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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Neuronal Signaling >Adrenergic Receptor agonists >Mirabegron

Mirabegron

Mirabegron Structure
CAS No.
223673-61-8
Chemical Name:
Mirabegron
Synonyms
Mirabelon;YM 178;CS-732;Betmiga;Mirabello;Mirabegron;MIRABEQRON;Mira veron;Mirabregon;Mirabellon
CBNumber:
CB22493967
Molecular Formula:
C21H24N4O2S
Molecular Weight:
396.51
MOL File:
223673-61-8.mol
MSDS File:
SDS
Modify Date:
2024/4/12 23:00:59
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Mirabegron Properties

Melting point 138-140°C
Boiling point 690.0±55.0 °C(Predicted)
Density 1.313
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility Chloroform (Slightly, Heated), Methanol (Slightly)
form Solid
pka 13.51±0.70(Predicted)
color White to Pale Yellow
InChIKey PBAPPPCECJKMCM-IBGZPJMESA-N
SMILES S1C=C(CC(NC2=CC=C(CCNC[C@H](O)C3=CC=CC=C3)C=C2)=O)N=C1N
CAS DataBase Reference 223673-61-8

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08
Signal word  Warning
Hazard statements  H361d
Precautionary statements  P201-P202-P280-P308+P313-P405-P501
NFPA 704
0
2 0

Mirabegron price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML2480 Mirabegron ≥98% (HPLC) 223673-61-8 5MG ₹10673.45 2022-06-14 Buy
Sigma-Aldrich(India) SML2480 Mirabegron ≥98% (HPLC) 223673-61-8 25MG ₹42975.25 2022-06-14 Buy
Product number Packaging Price Buy
SML2480 5MG ₹10673.45 Buy
SML2480 25MG ₹42975.25 Buy

Mirabegron Chemical Properties,Uses,Production

Description

Betanis (Mirabegron) was approved in July 2011 by the Japanese Ministry of Health, Labour, and Welfare for the treatment of urgency, urinary frequency, and urinary urge urinary incontinence associated with overactive bladder (OAB). Mirabegron is synthesized by coupling 4-nitrophenethyl amine to (R)-2-hydroxy-2-phenylacetic acid. The resulting amide is reduced to an amine. The nitro group is then reduced and the resulting aniline is coupled to 2-(2-aminothiazol-4-yl) acetic acid to give mirabegron. Mirabegron has an EC50 of 22 nM (intrinsic activity=0.8) for β3-AR with no detectable activity for β1- andβ2-AR (EC50>10,000 nM). In an anesthetized rat rhythmic bladder contraction model in which bladder contractions are induced by saline, mirabegron at 3 mg/kg iv decreased the frequency of rhythmic bladder contraction without suppressing contraction amplitude. These data suggest that the activation of β3-AR increases bladder capacity without influencing the frequency of bladder contraction.

Chemical Properties

White to Off-White Solid

Uses

Potent bladder relaxant and reagent for diabetes remedy.;Labeled Mirabegron, intended for use as an internal standard for the quantification of Mirabegron by GC- or LC-mass spectrometry.

Definition

ChEBI: A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2-amino-1,3-thiazol-4-ylacetic acid with the anilino group of (1R)-2-{[2-(4-aminophenyl)ethyl]amino}-1-phenylethanol. Used for the treatment of overactive ladder syndrome.

Clinical Use

Mirabegron is an orally active β3-adrenoceptor agonist currently in development by Astellas Pharma for the treatment of overactive bladder (OAB). The drug is a nanomolar EC50 antagonist against human β3-AR biochemical assays with good selectivity over b1- and β2-ARs. Mirabegron demonstrates a novel mechanism by targeting the β3-AR for bladder relaxation to help manage OAB symptoms such as increased urinary urgency and frequency and urgency incontinence. However, mirabegron is a cytochrome P450 2D6 inhibitor, and it raises a concern for drug–drug interaction with concomitant administration of other cytochrome P450 2D6 substrates.

Mirabegron Preparation Products And Raw materials

Raw materials

BenzeneMethanol, a-[[[2-(4-aMinophenyl)ethyl]aMino]Methyl]-, (aR)- (alphaR)-alpha-[[[2-(4-Aminophenyl)ethyl]amino]methyl]benzenemethanol hydrochloride 2-Aminothiazole-4-acetic acid

