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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Protein tyrosine kinase /JAK / STAT >JAK inhibitors >JAK3 Inhibitor

JAK3 Inhibitor

JAK3 Inhibitor Structure
CAS No.
211555-04-3
Chemical Name:
JAK3 Inhibitor
Synonyms
CS-1516;whi-p154cas;JAK3 Inhibitor;JAK3 Inhibitor II WHI-P154;JAK3 Inhibitor II - CAS 211555-04-3 - Calbiochem;2-Bromo-4-((6,7-dimethoxyquinazolin-4-yl)amino)phenol;2-Bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol;Phenol, 2-bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]-;4-(3'-Bromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline WHI-P 154;Janus kinase,ErbB-1,Apoptosis,inhibit,JAK,Epidermal growth factor receptor,WHI-P154,HER1,WHIP154,Inhibitor,WHI-P-154,WHI P154,EGFR
CBNumber:
CB22502881
Molecular Formula:
C16H14BrN3O3
Molecular Weight:
376.2
MOL File:
211555-04-3.mol
MSDS File:
SDS
Modify Date:
2023/6/30 15:45:59
Request For Quotation

JAK3 Inhibitor Properties

Melting point 230 °C
Boiling point 470.3±45.0 °C(Predicted)
Density 1.576±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO: soluble1mg/mL, clear (warmed)
pka 8.57±0.31(Predicted)
form powder
color white to brown
InChIKey CBIAKDAYHRWZCU-UHFFFAOYSA-N
CAS DataBase Reference 211555-04-3

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301-H315-H319-H335
Precautionary statements  P261-P301+P310-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  26
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
HS Code  2933.59.8000
NFPA 704
0
2 0

JAK3 Inhibitor price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 420104 JAK3 Inhibitor II - CAS 211555-04-3 - Calbiochem The JAK3 Inhibitor II, also referenced under CAS 211555-04-3, controls the biological activity of JAK3. This small molecule/inhibitor is primarily use 211555-04-3 5MG ₹28660 2022-06-14 Buy
TCI Chemicals (India) W0013 WHI-P154 211555-04-3 10MG ₹6200 2022-05-26 Buy
TCI Chemicals (India) W0013 WHI-P154 211555-04-3 50MG ₹17200 2022-05-26 Buy
Product number Packaging Price Buy
420104 5MG ₹28660 Buy
W0013 10MG ₹6200 Buy
W0013 50MG ₹17200 Buy

JAK3 Inhibitor Chemical Properties,Uses,Production

Description

WHI-P154 is a quinazoline derivative that exhibits immunosuppressive effects by selectively inhibiting JAK3 (IC50 = 1.8 μM versus IC50s > 10 μM for JAK1 and JAK2). It has been reported to inhibit additional kinases including EGFR (IC50 = 4 nM) and VEGFR as well as the non-receptor tyrosine kinases, Abl, Lck, and Src. WHI-P154 is cytotoxic to human glioblastoma cells (IC50 = 813 nM) and has been used to induce the differentiation of neuronal precursor cells.

Uses

WHI-P154 is a potent JAK3 inhibitor with IC50 of 1.8 μM and also inhibits EGFR with IC50 of 4 nM.

Biochem/physiol Actions

WHI-P154 is a specific inhibitor of JAK3 (IC50 = 1.8 μM) with no inhibitory activity against JAK1 or JAK2. WHI-P154 enhances myogenic differentiation of C2C12 mouse myoblast cells, and induces differentiation of neural progenitor cells. The compound WHI-P154 dose dependently inhibits expression of iNOS and NO production in LPS-challenged macrophages.

JAK3 Inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

JAK3 Inhibitor Suppliers

Global( 119)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Nanjing Doge Biomedical Technology Co., Ltd +86-25-58227606 +86-15305155328 China 4128 58 Inquiry
Coresyn Pharmatech Co., Ltd. +86-571-86626709 +86-18157142896 China 9991 58 Inquiry
Supplier Advantage
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
TCI Chemicals (India) Pvt. Ltd. 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
TargetMol Chemicals Inc. 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
Nanjing Doge Biomedical Technology Co., Ltd 58
Coresyn Pharmatech Co., Ltd. 58

JAK3 Inhibitor Spectrum

JAK3 Inhibitor(211555-04-3)1HNMR

211555-04-3(JAK3 Inhibitor)Related Search:

JAK3 INHIBITOR I 4-(3'-HYDROXYPHENYL)AMINO-6,7-DIMETHOXYQUINAZOLINE, HCL 2-Bromopropane 1-Bromo-3-methylbutane 2-Methylsulfonyl-4,6-dimethoxypyrimidine
WHI-P97 4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- Tofacitinib citrate Stattic
(+)-JQ1 ABT-199 ABT 737 Entinostat
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JAK3 Inhibitor 2-Bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol Phenol, 2-bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]- 4-(3'-Bromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline WHI-P 154 2-Bromo-4-((6,7-dimethoxyquinazolin-4-yl)amino)phenol JAK3 Inhibitor II - CAS 211555-04-3 - Calbiochem CS-1516 whi-p154cas JAK3 Inhibitor II WHI-P154 Janus kinase,ErbB-1,Apoptosis,inhibit,JAK,Epidermal growth factor receptor,WHI-P154,HER1,WHIP154,Inhibitor,WHI-P-154,WHI P154,EGFR 211555-04-3 Inhibitors Inhibitor JAK/STAT JAK STAT