CAS 1638-41-1 - Calbiochem The p38 MAP Kinase Inhibitor IV, also referenced under CAS 1638-41-1, controls the biological activity of p38 MAP Kinase. This small molecule/inhibito | 1638-41-1 | 10MG | ₹19050 | 2022-06-14 | Buy |
PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]- Chemical Properties,Uses,Production
Uses
p38 MAP Kinase Inhibitor IV is an ATP-competitive p38α/β MAPK inhibitor.
General Description
A cell-permeable symmetrical sulfone compound that acts as a potent and ATP-competitive inhibitor of p38α/β MAPK (IC50 = 130 and 550 nM, respectively), while exihibiting much reduced activity (≤23% inhibition at 1 μM) against p38γ/δ, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203850 (Cat. Nos. 559389, 559395, and 559398) in inhibiting LPS-induced IL-1β release from hPBMC (100% vs. 50% inhibition with 100 μM respective inhibitor).
Biochem/physiol Actions
p38 MAP Kinase Inhibitor IV is an ATP-competitive inhibitor of p38α/β MAPK with IC50 values of 130 nM for p38α and 550 nM for p38β. It is much less active with ≤23% inhibition at 1 μM against p38γ/σ, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203580 in inhibiting LPS-induced IL-1β release from hPBMC (100% vs. 50% inhibition with 100 μM inhibitor). A recent study showed that p38 MAP Kinase Inhibitor IV could consistently and significantly enhance reprogramming and iPS cell generation from somatic cells.
PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]- Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30253 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
| Amadis Chemical Company Limited | 571-89925085 | China | 131980 | 58 | Inquiry |
| Beijing Bi Orange Blue Biotechnology Co., Ltd. | 15510022373 | CHINA | 6827 | 58 | Inquiry |
| Beijing Zhijie Fangyuan Technology Co., Ltd. | 010-82897201 15810200961 | CHINA | 6984 | 58 | Inquiry |
| Guangzhou Weijia Technology Co., Ltd. | 020-84224925 18300190102 | CHINA | 6748 | 58 | Inquiry |
| Beijing Baiao Innovation Technology Co., Ltd. | 010-5718533 13366620421 | CHINA | 6005 | 58 | Inquiry |
| Beijing Xiangsheng Xingye Technology Co., Ltd. | 0136-81184382 13681184382 | CHINA | 5130 | 58 | Inquiry |
| Beijing Shengke Boyuan Biotechnology Co., Ltd. | 010-62968438 | CHINA | 6011 | 58 | Inquiry |
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