Preparation Products

Mirabegron Suppliers

Global( 489)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Jigs Chemical ltd +919099003427 Gujarat, India 239 58 Inquiry
HEMA PHARMACEUTICALS PVT LTD +91-9537936912 +91-9537936912 Gujarat, India 48 58 Inquiry
AVD pharmaceuticals Pvt Ltd +919860835260 Pune, India 102 58 Inquiry
Indian Drugs And Chemicals +undefined-9849918777 +undefined-9848046097 Hyderabad, India 4 58 Inquiry
Dr. Reddy's Laboratories Ltd +91-4049002900 +91-4049002900 Hyderabad, India 165 58 Inquiry
Global Pharma +91-9819994077 +91-9819994077 Maharashtra, India 34 58 Inquiry
SNA HEALTHCARE PVT LTD +91-8652842416 +91-8652842416 Mumbai, India 88 58 Inquiry
GLP Pharma Standards +91 9866074638 Hyderabad, India 1644 58 Inquiry
Lewens Labs +917043057100 Gujarat, India 30 58 Inquiry
Metrochem API Private Limited +91-4069069999 +91-4069069999 Telangana, India 78 58 Inquiry
Supplier Advantage
Jigs Chemical ltd 58
HEMA PHARMACEUTICALS PVT LTD 58
AVD pharmaceuticals Pvt Ltd 58
Indian Drugs And Chemicals 58
Dr. Reddy's Laboratories Ltd 58
Global Pharma 58
SNA HEALTHCARE PVT LTD 58
GLP Pharma Standards 58
Lewens Labs 58
Metrochem API Private Limited 58

Mirabegron Spectrum

Mirabegron(223673-61-8)1HNMR

223673-61-8(Mirabegron)Related Search:

(R)-2-(2-aminothiazol-4-yl)-N-(4-(2-((4-(2-((2-hydroxy-2-phenylethyl)amino)ethyl)phenyl)amino)-2-oxoethyl)thiazol-2-yl)acetamide Mirabegron Deshydroxy Mirabegron Impurity 4 (alphaR)-alpha-Hydroxy-N-[2-(4-nitrophenyl)ethyl]benzeneacetamide (alphaR)-alpha-[[[2-(4-Aminophenyl)ethyl]amino]methyl]benzenemethanol hydrochloride
(alphaR)-alpha-[[[2-(4-Nitrophenyl)ethyl]amino]methyl]benzenemethanol BenzeneMethanol, -[[[2-(4-nitrophenyl)ethyl]aMino]Methyl]-, (R)- Mirabegron Impurity Mirabegron Impurity Bestatin
Tafluprost VILAZODONE Rivaroxaban MLN9708 ISRIB (trans-isoMer)
Albuterol sulfate Temsirolimus Elesclomol
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2-AMino-N-[4-[2-[[(2R)-2-hydroxy-2-phenyl-ethyl]aMino]-ethyl]phenyl]-4-thiazoleacetaMide 2-(2-aMino-1,3-thiazol-4-yl)-N-(4-{2-[(2-hydroxy-2-phenylethyl)aMino]ethyl}phenyl)acetaMide (2R)-2-(2-AMinothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)aMino]ethyl]acetic Acid Anilide 4-Thiazoleacetamide, 2-amino-N-(4-(2-(((2R)-2-hydroxy-2-phenylethyl)amino)ethyl)phenyl)- Mirabegron N-(4-(2-(2-hydroxy-2-phenylethylamino)ethyl)phenyl)-2-(2-aminothiazol-4-yl)acetamide YM 178 Mirabegron(YM 178) MIRABEQRON Merariveron impurity B 2-(2-Amino-1,3-thiazol-4-yl)-N-[4-(2-{[(2R)-2-hydroxy2-phenylethyl]amino}ethyl)phenyl]acetamide Mirabegron, >=99% Mira veron (R)-2-(2-aminothiazol-4-yl)-4'-{2-[(2-hydroxy-2-phenylethyl)amino]ethyl}acetanilide Mirabegron Intermediates Mirabregon Mirabello CS-732 (R)-2-(2-aminothiazol-4-yl)-N-(4-(2-(2-hydroxy-2-phenylethylamino)ethyl)phenyl)acetamide hot selling Mirabegron Mirabegron USP/EP/BP Mirabegron (API) (R)-N-(4-(2-(2-aminothiazol-4-yl)acetamido)phenethyl)-2-hydroxy-2-phenylacetamide Mirabegron-d8 (R)-N-(4-(2-((2-hydroxy-2-phenylethyl)amino)ethyl)phenyl)-2-(2-imino-2,3-dihydrothiazol-4-yl)acetamide MirabegronQ: What is Mirabegron Q: What is the CAS Number of Mirabegron Q: What is the storage condition of Mirabegron Q: What are the applications of Mirabegron Mirabelon Mirabellon Betmiga Benzenamine,N,N,3,11-tetramethyl- 1-Pyrrolidinepropanoicacid,2,6-dioxo- Merabegron Mirabegron (Alpha and Amorphous) 223673-61-8 23673-61-8 Amines Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds 223673-61-8